Publications by authors named "Yashaswat Malhotra"
Article Synopsis
- Coronary artery disease (CAD) is a major global health issue influenced by genetic and environmental factors, with over 250 genetic risk loci identified, but the specific causal variants remain largely unexplored, especially in macrophages.
- The study utilized advanced single-cell RNA sequencing and multiomics to analyze human macrophages in relation to foam cell formation, assessing the genetic contributions to CAD across different macrophage subpopulations.
- Key findings revealed 18,782 cis-regulatory elements and identified 121 CAD-related genetic variants, particularly in a unique CD52-hi macrophage subtype, which plays a significant role in lipid handling and atherogenesis, highlighting the importance of macrophage diversity in CAD risk.
