Effects of fisetin on ethanol-induced rewarding properties in mice.

Alcohol use disorder (AUD) is a chronic relapsing disorder associated with compulsive drinking of alcohol. Natural flavonoid fisetin affects a variety of transmitter systems relevant to AUD, such as aminobutyric acid, N-methyl-D-aspartate, and dopamine, as well as peroxisome proliferator-activated receptors. This study investigated fisetin's impact on the motivational properties of ethanol using conditioned place preference (CPP) in mice ( = 50).