Pregnancy complications in G20210A mutation carriers associated with high prothrombin activity.

Objective: To study the association between high activity of Factor II (prothrombin) in blood plasma with G20210A mutation and the development of great obstetrical syndromes.

Material And Methods: A prospective clinical cohort study was conducted on 290 pregnant women (average age 31.7 ± 4.

Clinical and laboratory manifestations of the prothrombin gene mutation in women of reproductive age.

Research Objective: To research the association of prothrombin (factor II) activity given the prothrombin G20210A mutation carriage with its clinical manifestations as thrombotic complications.

Materials And Methods: A prospective clinical cohort study of 290 women of reproductive age was conducted. Two cohort groups were identified: the study group of 140 patients with prothrombin mutation G20210A genotype and the control group of 150 women with G20210G genotype.