Publications by authors named "Yasasvi Wijewantha"
Synergy Between NK Cells and Monocytes in Potentiating Cardiovascular Disease Risk in Severe COVID-19.
Arterioscler Thromb Vasc Biol
October 2024
Background: Evidence suggests that COVID-19 predisposes to cardiovascular diseases (CVDs). While monocytes/macrophages play a central role in the immunopathogenesis of atherosclerosis, less is known about their immunopathogenic mechanisms that lead to CVDs during COVID-19. Natural killer (NK) cells, which play an intermediary role during pathologies like atherosclerosis, are dysregulated during COVID-19.
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- Severe COVID-19 infection is linked to a higher risk of cardiovascular disease (CVD), potentially due to an imbalanced immune response.
- Monocytes and macrophages are vital in the development of atherosclerosis, which is a key factor in ischemic CVD.
- Research shows that during and after severe COVID-19, proinflammatory monocytes and activated natural killer (NK) cells work together to promote the uptake of harmful substances in blood vessels, contributing to plaque build-up even after recovering from the virus.
The new pandemic virus SARS-CoV-2 emerged in China and spread around the world in <3 months, infecting millions of people, and causing countries to shut down public life and businesses. Nearly all nations were unprepared for this pandemic with healthcare systems stretched to their limits due to the lack of an effective vaccine and treatment. Infection with SARS-CoV-2 can lead to Coronavirus disease 2019 (COVID-19).
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