Publications by authors named "Yarui Pan"
Background And Purpose: Although a large collection of data has shown that ginsenosides, the major active ingredients from Ginseng, have neuroprotective and anti-depressant effect, the mechanism of action is incompletely understood. This study aims to elucidate the antidepressant mechanism of ginsenoside Rg1 (Rg1), a poorly absorbed ginsenoside, from the perspective of gut microbe to brain signaling.
Methods: A mouse model of depression was induced by unpredictable mild stress (UMS).
Article Synopsis
- * This study uses advanced techniques like transcriptomic analysis and machine learning to find key genetic changes and co-expression patterns in the brain region linked to MDD, particularly focusing on astrocytes.
- * The research identifies important genes that could be targets for new treatments and develops a predictive model for assessing the risk of MDD, ultimately aiming to improve therapeutic options for the disorder.