Publications by authors named "Yasmeen Rauf"
Objective: Understanding how glioma patients value cognitive outcomes is essential to personalizing their treatment plans. The purpose of this study was to identify the modifiable cognitive functions most affected by treatment and most important to patient quality of life.
Methods: Patients with gliomas were prospectively enrolled in focus groups and individual interviews using a standardized guide focusing on cognitive functions until saturation was achieved.
Article Synopsis
- This study investigates the effectiveness of combining EGFR-directed tyrosine kinase inhibitors (TKIs) with radiotherapy methods (WBRT and SRS) for treating brain metastases in patients with non-small cell lung cancer (NSCLC) carrying EGFR mutations.
- Over the course of the research, 239 patients were analyzed, revealing that those treated with SRS alone had significantly better overall survival compared to those receiving only WBRT.
- The results showed that while EGFR-TKI treatments, especially combined with SRS, showed promise, they did not significantly improve survival compared to SRS alone in this patient cohort.
Functional precision medicine platforms are emerging as promising strategies to improve pre-clinical drug testing and guide clinical decisions. We have developed an organotypic brain slice culture (OBSC)-based platform and multi-parametric algorithm that enable rapid engraftment, treatment, and analysis of uncultured patient brain tumor tissue and patient-derived cell lines. The platform has supported engraftment of every patient tumor tested to this point: high- and low-grade adult and pediatric tumor tissue rapidly establishes on OBSCs among endogenous astrocytes and microglia while maintaining the tumor's original DNA profile.
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- * A study involving 239 NSCLC patients with brain metastases identified that 107 received either first-generation or third-generation EGFR-TKIs, with 77.6% receiving treatments as first-line options and 30.8% in subsequent lines (2nd-5th).
- * Analysis revealed that the median overall survival for patients in first-line therapy was similar between first-generation (18.2 months) and third
Steroids are often utilized to manage patients with non-small cell lung cancer brain metastases (NSCLCBM). Steroids and elevated neutrophil-to-lymphocyte ratio (NLR) have been associated with decreased overall survival (OS) in patients treated with immune checkpoint inhibitors (ICI). We retrospectively investigated patients treated with ICI after the diagnosis of NSCLCBM at a single tertiary care institution examing the impact of steroids and NLR.
View Article and Find Full Text PDFThe development of brain metastases occurs in 10-20% of all patients with cancer. Brain metastases portend poor survival and contribute to increased cancer mortality and morbidity. Despite multimodal treatment options, which include surgery, radiotherapy, and chemotherapy, 5-year survival remains low.
View Article and Find Full Text PDFWe review the development of neurosurgery at the Medical University of South Carolina (MUSC) and the emergence of MUSC as a leading academic neurosurgical center in South Carolina. Historical records from the Waring Historical Library were studied, former and current faculty members were interviewed, and the personal records of Dr Phanor J Perot were examined. Dr Frederick E Kredel was the first to perform cerebral revascularization in stroke patients using omental flaps and the first to culture glioma cells in artificial media.
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