Publications by authors named "Yaru Yang"

A femtosecond pulse downconverts broadband electromagnetic signals to the hundreds of MHz range, enabling fast measurement and enhancing electromagnetic monitoring efficiency. However, due to the high peak power of optical pulses, the received power of the detector is severely limited, and thus the sensitivity of the system is reduced. To address this problematic issue, this paper presents a multichannel parallel high-saturation optical power-balanced photodetection technique that uses parallel reception to enhance the detector's received power, thereby improving the signal-to-noise ratio (SNR) and system sensitivity.

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Cilia are highly specialized cellular projections emanating from the cell surface, whose defects contribute to a spectrum of diseases collectively known as ciliopathies. Intraflagellar transport protein 88 (IFT88) is a crucial component of the intraflagellar transport-B (IFT-B) subcomplex, a protein complex integral to ciliary transport. The absence of IFT88 disrupts the formation of ciliary structures; thus, animal models with IFT88 mutations, including the oak ridge polycystic kidney (ORPK) mouse model and IFT88 conditional allelic mouse model, are frequently employed in molecular and clinical studies of ciliary functions and ciliopathies.

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Objectives: To evaluate the frequency of erectile dysfunction in male patients who undergo thyroidectomy using the International Index of Erectile Function (IIEF-5), and explore possible risk factors.

Methods: 163 male patients who undergo partial, unilateral or bilateral thyroidectomy between December 2021 and September 2022 were retrospectively studied. The IIEF-5 questionnaires were completed 6 and 12 months after surgery, and patients who reported erectile dysfunction (ED) before surgery were not included.

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Pine wood nematodes (PWN, Bursaphelenchus xylophilus) cause widespread mortality in pine forests via pine wilt disease (PWD). The rapid death of diseased trees, which destroys biodiversity and significantly affects forest carbon storage, leading to negative environmental and economic consequences, as forests are crucial to the global carbon cycle. The interactions among PWN, hosts, and vector insects are closely linked to climate change.

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Ethnopharmacological Relevance: Chinese herbal medicine constitutes a substantial cultural and scientific resource for the Chinese nation, attracting considerable scholarly interest due to its intrinsic characteristics of "multi-component, multi-target, and multi-pathway" interactions. Simultaneously, it aligns accurately with the intricate and continuously evolving progression of non-small cell lung cancer (NSCLC). Furthermore, contemporary pharmacological studies indicate that natural herbaceous plants and their bioactive compounds exhibit a diverse array of biological activities, including antioxidant, anti-inflammatory, and anti-tumor effects, among others.

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Ambient hypoxia can pose a major threat to the survival of metazoan organisms, especially insect embryos. Hemocyanin exhibits dominant expression in insect embryos, but its specific roles in hypoxia adaptation remain unexplored. Soil-dwelling locust eggs may frequently experience hypoxia during development.

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Background: Although several models have been developed to predict postoperative pneumonia in elderly hip fracture patients, no systematic review of the model quality and clinical applicability has been reported.

Objective: To systematically review and critically appraise existing models for postoperative pneumonia in elderly hip fracture patients.

Design: Systematic review and meta-analysis.

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Article Synopsis
  • * Targeting mGluR7 with drugs like agonists, antagonists, and allosteric modulators shows promise for treating CNS disorders such as psychiatric and neurodegenerative diseases, although research is still in the early stages.
  • * This review highlights the structure and function of mGluR7 and discusses advancements in related drug therapies, aiming to deepen our understanding of neuroprotection mechanisms and develop effective treatment strategies.
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Background: SM-like (LSM) genes a family of RNA-binding proteins, are involved in mRNA regulation and can function as oncogenes by altering mRNA stability. However, their roles in B-cell progression and tumorigenesis remain poorly understood.

Methods: We analyzed gene expression profiles and overall survival data of 123 patients with mantle cell lymphoma (MCL).

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  • The study focuses on Polycystic Ovary Syndrome (PCOS), a common reproductive hormone disorder in women that can lead to a heightened risk of ovarian hyperstimulation syndrome (OHSS) during fertility treatments.
  • It included a retrospective analysis of 200 PCOS patients, with 118 exhibiting a high ovarian response (HOR) and 82 showing a normal response (NOR), revealing significant differences in hormone levels and characteristics between the two groups.
  • Key findings showed that HOR patients had higher levels of anti-Müllerian hormone (AMH) and displayed more oocytes and elevated inflammatory markers during controlled ovarian stimulation, suggesting the involvement of CCL25/CCR9 in high ovarian response.*
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  • SHR-1707 is a novel monoclonal antibody designed to target Aβ, aiming to reduce plaque formation in potential Alzheimer's disease treatment; preclinical tests in mice have shown promising results in decreasing Aβ deposits.* -
  • Two phase 1 clinical trials were conducted to assess SHR-1707 in healthy adults in China and Australia, focusing on safety, tolerability, and how the drug behaves in the body (pharmacokinetics and pharmacodynamics) after a single intravenous dose.* -
  • Results indicated that SHR-1707 was generally well-tolerated with mostly mild adverse effects reported; the drug showed a dose-dependent increase in plasma Aβ levels, with similar safety and body response profiles observed in both younger and
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  • This study compared the accuracy and time efficiency of different tally methods using MCNP6 for a novel x-ray tube designed for Auger electron yield with materials like iodine.
  • Key assessments included photon spectrum analysis, dose measurements in both air and water, and mass-energy absorption coefficients, showing slight variations in mean energy between different media.
  • The FMESH tally method demonstrated better efficiency over the F6 tally for dose calculations, which could enhance treatment planning systems by quickly generating necessary data for diverse physical conditions.
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  • Acute kidney injury (AKI) is characterized by a sudden decline in kidney function, leading to inflammation and cell damage.
  • The study investigates the effects of a DNA methyltransferase (DNMT) inhibitor, RG108, on kidney inflammation and injury induced by cisplatin and hypoxia-reoxygenation.
  • Results show that RG108 significantly reduces kidney inflammation and injury by inhibiting the P38 MAPK/FOS and JNK/JUN pathways, suggesting its potential as a new treatment for AKI.
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Biomass fly ash is a sustainable, eco-friendly cement substitute with economic and performance benefits, being renewable compared to coal fly ash. This study examines using biomass fly ash (BFA) as a sustainable cement substitute, comparing it with Class F fly ash (CFA). With a water-binder ratio of 0.

