An Immunohistochemical Analysis for Evaluating the Diagnostic Role of Myofibroblasts in Oral Squamous Cell Carcinoma using α-Smooth Muscle Actin Antibody.

Background: One of the most common types of malignancies affecting the head and neck region is oral squamous cell carcinoma (OSCC). Little less is known about the role of myofibroblasts in the pathogenetic process of OSCC. Hence, we assessed the involvement of myofibroblasts in the invasive process of OSCC using α-SMA (α-smooth muscle actin) antibody.

Establishment of the role of myofibroblasts in invasive process of oral squamous cell carcinoma: A pilot study.

Aims: To establish the role of myofibroblasts in invasive process of oral squamous cell carcinoma (OSCC).

Materials And Methods: Four study groups were formed as follows: group 1 consisting of 30 cases of well-differentiated OSCC, group 2 consisting of 30 cases of moderately differentiated OSCC, group 3 consisting of 30 cases of poorly differentiated OSCC, and group 4 consisting of controls. Staining of all of the specimens was done using a-SMA antibody through immunohistochemistry (IHC) procedure.