Therapeutic Targeting of P2X Receptors for Orofacial Pain.

P2X receptors (P2XRs), membrane ion channels activated by extracellular adenosine 5' -triphosphate (ATP), play a pivotal role in nociception by directly promoting pain signaling. Currently, antagonists targeting P2XRs have taken effect in alleviating various pain. The therapeutic potential of the P2X receptor family has become a central focus.

Solvent extraction of boron from mildly alkaline salt lake brine in Tibet, China.

Since the level of resource depletion is maintained at a high level, the recovery of boron from salt lake brine has become an effective way to meet the increasing demand for boron. This study investigates the optimization of boron extraction from the weakly alkaline brine of the Laguocuo Salt Lake (LGCSL) in Tibet, China, a representative of Tibetan weakly alkaline salt lakes. We evaluated the efficacy of 2,2,4-trimethyl-1,3-pentanediol (TMPD) as an extractant within a solvent mixture of 2-butyl-1-octanol (C-OH) and sulfonated kerosene.

Full-Dimensional Analysis of Gaseous Products to Unlocking In Depth Thermal Runaway Mechanism of Li-Ion Batteries.

In this study, state-of-the-art on-line pyrolysis MS (OP-MS) equipped with temperature-controlled cold trap and on-line pyrolysis GC/MS (OP-GC/MS) injected through high-vacuum negative-pressure gas sampling (HVNPGS) programming are originally designed/constructed to identify/quantify the dynamic change of common permanent gases and micromolecule organics from the anode/cathode-electrolyte reactions during thermal runaway (TR) process, and corresponding TR mechanisms are further perfected/complemented. On LiC anode side, solid electrolyte interphase (SEI) would undergo continuous decomposition and regeneration, and the R-H (e.g.

RAPSYN-mediated neddylation of BCR-ABL alternatively determines the fate of Philadelphia chromosome-positive leukemia.

Philadelphia chromosome-positive (Ph) leukemia is a fatal hematological malignancy. Although standard treatments with tyrosine kinase inhibitors (TKIs) have achieved remarkable success in prolonging patient survival, intolerance, relapse, and TKI resistance remain serious issues for patients with Ph leukemia. Here, we report a new leukemogenic process in which RAPSYN and BCR-ABL co-occur in Ph leukemia, and RAPSYN mediates the neddylation of BCR-ABL.

Adsorption of lithium ions from aqueous solution by magnetic aluminum-based adsorbents.

Magnetic aluminum-based adsorbents (MLDHs) were prepared with a coprecipitation method and used to separate lithium ions from the aqueous solutions. In static adsorption experiment, the adsorption capacity of MLDHs for lithium ions reached 8.22 mg/g.

Structural design and performance study of primitive triply periodic minimal surfaces Ti6Al4V biomimetic scaffold.

This paper comprehensively evaluated the static mechanical compressive properties, permeability, and cell adhesion effect on the inner wall of the Primitive triply periodic minimal surface Ti6Al4V bionic scaffolds with different axial diameter ratios through numerical simulation and experiments. The results show that when the axial diameter ratio is 1:2, the elastic modulus of the scaffold is about 1.25 and the yield strength is about 1.

Lighting for work: a study on the effect of underground low-light environment on miners' physiology.

Low-light environment affects human physiology, psychology, and behavior. It causes errors in work and increases accidents. In this study, we built a coal mine lighting simulation experiment system.

How to analyse the injury based on 24Model: a case study of coal mine gas explosion injury.

Background: Coal mine gas explosion injury has caused mass casualties, which have resulted in widespread concern.

Methods: In order to prevent gas explosion injury in coal mine, 24Model is proposed to analyse the risk in this paper. 24Model is a human-oriented and organisation-oriented risk analysis method.

A simulation experiment study to examine the effects of noise on miners' safety behavior in underground coal mines.

Background: Noise pollution in coal mines is of great concern. Personal injuries directly or indirectly related to noise occur from time to time. Its effects impact the health and safety of coal mine workers.

Optimization of extraction flavonoids from Exocarpium Citri Grandis and evaluation its hypoglycemic and hypolipidemic activities.

Ethnopharmacological Relevance: Exocarpium Citri Grandis (ECG; Huajuhong in Chinese) is a precious traditional Chinese medicine with a history of hundreds of years in China. It has been demonstrated to possess numerous pharmacological properties, including antitussive, expectorant, anti-inflammatory, hypoglycemic, and hypolipidemic. However, no in-depth report exists on the hypoglycemic and hypolipidemic properties of ECG.

Preparation and characterization of a novel colorimetric indicator film based on gelatin/polyvinyl alcohol incorporating mulberry anthocyanin extracts for monitoring fish freshness.

This work aimed to develop a novel colorimetric indicator film for monitoring of food freshness based on gelatin/polyvinyl alcohol matrix incorporated with anthocyanin extracts from mulberry. The color of anthocyanin extracts solutions obviously changed from bright red to dark green in the pH range of 2.0-11.

Inclusion Complex of Exocarpium Citri Grandis Essential Oil with β-Cyclodextrin: Characterization, Stability, and Antioxidant Activity.

