Publications by authors named "Yasmin M M Mohammed"
Article Synopsis
- Platelet function varies widely among individuals, and current tests typically measure only the end-point activation levels without considering how quickly platelets activate, which might overlook important details about their reactivity.
- A new real-time flow cytometry method was developed to assess the speed of platelet activation, identifying distinct rates of response to different activating agents that do not necessarily relate to maximum activation levels.
- Findings show that faster platelet responses correlate with larger and denser blood clots in arterial conditions, suggesting that the activation rate should be considered in future antiplatelet therapies to enhance effectiveness while minimizing bleeding risk.
Platelets react rapidly to vascular injury and undergo activation in response to a range of stimuli to limit blood loss. Many platelet function tests measure endpoint responses after a defined time period and not the rate of platelet activation. However, the rate at which platelets convert extracellular stimuli into a functional response is an essential factor in determining how efficiently they can respond to injury, bind to a forming thrombus, and signal to recruit other platelets.
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