Publications by authors named "Yasmina Abukhadra"
Background And Objectives: This study aimed to evaluate and predict the effects of interictal epileptiform discharges (IEDs) on driving ability using simple reaction tests and a driving simulator.
Methods: Patients with various epilepsies were evaluated with simultaneous EEGs during their response to visual stimuli in a single-flash test, a car-driving video game, and a realistic driving simulator. Reaction times (RTs) and missed reactions or crashes (miss/crash) during normal EEG and IEDs were measured.
Conditional gene regulation in Drosophila through binary expression systems like the LexA-LexAop system provides a superb tool for investigating gene and tissue function. To increase the availability of defined LexA enhancer trap insertions, we present molecular, genetic, and tissue expression studies of 301 novel Stan-X LexA enhancer traps derived from mobilization of the index SX4 line. This includes insertions into distinct loci on the X, II, and III chromosomes that were not previously associated with enhancer traps or targeted LexA constructs, an insertion into ptc, and seventeen insertions into natural transposons.
View Article and Find Full Text PDFA machine-learning approach for predicting impaired consciousness in absence epilepsy.
Ann Clin Transl Neurol
October 2022
Article Synopsis
- Researchers investigated behavior during spike-wave discharges (SWDs) in absence epilepsy, focusing on the difficulty of assessing behavioral impairment without specialized tests.
- They developed a machine-learning method using EEG data to classify SWDs as either behaviorally spared or impaired, achieving high predictive accuracy with their models.
- The findings suggest that this approach could eventually help with predicting safety and treatment adjustments related to absence seizures, pending further validation with larger samples.
Article Synopsis
- Immunosuppression in glioblastoma (GBM) hinders effective immunotherapy, primarily due to the role of GBM-derived immunosuppressive monocytes and the PD-L1 checkpoint molecule expressed by GBM cells and extracellular vesicles (EVs).
- Research involved conditioning normal monocytes with GBM EVs to observe the formation of immunosuppressive monocytes and their impact on T-cell proliferation, using various methods to manipulate PD-L1 expression.
- Results showed that while GBM EVs do not directly inhibit T-cell activation, they do promote immunosuppressive monocyte populations that, in turn, suppress T-cell proliferation, highlighting the complexity of signaling mechanisms involved in this immunosuppression process.