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In the backdrop of the rapid evolution of the digital economy, the intricate relationship between digital industry agglomeration (DIA) and manufacturing firms' carbon emissions has become crucial for countries to achieve sustainable development. This study delves into this complex dynamic by analyzing data from Chinese-listed manufacturing companies spanning the years 2014 to 2021. A regional-level DIA Index is calculated to explore its impact on manufacturing firms' carbon emissions.

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Developing efficient and eco-friendly technologies for treating the antibiotic wastewaters is crucial. At present, the catalysts with metal-nitrogen (M-N) coordination showed excellent Fenton-like performance but were always difficult to realize practical antibiotics degradation because of their complicated preparation methods and inferior stability. In this work, the Co-N configuration was facilely reconstructed on the surface of CoO (Co-N/CoO), which exhibited superior catalytic activity and stability towards various antibiotics.

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Currently, there are still many patients who require outpatient triage assistance. ChatGPT, a natural language processing tool powered by artificial intelligence technology, is increasingly utilized in medicine. To facilitate and expedite patients' navigation to the appropriate department, we conducted an outpatient triage evaluation of ChatGPT.

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  • Primary testicular lymphoma (PTL) is a rare type of lymphoma that mostly affects older men, has limited treatment response, and a high likelihood of relapse, with 90% of cases classified as diffuse large B-cell lymphomas (DLBCL).
  • A study involving whole-exome sequencing of 25 PTL patients identified common mutations in genes like HLA, CDKN2A, and MYD88, leading to the division of patients into two subtypes based on their molecular characteristics.
  • Notably, the C1 subtype, marked by TP53 mutations, showed better outcomes compared to the C2 subtype, which had deletions in immune-related genes, indicating that understanding these mutations can help predict prognosis and guide treatment
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  • * Among the 20 compounds, 7 were found for the first time in this plant, with their chemical structures determined using NMR and MS spectroscopy techniques.
  • * Notably, three of the isolated compounds showed significant cytotoxic effects on human cancer cell lines A549 and HepG2, suggesting potential anti-cancer properties.
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Periodontitis, which is related to various systemic diseases, is a chronic inflammatory disease caused by periodontal dysbiosis of the microbiota. Multiple factors can influence the interaction of periodontitis and associated inflammatory disorders, among which host immunity is an important contributor to this interaction. Innate immunity can be activated aberrantly because of the systemic inflammation induced by periodontitis.

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  • CCDC25 is found to be overexpressed in clear cell renal cell carcinoma (ccRCC) tissues and cell lines compared to normal tissues, indicating its potential role in cancer development.
  • Experiments showed that knocking down CCDC25 significantly inhibited tumor growth, migration, and invasion of cancer cells, while overexpressing it had the opposite effect.
  • The study suggests that CCDC25 interacts with integrin-linked kinase (ILK) to activate the NF-κB signaling pathway, making it a promising target for therapeutic interventions in ccRCC.
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  • China is the largest producer of crayfish, and there's a need to address heavy metal contamination, specifically cadmium (Cd), which poses risks to these organisms.
  • This study explored the use of Saccharomyces cerevisiae (a type of yeast) as a bioremediation tool to reduce Cd toxicity in crayfish by measuring antioxidant levels and oxidative stress markers.
  • Results showed that a 5% inclusion of S. cerevisiae in crayfish feed significantly improved Cd removal rates and overall antioxidant capacity, suggesting its potential for creating safer crayfish products.
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Desert ecosystems are sensitive to nitrogen (N) deposition. Considering snow is an important source of soil water, which is vital for plant growth and the biogeochemical cycle in desert areas. The effects of N deposition on biological soil crusts (BSCs) could be impacted by the removal of snow-cover.

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  • Cancer is caused by a series of genetic mutations and epigenetic changes, posing a major global health challenge.
  • Cytokines and chemokines, particularly the CXCL12-CXCR4/CXCR7 signaling pathway, are crucial in cancer development, affecting processes like tumor growth and spread.
  • This review focuses on the latest findings about the CXCL12-CXCR4/CXCR7 interactions and their potential as biomarkers or targets for new cancer therapies.
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