Protective role of (rs3758391 T > C) polymorphism against T2DM and its complications: Influence on GPx activity.

Background And Aims: Sirtuin-1 (SIRT1) has antidiabetic effects through the regulation of insulin secretion and modulation of inflammation. The rs3758391 gene polymorphism affects the level of SIRT1. The current study aimed to investigate the possible influence of gene variants in relation to oxidative stress parameters on the susceptibility to type 2 diabetes mellitus (T2DM) and its microvascular complications.

Assessment of TNF-α (-857 C/T) gene polymorphism in oral lichen planus disease: A case-control study.

Background And Aims: Oral lichen planus (OLP) is an inflammatory mucocutaneous disorder with an immune-mediated pathogenesis. The tumor necrosis factor-α (TNF-α) level in the serum of OLP patients is significantly higher than in the control group. TNF-α-857 C/T polymorphism can be related to the increased TNF-α level in blood circulation.

Methylation Status of cAMP-responsive Element Modulator (CREM) Gene in Infertile Men and Its Association with Sperm Parameters.

The methylation pattern of non-imprinting genes was little studied, although it is widely known that the abnormal methylation levels of imprinting genes are associated with different forms of male infertility. The purpose of this research was to assess the CREM gene's methylation status and seminal characteristics in infertile individuals who were potential intracytoplasmic sperm injection (ICSI) candidates. A total of 45 semen samples (15 normospermia, 15 asthenospermia, and 15 oligoasthenoteratospermia) were examined.

The influence of Nrf2 gene promoter methylation on gene expression and oxidative stress parameters in preeclampsia.

Background And Aims: Preeclampsia (PE) is a serious medical condition that usually causes high blood pressure and affects multiple organs. Considering the adverse effect of oxidative stress on the process of PE in pregnant women and regarding the role of the Nrf2 gene in placental oxidative pathways, this study was conducted to investigate the DNA methylation status of Nrf2 in PE and healthy pregnant women.

Materials And Methods: The present case-control study consisted of 70 PE and 70 healthy pregnant women.

The study of DNA methylation and gene expression and the diagnostic potential of in preeclampsia.

The objective was to elucidate the potential epigenetic regulatory mechanism in  expression in preeclampsia. promoter DNA methylation was evaluated in the placental tissue and blood of preeclamptic and normotensive pregnant women. and gene expression were assessed in placental tissue and peripheral blood mononuclear cells (PBMCs).

Evaluation of the association between TNF-α-1031 T/C polymorphism with oral lichen planus disease.

Background: Oral lichen planus (OLP) is a T-cell-mediated autoimmune disease that affects the epithelial cells of the oral cavity. This study was performed to investigate any possible relationship between - 1031(T/C) polymorphism (rs1799964) of the tumor necrosis factor α (TNF-α) gene with the risk and severity of oral lichen planus (OLP) disease among an Iranian population.

Method: Saliva samples were collected from 100 patients with OLP and a similar number of healthy controls (age and sex-matched).

Impact of DNA methylation of the human mesoderm-specific transcript () on male infertility.

Male infertility accounts for nearly 40%-50% of all infertile cases. One of the most prevalent disorders detected in infertile men is errors in the MEST differentially methylated region (DMR), which has been correlated with poor sperm indexes. The aim of our study was to characterize the methylation pattern of the MEST gene, along with assessing seminal factors and chromatin condensation in sperm samples from both infertile patients and fertile cases, all of whom were candidates for intracytoplasmic sperm injection.

Characterization of CAR T Cells Manufactured Using Genetically Engineered Artificial Antigen Presenting Cells.

Objective: Chimeric antigen receptor (CAR) T cell therapy has recently emerged as a promising approach for the treatment of different types of cancer. Improving CAR T cell manufacturing in terms of costs and product quality is an important concern for expanding the accessibility of this therapy. One proposed strategy for improving T cell expansion is to use genetically engineered artificial antigen presenting cells (aAPC) expressing a membrane-bound anti-CD3 for T cell activation.

The Association of PTEN Gene Mutations with the Breast Cancer Risk: A Systematic Review and Meta-analysis.

Breast cancer (BC) is the most common malignancy in women in western countries. A significant part of malignant cases is caused by genetic mutation. Mutations in the gene phosphatase and tensin homologue deleted on chromosome (PTEN) have been proven in various malignancies.

Association of interleukin-8 polymorphism (+ 781 C/T) with the risk of oral Lichen Planus disease.

Background: Oral Lichen Planus (OLP) is a chronic inflammatory mucosal disease. The pathogenesis of OLP is unknown. The Single Nucleotide Polymorphism (SNP) that occurs in the regulatory position + 781 could affect the expression of interleukin-8.

Evaluating effect of salt leaching method on release and swelling rate of metformin nanoparticles loaded-chitosan/polyvinyl alcohol porous composite.

In this study, salt leaching (SL) technique was used to prepare a chitosan/polyvinyl alcohol (CS/PVA) polymeric composite in order to load metformin nanoparticles (METNPs). Sodium chloride was added to the CS/PVA (0.5:0.

Role of Polymorphisms on the Recurrent Pregnancy Loss: A Systematic Review, Meta-analysis and Bioinformatic Analysis.

