A study protocol for a randomised controlled trial of ice to reduce the pain of immunisation: The ICE trial.

Background And Objectives: Vaccine injections commonly cause iatrogenic pain. Ice may reduce pain. This is a study protocol for a prospective randomised controlled trial aiming to investigate the efficacy of ice packs to decrease vaccine-related pain in adults.

A Randomised Controlled Trial of Ice to Reduce the Pain of Immunisation-The ICE Trial.

Background And Objectives: vaccine injections are a common cause of iatrogenic pain and anxiety, contributing to non-compliance with scheduled vaccinations. With injection-related pain being recognised as a barrier to vaccination uptake in both adults and children, it is important to investigate strategies to effectively reduce immunisation pain. This prospective randomised controlled trial investigated the effects of applying an ice pack on vaccine-related pain in adults.

Cooling to reduce the pain associated with vaccination: A systematic review.

Background: Vaccine injections are the most common cause of iatrogenic pain in childhood and a cause of anxiety in adulthood. Skin cooling techniques, including icepacks and vapocoolants, may provide pain relief during intramuscular injections.

Objective: To identify the effects of skin cooling techniques on pain associated with immunisation.