Publications by authors named "Yasaman Shokri"
Lung cancer (LC) is the most common cause of cancer-related death worldwide. Patients with LC are usually diagnosed at advanced phases. Five-year survival rate in LC patients is approximately 16%.
View Article and Find Full Text PDFBackground And Aims: Developing laboratory assays to evaluate HDL functions and improve cardiovascular disease (CVD) risk assessment has recently emerged as a challenge. The present study was conducted to help predict the risk of coronary artery disease (CAD) by investigating new cardiometabolic risk factors based on substituting paraoxonase 1 (PON1) as a critical enzyme in the functionality of HDL for that of HDL-C.
Methods And Results: The present study recruited 274 subjects undergoing diagnostic coronary angiography, 92 without significant CAD (non-CAD), and 182 with a severe CAD.
Oxidant-antioxidant imbalance is involved in the etiology of different diseases, including cardiovascular diseases (CVDs), liver disorders, kidney diseases, cancers and diabetes mellitus. Antioxidant enzymes play a key role in striking an oxidant-antioxidant balance. Moreover, paraoxonase 1 (PON1) is an antioxidant enzyme that binds with high-density lipoprotein (HDL) in the circulation, and antioxidant and antiaterogenic properties of this lipoprotein are significantly associated with PON1.
View Article and Find Full Text PDFArticle Synopsis
- The study assesses the roles of serum paraoxonase 1 (PON1), myeloperoxidase (MPO), and their ratio (MPO/PON1) in predicting coronary artery disease (CAD) by comparing their diagnostic capabilities.
- Results showed PON1 and the MPO/PON1 ratio had better diagnostic performance for CAD than MPO alone, particularly in patients aged 52 to 60.
- The findings suggest that PON1 may serve as an independent predictor for more severe multi-vessel disease and indicates that targeting PON1 and MPO could be beneficial in CAD prevention.