Neuroticism is associated with future disease and mortality risks.

Background: Neuroticism has been associated with numerous health outcomes. However, most research has focused on a single specific disorder and has produced controversial results, particularly regarding mortality risk. Here, we aimed to examine the association of neuroticism with morbidity and mortality and to elucidate how neuroticism affects trajectories from a healthy state, to one or more neuroticism-related disorders, and subsequent mortality risk.

Bach1 Deficiency Ameliorates Radiation Pneumonitis via Activating TFAM Signaling Pathway.

BTB and CNC homology 1 (Bach1) is a transcription factor that mediates oxidative stress and inflammation and participates in the progression of diseases such as atherosclerosis, colitis, and acute lung injury. In this study, we aimed to explore the role of Bach1 in radiation pneumonitis (RP) and elucidate its underlying mechanism. Bach1 expression was significantly elevated in the lung tissues of RP mice.

Cascade-Type Microglial Pyroptosis Inhibitors for Enhanced Treatment of Cerebral Ischemia-Reperfusion Injury.

Neuroinflammation is a critical factor in the progression of cerebral ischemia-reperfusion injury (CIRI). Pyroptosis, which is an inflammatory form of programmed cell death, greatly amplifies neuroinflammatory processes. It does so by promoting the release of various inflammatory contents that intensify the overall inflammatory response within the central nervous system.

Ozone exposure induced kidney damage in diabetic mice: The key role of lipid metabolism and water-electrolyte homeostasis.

Ozone (O) is an important environmental pollutant that has garnered growing public concern. Epidemiological studies indicate that exposure to O is associated with an elevated risk of kidney disease, a common complication of diabetes. However, the harmful effects of O on the kidneys remain unconfirmed.

Clinical, radiological, pathological and prognostic features of general paresis: a cohort study.

General paresis is a rare type of syphilis characterized by progressive cognitive impairment and psychiatric syndromes. It is often misdiagnosed because of its rarity and similarity with other diseases. We aimed to comprehensively investigate the clinical, radiological, pathological, and prognostic features of general paresis, and compare it with other dementias.

TCGAN: Temporal Convolutional Generative Adversarial Network for Fetal ECG Extraction Using Single-Channel Abdominal ECG.

Noninvasive fetal ECG (FECG) monitoring holds significant importance in ensuring the normal development of the fetus. Since FECG is usually submerged by maternal ECG (MECG) and background noise in abdominal ECG (AECG), it is challenging to exactly restore the waveform details of FECG from AECG. To address this issue, a temporal convolutional generative adversarial network (TCGAN) is proposed for FECG extraction using single-channel AECG.

ATP-Exhausted Strategy Induced Anti-Tumor Low-Temperature Photothermal Therapy Based on Rare Earth Nanocrystals Modified Hollow Porous MnO Nanozyme with TME-Activated NIR-II Imaging.

Insufficient adenosine triphosphate (ATP) can reduce the synthesis of heat-stress-induced heat shock proteins (HSPs) to promote the efficiency of mild photothermal therapy (mPTT), thus the rational design of ATP-exhausted strategy based on nanotechnology is an effective approach to resuscitate mPTT. Herein, Nd doped nanocrystals (NaYF:Nd@CaF, Nd-NCs) modified hollow mesoporous manganese oxide (H-MnO) nanocomposite (H-MnO@Nd-NCs, MN) is synthesized, and loaded with glucose transporters (GLUTs) inhibitor KL-11743, noted as MN-KL nanozyme. In tumor microenvironment (TME), MN-KL can react with overexpressed glutathione (GSH) to release KL-11743, which can suppress the synthesis of intracellular ATP at the source by blocking glucose uptake to inhibit HSPs expression, meanwhile, MN-KL catalyzes the production of ·O /O/·OH and lipid peroxidation (LPO) to cleave existing HSPs.

Neuronal FAM171A2 mediates α-synuclein fibril uptake and drives Parkinson's disease.

