Cartilage and bone injectable hydrogels: A review of injectability methods and treatment strategies for repair in tissue engineering.

Cartilage and bone are crucial tissues causing disability in the elderly population, often requiring prolonged treatment and surgical intervention due to limited regenerative capacity. Injectable hydrogels that closely mimic the extracellular matrix (ECM) of native hard tissue have attracted attention due to their minimally invasive application and ability to conform to irregular defect sites. These hydrogels facilitate key biological processes such as cell migration, chondrogenesis in cartilage repair, osteoinduction, angiogenesis, osteoconduction, and mineralization in bone repair.

The effect of conductive aligned fibers in an injectable hydrogel on nerve tissue regeneration.

Injectable hydrogels are a promising treatment option for nervous system injuries due to the difficulty to replace lost cells and nervous factors but research on injectable conductive hydrogels is limited and these scaffolds have poor electromechanical properties. This study developed a chitosan/beta-glycerophosphate/salt hydrogel and added conductive aligned nanofibers (polycaprolactone/gelatin/single-wall carbon nanotube (SWCNT)) for the first time and inspired by natural nerve tissue to improve their biochemical and biophysical properties. The results showed that the degradation rate of hydrogels is proportional to the regrowth of axons and these hydrogels' mechanical (hydrogels without nanofibers or SWCNTs and hydrogels containing these additions have the same Young's modulus as the brain and spinal cord or peripheral nerves, respectively) and electrical properties, and the interconnective structure of the scaffolds have the ability to support cells.

Step-by-step fabrication of heart-on-chip systems as models for cardiac disease modeling and drug screening.

Cardiovascular diseases are caused by hereditary factors, environmental conditions, and medication-related issues. On the other hand, the cardiotoxicity of drugs should be thoroughly examined before entering the market. In this regard, heart-on-chip (HOC) systems have been developed as a more efficient and cost-effective solution than traditional methods, such as 2D cell culture and animal models.

Targeted pulmonary drug delivery in coronavirus disease (COVID-19) therapy: A patient-specific in silico study based on magnetic nanoparticles-coated microcarriers adhesion.

Since the beginning of the COVID-19 pandemic, nearly most confirmed cases develop respiratory syndromes. Using targeted drug delivery by microcarriers is one of the most important noteworthy methods for delivering drugs to the involved bronchi. This study aims to investigate the performance of a drug delivery that applies microcarriers to each branch of the lung under the influence of a magnetic field.