Rates of PSMA PET Staging and Positivity in Newly Diagnosed Prostate Cancer in a National Health Care System.

Prostate-specific membrane antigen (PSMA) PET was approved by the U.S. Food and Drug Administration in 2020 for the staging of newly diagnosed prostate cancer, yet rates of adoption and real-world positivity rates are unknown.

Long non-coding RNAs: an overview on miRNA sponging and its co-regulation in lung cancer.

Lung cancer is the most devastating cause of death among all cancers worldwide, and non-small cell lung cancer (NSCLC) accounts for 80% of all the lung cancer cases. Beyond common genetic research and epigenomic studies, the extraordinary investigations of non-coding RNAs have provided insights into the molecular basis of cancer. Existing evidence from various cancer models highlights that the regulation of non-coding RNAs is crucial and that their deregulation may be a common reason for the development and progression of cancer, and competition of cancer therapeutics.

Imaging Manifestations of Ankle Impingement Syndromes.

Ankle impingement syndromes encompass various pathologic entities that contribute to ankle pain with limited range of motion. Although classically described in athletes, these changes can occur in individuals of all ages, often with a history of prior ankle trauma. Ankle impingement is broadly categorized as anterolateral, anterior, posterior, anteromedial, and posteromedial, depending on the area of the ankle affected.

BH4 improves postprandial endothelial function after a high-fat meal in men and postmenopausal women.

Objective: The timing and duration of menopause is important when evaluating the risk for cardiovascular disease in postmenopausal women, likely related in part to nitric oxide (NO) bioavailability. The flow-mediated dilation (FMD) test is a noninvasive assessment of NO bioavailability in humans, and tetrahydrobiopterin (BH4) is essential for NO synthesis. A high-fat meal (HFM) has been used to increase lipemia and reduce NO bioavailability.

Vitamin D3 supplementation for 16 weeks improves flow-mediated dilation in overweight African-American adults.

Background: A growing body of evidence has linked vitamin D deficiency to increased risk of cardiovascular disease. Vitamin D deficiency is also more common in African Americans for whom an increased cardiovascular disease risk exists. This study sought to test the hypothesis that 16 weeks of 60,000 IU monthly supplementation of oral vitamin D(3) would improve flow-mediated dilation (FMD) in African Americans, whereas no change would be observed in the placebo group.