Neuronal accumulation and spread of pathological α-synuclein (α-syn) fibrils are key events in Parkinson's disease (PD) pathophysiology. However, the neuronal mechanisms underlying the uptake of α-syn fibrils remain unclear. In this work, we identified as a PD risk gene that affects α-syn aggregation.

Generation of suspension cell cultures with high syringin content and anti-inflammatory activity through overexpressing glycotransferase SiUGT72BZ2 in Saussurea involucrata.

The snow lotus species Saussurea involucrata (Kar. & Kir.) Sch.

Single Cell Inference of Cancer Drug Response Using Pathway-Based Transformer Network.

Accurate prediction of cancer drug responses is crucial for personalized therapy. Single-cell RNA sequencing (scRNA-seq) captures cellular heterogeneity and rare resistant populations, offering valuable insights into treatment responses. However, the distinct distributions of bulk RNA-seq and scRNA-seq data hinder the transfer of drug response knowledge from large-scale cell line datasets.

Efficient removal of enrofloxacin in swine wastewater using eukaryotic-bacterial symbiotic membraneless bioelectrochemical system.

A eukaryotic-bacterial symbiotic membraneless bioelectrochemical system (EBES) reactor with eukaryotic-bacteria symbiotic cathode was developed to treat swine wastewater containing enrofloxacin (ENR), which had high performance at ENR tolerance and operational stability. With ENR concentrations shifting from 2 to 50 mg/L, the removal efficiencies of ENR, chemical oxygen demand (COD) and NH-N always were higher than 95 %, and the maximum power output (≥343 mW/m) could be achieved. At 20 mg/L ENR, the removal efficiencies of ENR, COD and NH-N respectively reached to 99.

-Mediated Insulin Signaling Pathway Was Involved in O-Induced Multigenerational Effects of Shortened Lifespan in .

As a long-standing atmospheric pollutant, ozone (O) exerts enduring effects on biological health. However, experimental research on its impact on organism lifespan and generational effects is limited. This study exposed three generations of fruit flies () to O, revealing a shortened lifespan across generations.

Systematic dissection of pleiotropic loci and critical regulons in excitatory neurons and microglia relevant to neuropsychiatric and ocular diseases.

Advancements in single-cell multimodal techniques have greatly enhanced our understanding of disease-relevant loci identified through genome-wide association studies (GWASs). To investigate the biological connections between the eye and brain, we integrated bulk and single-cell multiomic profiles with GWAS summary statistics for eight neuropsychiatric and five ocular diseases. Our analysis uncovered five latent factors explaining 61.

Genome-wide association study unravels mechanisms of brain glymphatic activity.

Brain glymphatic activity, as indicated by diffusion-tensor imaging analysis along the perivascular space (ALPS) index, is involved in developmental neuropsychiatric and neurodegenerative diseases, but its genetic architecture is poorly understood. Here, we identified 17 unique genome-wide significant loci and 161 candidate genes linked to the ALPS-indexes in a discovery sample of 31,021 individuals from the UK Biobank. Seven loci were replicated in two independent datasets.

Metabolomic and Transcriptomic Analysis Reveals Flavonoid-Mediated Regulation of Seed Antioxidant Properties in Peanut Seed Vigor.

Peanut ( L.) is an oilseed crop grown worldwide. Flavonoids have profound benefits for plant growth and development because of their powerful antioxidant properties.

Epilepsy and brain health: a large prospective cohort study.

Background: Epilepsy, as a chronic noncommunicable disease with recurrent seizures, may be a marker of deterioration or alteration in other underlying neurological diseases. This study aimed to investigate the relationship of epilepsy with brain function, other common brain disorders, and their underlying mechanisms.

Methods: The study was based on clinical diagnostic and test data from 426,527 participants in the UK Biobank, of whom 3,251 were diagnosed with epilepsy at baseline.

Identifying proteins and pathways associated with multimorbidity in 53,026 adults.

