Publications by authors named "Yasmim de Oliveira Dalsenter"
Pharmacol Biochem Behav
November 2020
Article Synopsis
- AZD6765 (lanicemine) is a non-competitive NMDA antagonist that shows quick antidepressant effects in mice without causing psychotic symptoms, though its exact mechanism is still unclear.
- The study revealed that the antidepressant-like effects of AZD6765 are linked to the activation of specific signaling pathways (PI3K/Akt/mTOR/GSK3β) and can be enhanced when combined with certain GSK-3β inhibitors.
- Administration of AZD6765 also reduced depression-like behavior in other tests, highlighting its potential as a rapid antidepressant similar to ketamine, while involving the activation of mTOR signaling pathways.
