Publications by authors named "Yarong Zeng"
Article Synopsis
- The Varicella zoster virus (VZV) causes chickenpox in children and can reactivate as shingles later in life, making vaccination crucial for prevention.
- Current vaccines based on attenuated strains can have side effects, and researchers explored a nanoparticle-based vaccine called FR-gE that shows promise in eliciting stronger immune responses.
- The FR-gE vaccine demonstrated significantly higher VZV-neutralizing antibody responses and a robust immune profile in mouse models compared to existing vaccines, indicating its potential as an effective alternative for preventing varicella and herpes zoster.
The cGAS-STING pathway and the Mevalonate Pathway are druggable targets for vaccine adjuvant discovery. Manganese (Mn) and bisphosphonates are known to exert adjuvant effects by targeting these two pathways, respectively. This study found the synergistic potential of the two pathways in enhancing immune response.
View Article and Find Full Text PDFIntroduction: Vaccines are powerful tools for controlling microbial infections and preventing epidemics. To enhance the immune response to antigens, effective subunit vaccines or mRNA vaccines often require the combination of adjuvants or delivery carriers. In recent years, with the rapid development of immune mechanism research and nanotechnology, various studies based on the optimization of traditional adjuvants or various novel carriers have been intensified, and the construction of vaccine adjuvant delivery systems (VADS) with both adjuvant activity and antigen delivery has become more and more important in vaccine research.
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