Background And Aims: Multimorbidity, the coexistence of multiple chronic diseases, is a rapidly expanding global health challenge, carrying profound implications for patients, caregivers, healthcare systems, and society. Investigating the determinants and drivers underlying multiple chronic diseases is a priority for disease management and prevention.

Method: This prospective cohort study analyzed data from the 53,026 participants in the UK Biobank from baseline (2006 to 2010) across 13.

Enhanced waste-to-biomass conversion and reduced nitrogen emissions for black soldier fly larvae (Hermetia illucens) through modifying protein to energy ratio.

The appropriate protein to energy ratio (P/E ratio) has played a crucial role in maximizing waste-to-biomass conversion and minimizing nitrogen emissions. Black soldier fly larvae (Hermetia illucens, BSFL), capable of converting organic wastes into nutrient-rich biomass, it has the potential to become an innovative solution to reduce environmental impacts and optimize waste resource utilization. However, the appropriate P/E ratio for BSFL in the waste treatment process has remained unknown so far.

Effects of different enzymatic hydrolysis techniques on volatile flavor compounds and nutritional metabolites of soybean meal yogurt.

Background: This study explores enzymatic hydrolysis as a method of modifying soybean meal (SM). It can reduce the particle size, improve flavor, and convert macromolecules into absorbable nutrients. The purpose is to provide technical information regarding the use of SM.

Atlas of the plasma proteome in health and disease in 53,026 adults.

Large-scale proteomics studies can refine our understanding of health and disease and enable precision medicine. Here, we provide a detailed atlas of 2,920 plasma proteins linking to diseases (406 prevalent and 660 incident) and 986 health-related traits in 53,026 individuals (median follow-up: 14.8 years) from the UK Biobank, representing the most comprehensive proteome profiles to date.

Quadruple Stimuli-Responsive Behaviour of Acylhydrazone Crystals: Mechanical, Photomechanical, Thermomechanical, and Optical Waveguide Properties.

As society advances, the demand for high-performance crystal materials with versatile stimuli-responsive capabilities has increased. However, there remains a notable shortage of simple molecular crystals that exhibit stable and swift responses to various stimuli. In this study, we synthesized a novel acylhydrazone crystal by integrating benzene-fused heterocycles and halogens, achieving a crystal material with multiple stimuli-responsive behaviours.

Large-scale proteomic analyses of incident Alzheimer's disease reveal new pathophysiological insights and potential therapeutic targets.

Pathophysiological evolutions in early-stage Alzheimer's disease (AD) are not well understood. We used data of 2923 Olink plasma proteins from 51,296 non-demented middle-aged adults. During a follow-up of 15 years, 689 incident AD cases occurred.

Organophosphate Insecticide Malathion Induces Alzheimer's Disease-Like Cognitive Impairment in Mice: Evidence of the Microbiota-Gut-Brain Axis.

Evidence suggests that exposure to organophosphate pesticides increases the risk of neurodegenerative diseases, but the mechanisms remain unclear. This study investigated the effects of malathion on Alzheimer's disease (AD)-like symptoms at environmentally relevant concentrations using wild-type (WT) and APP/PS1 transgenic mouse models. Results showed that malathion exposure induced AD-like cognitive impairment, amyloid-β (Aβ) accumulation, and neuroinflammation in WT mice, with worsened symptoms in APP/PS1 mice.

Identification of Potential Biomarkers Associated with Spermatogenesis in Azoospermia.

Background: Azoospermia, characterized by the absence of spermatozoa in the ejaculate, affects approximately 1% of all men and 10 - 15% of infertile males, representing the most severe form of male infertility. It is classified into obstructive azoospermia (OA) and nonobstructive azoospermia (NOA), with the latter often resulting from unexplained failures in spermatogenesis. This study endeavored to clarify the molecular underpinnings of sper-matogenesis in NOA and to identify viable therapeutic targets.