Background: Apicomplexa consist of numerous pathogenic parasitic protistan genera that invade host cells and reside and replicate within the parasitophorous vacuole (PV). Through this interface, the parasite exchanges nutrients and affects transport and immune modulation. During the intracellular life-cycle, the specialized secretory organelles of the parasite secrete an array of proteins, among which dense granule proteins (GRAs) play a major role in the modification of the PV.
View Article and Find Full Text PDFIn recent years, the occurrence of peritoneal dialysis (PD)-associated peritonitis (PDAP) with Escherichia coli infection has gradually increased. The presence of quorum sensing (QS) among bacteria facilitates the expansion of antibiotic resistance. Brominated furanone (BMF), a halogenated furanone compound isolated from macroalgae, is a new type of quorum-sensing inhibitor that can inhibit bacterial quorum sensing and reduce bacterial resistance.
View Article and Find Full Text PDFPyroptosis is induced following inflammation via activation of the NLRP3 inflammasome. Lipopolysaccharide (LPS)-induced acute inflammation causes pyroptosis in renal tubular epithelial cells, which aggravates kidney damage and is involved in physiopathological processes in multiple renal diseases. Metadherin (Mtdh) induces inflammation by NLRP3 inflammasome activation.
View Article and Find Full Text PDFNephrology (Carlton)
November 2015
Aim: Numerous studies have examined and reported a high prevalence of chronic kidney disease (CKD) in the general population in various countries including China. However, the situation may be different in undeveloped rural minority regions in China because of China's economic diversity. The aim of the present study was to estimate the prevalence of CKD and to analyze its associated factors in a Zhuang ethnic minority area in Southwest China.
View Article and Find Full Text PDFZhonghua Xin Xue Guan Bing Za Zhi
September 2013
Objective: To observe the risk factors and prevalence status of hypertension at the Guangxi Zhuang-rural region.
Methods: Through cross-sectional survey, Xinlan village (Ethnic-Zhuang tribe village) in Liangqing District of Nanning was chosen as survey site. Select Zhuang-ethnic villagers (age ≥ 18 years, living time ≥ 6 months per year) as survey subjects.