Towards Bacterial Resistance via the Membrane Strategy: Enzymatic, Biophysical and Biomimetic Studies of the Lipid cis-trans Isomerase of Pseudomonas aeruginosa.

The lipid cis-trans isomerase (Cti) is a periplasmic heme-c enzyme found in several bacteria including Pseudomonas aeruginosa, a pathogen known for causing nosocomial infections. This metalloenzyme catalyzes the cis-trans isomerization of unsaturated fatty acids in order to rapidly modulate membrane fluidity in response to stresses that impede bacterial growth. As a consequence, breakthrough in the elucidation of the mechanism of this metalloenzyme might lead to new strategies to combat bacterial antibiotic resistance.

Translation, Cross-Cultural Adaptation and Validation of the Lymphedema Quality of Life Questionnaire (LYMQOL) in German-Speaking Patients with Upper Limb Lymphedema.

The LYMQOL is the most frequently translated, validated, objective tool for assessing Health-Related Quality of Life (HRQoL) in individuals with upper limb lymphedema (ULL). There have been adaptations and validations in a number of different countries. While a German version of LYMQOL Leg for lower limb lymphedema is available, a validated translation of LYMQOL Arm to German is lacking.

[Appearance, recurrence and prognosis of immunological graft rejection after penetrating keratoplasty].

Objective: The aim of this study was to examine the patterns of immunological graft rejection reactions (IAR) after penetrating keratoplasty (KPL) and to assess the prognosis for preservation of transparency of the corneal graft.

Patients And Methods: In the period from 2006 to 2015 a total of 190 IAR, which occurred in 120 eyes of 119 patients, were retrospectively analyzed. The underlying disease, number of previous KPL and IAR and measures of best corrected visual acuity (BCVA, logMAR) and pachymetry at the time points T1 = postoperatively, T2 = acute IAR, T3 = follow-up at 6 weeks and T4 = follow-up at 3-12 months were recorded.