Recurrent miscarriage (RM) is a major reproductive health issue. RM is a multi-factorial disease, and is affected by environmental, genetic, and epigenetic factors. Genetics has a common role in recurrent miscarriage occurrence.

MiR-1290: a potential therapeutic target for regenerative medicine or diagnosis and treatment of non-malignant diseases.

MicroRNAs are a set of small non-coding RNAs that could change gene expression with post-transcriptional regulation. MiRNAs have a significant role in regulating molecular signaling pathways and innate and adaptive immune system activity. Moreover, miRNAs can be utilized as a powerful instrument for tissue engineers and regenerative medicine by altering the expression of genes and growth factors.

Concurrent Breast Carcinoma and Follicular Lymphoma: A Case Series.

BACKGROUND The incidence of multiple primaries in cancer patients is 2-17%. However, the synchronous co-occurrence of adenocarcinoma of the breast and follicular lymphoma is rare. CASE REPORT We describe a case series of 3 post-menopausal women who presented to our institute with a breast lump.

Association of Vitamin D Receptor Polymorphisms ( (Rs2228570), (Rs7975232), (Rs1544410), and (Rs731236)) with Gastric Cancer in a Kurdish Population from West of Iran.

Background: The association of 1,25-dihydroxy vitamin D3 (1,25(OH)2D3) and its receptor, vitamin D receptor (VDR), with cancer types have been studied. However, there are controversial findings regarding the association of specific VDR polymorphisms with different kinds of cancers. In the current study, we investigated the association of VDR polymorphisms (Fok1 (rs2228570), (rs7975232), (rs1544410), and (rs731236)) with the risk of gastric cancer in a Kurdish population of Kermanshah in Iran for the first time.

Variants of Genes Involved in Metabolism of Folate Among Patients with Breast Cancer: Association of 3R Allele with Susceptibility to Breast Cancer and Metastasis.

Background & Objective: Breast cancer (BC) is known to be the most prevalent cancer among women. One-carbon metabolism disturbance might play an important role in the etiology of BC. The present study aimed to investigate the thymidylate synthase (TYMS), 5-methyltetrahydrofolate-homocysteine methyltransferase (MTR), and methionine synthase reductase (MTRR) variants as good candidates for studying the role of genetic variants of folate metabolizing enzymes in the risk of BC.

A case-control study on the SNP309T → G and 40-bp Del1518 of the MDM2 gene and a systematic review for MDM2 polymorphisms in the patients with breast cancer.

Objective: The current research was conducted to study the association between the SNP309 and del1518 polymorphisms with the breast cancer in the patients with the Kurdish ethnic background from western Iran. Also, a systematic review of the relevant case-control studies on the MDM2 polymorphisms in the patients with breast cancer was performed.

Methodology: Two mL of peripheral blood was taken from 100 patients with breast cancer and 100 healthy individuals.

The acute and chronic effects of resistance training with blood flow restriction on hormonal responses in untrained young men: A comparison of frequency.

The present study aimed to determine the effect of low-intensity training with blood flow restriction (BFR) on the response rate of anabolic hormones. Forty healthy and untrained young men, aged 18 to 25 years old, were randomly divided into five groups: one session of BFR training (BFR1), two sessions of BFR training (BFR2), one session of resistance training without BFR (WBFR1), two sessions of resistance training without BFR (WBFR2), and the control group (without training). BFR groups had three sets of 20 repetitions with 20-30% 1RM, and none-BFR groups had three sets of 10 repetitions with 70-80% 1RM for six weeks.

Development and evaluation of sodium alginate-basil seeds mucilage beads as a suitable carrier for controlled release of metformin.

Sodium alginate (SA) is a natural biopolymer that is used as biodegradable and non-toxic material in medical and pharmaceutical fields. Although crosslinked SA with calcium ions in the presence of monovalent salts are unstable. The aim of this work is to employe plant mucilage in combination of SA beads to improve the properties of SA beads.

Promoter Methylation Status of the Retinoic Acid Receptor-Beta 2 Gene in Breast Cancer Patients: A Case Control Study and Systematic Review.

Background: We aimed to determine the promoter methylation status of the retinoic acid receptor-beta 2 gene among breast cancer patients and to review relevant studies in this field in various populations.

Methods: We analyzed 400 samples which comprised blood specimens from 102 breast cancer patients, 102 first-degree female relatives of patients, 100 cancer-free females, 48 breast cancer tissues, and 48 adjacent normal breast tissues from the same patients. The methylation status was determined using methylation-specific polymerase chain reaction (MSP) and DNA sequencing methods.

A comparative study for the removal of imidacloprid insecticide from water by chemical-less UVC, UVC/TiO and UVC/ZnO processes.

Background: Chloronicotinic insecticide are a class of pesticides that are commonly used as insecticides. Among the frequently used chloronicotinic pesticide, imidacloprid (IM) was developed in 1986. The residual of this insecticide or any pesticides may have serious public health threats.

Comment on: 'A 40-bp insertion/deletion polymorphism in the constitutive promoter of MDM2 confers risk for hepatocellular carcinoma in a Chinese population'.

Recently, we read the published article in GENE. Dong et al. presented the evaluation of the MDM2 40-bp insertion/deletion status in Hepatocellular carcinoma patients (Dong et al.