Publications by authors named "Yasmeen Mahmoud"
A Systematic Review of Novel Therapies of Pulmonary Arterial Hypertension.
Am J Cardiovasc Drugs
January 2024
Article Synopsis
- - Pulmonary arterial hypertension (PAH) is a serious, progressive condition that causes increased pressure in the lungs, leading to heart failure, and researchers are exploring new treatments to alleviate symptoms and improve patient outcomes.
- - This systematic review analyzed 8 randomized controlled trials focusing on the effectiveness of various potential treatments, including Rho-kinase inhibitors, BMP2 inhibitors, estrogen inhibitors, and AMPK activators, but faced challenges in conducting a meta-analysis due to differences in study designs and outcome measures.
- - Key findings suggest that metformin and the BMP2 inhibitor sotatercept show promise for modifying PAH, while the effects of other drugs, such as fasudil and anastrozole, require further long-term study to
Background: Classical homocystinuria due to cystathionine β-synthase (CBS) deficiency (OMIM 236200) is a recessively inherited condition caused by mutations in the CBS gene. The founder mutation p.R336C accounts for almost all CBS deficiency in Qatar, affecting approximately 1 in 1,800 births, making it the most prevalent monogenic disease among the Qatari population.
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