Reevaluating the energy cost in locomotion: quadrupedal vs. bipedal walking in humans.

This study examines the energy expenditure and physiological responses associated with short-term quadrupedal locomotion compared to bipedal walking in humans. It aims to support evolutionary theory and explore quadrupedal locomotion's potential for enhancing fitness and health. In a randomized crossover design, 12 participants performed quadrupedal and bipedal walking on a treadmill at identical speeds.

The metabolic effects of habitual leg shaking: A randomized crossover trial.

Aims: The adverse effects of sedentary behavior on obesity and chronic diseases are well established. However, the prevalence of sedentary behavior has increased, with only a minority of individuals meeting the recommended physical activity guidelines. This study aimed to investigate whether habitual leg shaking, a behavior traditionally considered unfavorable, could serve as an effective strategy to improve energy metabolism.

NANOG has a role in mesenchymal stem cells' immunomodulatory effect.

It is well known that terminally differentiated cells derived from mesenchymal stem cells (MSCs) will lose the immunomodulation capacity. NANOG is known to be a core transcription factor in the maintenance of stem cell specific features or stemness. To evaluate whether NANOG was involved in the immunomodulation effects of MSCs, MSCs' immunomodulation capacity on lymphocyte activation and proliferation before or after endogenous NANOG interference was investigated.

Inhibition of hepatic stellate cells proliferation by mesenchymal stem cells and the possible mechanisms.

Aim: During fibrosis, hepatic stellate cells (HSCs) undergo a complex activation process characterized by increased proliferation and extracellular matrix deposition. Previous studies have suggested that mesenchymal stem cells (MSCs) may ameliorate fibrogenesis and represent a promising strategy for cell therapy. However, the underlying mechanisms are not fully understood.

New hope for cancer treatment: exploring the distinction between normal adult stem cells and cancer stem cells.

For decades, intensive studies have attempted to identify the mechanisms underlying malignant tumor growth. Despite significant progress, most therapeutic approaches fail to eliminate all tumor cells. The remaining tumor cells often result in recurrence and metastasis.