The purpose of this study was to produce and characterize an inclusion complex between β-cyclodextrin (β-CD) and Exocarpium Citri Grandis essential oil (EEO), and to evaluate its antioxidant properties. The volatile compounds of EEO were characterized by gas chromatography-mass spectrometer. A comparison of the β-CD, EEO, and the physical mixture with the inclusion complex revealed differences in their thermal stabilities and morphologies, which confirmed the formation of the β-CD-EEO inclusion complex.

Dinuclear Lanthanide Complexes Based on a Schiff-base Ligand: Free Lattice Solvent Inducing the Single Molecule Magnet Behavior of Dy Compound.

Syntheses, crystal structures and magnetic properties are described for a series of seven-coordinate dinuclear lanthanide complexes of compositions Dy L (1) (H L=2-{[bis(2-hydroxy-3-ethoxybenzyl)(aminoethyl)amino]methyl}phenol) and Ln L ⋅MeCN (Ln=Dy (2), Sm (3), Eu (4), Gd (5), Tb (6), Ho (7)). The reaction of Dy(NO ) ⋅6 H O with one equivalent of H L at 70 °C in DMF/EtOH under autogenous pressure gave compound 1. Complexes 2-7 were prepared by means of the same method as that used for 1, except DMF was replaced by MeCN as the reaction solvent and Dy(NO ) ⋅6 H O was changed to the corresponding lanthanide salts.

Optimization of Extraction of Hypoglycemic Ingredients from Grape Seeds and Evaluation of α-Glucosidase and α-Amylase Inhibitory Effects In Vitro.

Unlabelled: Grape seeds full with oil and also rich in hypoglycemic ingredients. This study is to improve the comprehensive utilization of grape seeds and the quality of grape seeds oil. Extract water soluble active substances before extracting oil from grape seeds, which show the grape seeds in water soluble extracts containing TP, TC, PC contents, respectively, are 171.

A series of Ln clusters: Dy single molecule magnet and Tb multi-responsive luminescent sensor for Fe, CrO /CrO and 4-nitroaniline.

Five tetranuclear lanthanide clusters of compositions [LnL(NO)(Piv)]·2CHOH (Ln = Gd (1), Tb (2), Dy (3), Ho (4), Er (5); HL = 2-(((2-hydroxy-3-methoxybenzyl)imino)methyl)-6-methoxyphenol; Piv = pivalic acid) were synthesized under solvothermal conditions. The structures of 1-5 were characterized by single-crystal X-ray crystallography. Complexes 1-5 possess a zig-zag topology with [LnO] cores being formed by the fusion of oxygen atom-bridged two [LnO] moieties.

Two Series of Homodinuclear Lanthanide Complexes: Greatly Enhancing Energy Barriers through Tuning Terminal Solvent Ligands in Dy Single-Molecule Magnets.

The utilization of 2-ethoxy-6-{[(2-hydroxy-3-methoxybenzyl)imino]methyl}phenol (H L) as a chelating ligand, in combination with the employment of alcohols (EtOH and MeOH) as auxiliary ligands, in 4 f-metal chemistry afforded two series of dinuclear lanthanide complexes of compositions [Ln L (NO ) (EtOH) ] (Ln=Sm (1), Eu (2), Gd (3), Tb (4), Dy (5), Ho (6), Er (7)) and [Ln L (NO ) (MeOH) ] (Ln=Sm (8), Eu (9), Gd (10), Tb (11), Dy (12), Ho (13), Er (14)). The structures of 1-14 were determined by single-crystal X-ray crystallography. Complexes 1-7 are isomorphous.

Adipose-Derived Mesenchymal Stem Cells Ameliorate Lipid Metabolic Disturbance in Mice.

Unlabelled: : Adipose-derived mesenchymal stem cells (AD-MSCs) have been shown to ameliorate hyperglycemia in diabetic animals and individuals. However, little is known about whether AD-MSCs affect lipid metabolism. Here we have demonstrated for the first time that AD-MSC infusion can significantly suppress the increase in body weight and remarkably improve dyslipidemia in db/db obese mice and diet-induced obesity mice.

TLR4 plays a crucial role in MSC-induced inhibition of NK cell function.

Mesenchymal stem cells (MSC) are a kind of stromal cell within the tumor microenvironment. In our research, MSC derived from acute myeloid leukemia patients' bone marrow (AML-MSC) and lung cancer tissues (LC-MSC) as well as normal bone marrow-derived MSC (BM-MSC) cultured in conditioned medium of HeLa cells were found to have higher expressions of Toll-like receptor (TLR4) mRNA compared with BM-MSC. The sorted TLR4-positive MSC (TLR4+ MSC) differed in cytokine (interleukin-6, interleukin-8, and monocyte chemoattractant protein-1) secretion from those of unsorted MSC.

Short-term memory of danger signals or environmental stimuli in mesenchymal stem cells: implications for therapeutic potential.

Mesenchymal stem/stromal cells (MSCs) possess some characteristics of immune cells, including a pro-inflammatory phenotype, an immunosuppressive phenotype, antibacterial properties and the expression of Toll-like receptor proteins. Here we show that, similar to immune cells, MSCs retain information from danger signals or environmental stimuli for a period of time. When treated with the pro-inflammatory factors lipopolysaccharide (LPS) or tumor necrosis factor-α (TNF-α), MSCs display increased expression of IL-6, IL-8 and MCP-1.