Tension-induced adhesion mode switching: the interplay between focal adhesions and clathrin-containing adhesion complexes.

Integrin-based adhesion complexes are crucial in various cellular processes, including proliferation, differentiation, and motility. While the dynamics of canonical focal adhesion complexes (FAs) have been extensively studied, the regulation and physiological implications of the recently identified clathrin-containing adhesion complexes (CCACs) are still not well understood. In this study, we investigated the spatiotemporal mechanoregulations of FAs and CCACs in a breast cancer model.

Dynamic interplay between cell membrane tension and clathrin-mediated endocytosis.

Deformability of the plasma membrane, the outermost surface of metazoan cells, allows cells to be dynamic, mobile and flexible. Factors that affect this deformability, such as tension on the membrane, can regulate a myriad of cellular functions, including membrane resealing, cell motility, polarisation, shape maintenance, membrane area control and endocytic vesicle trafficking. This review focuses on mechanoregulation of clathrin-mediated endocytosis (CME).

Transition from Continuous to Discontinuous Shear Thickening: An Excluded-Volume Effect.

In this Letter, we present a new mechanism under the action of which a shear thickening suspension transitions from a continuous to a discontinuous regime. This transition occurs by adding high concentrations of large spheres to a continuous shear thickening suspension. We show that the solid volume fraction of the interstitial shear thickening matrix is locally enhanced due to the presence of large particles and the excluded-volume shells surrounding the large particles, thus leading to a continuous to discontinuous shear thickening transition at the local scale.