Publications by authors named "Yared Yohannes Melcamu"
Article Synopsis
- Enantiopure vicinal amino alcohols are important for natural products and drugs, but current methods for their synthesis are limited in effectiveness.
- This research introduces a new dual catalytic approach that uses a radical mechanism and special chiral ligands to improve enantioselectivity and reaction conditions.
- The new method is easy to perform, works under mild conditions, produces high yields, and has been used to synthesize valuable pharmaceuticals like ephedrine and selegiline.
We have developed a unified strategy for preparing a variety of imidazo-fused N-heteroaromatic compounds through regiospecific electrochemical (3+2) annulation reaction of heteroarylamines with tethered internal alkynes. The electrosynthesis employs a novel tetraarylhydrazine as the catalyst, has a broad substrate scope, and obviates the need for transition-metal catalysts and oxidizing reagents.
View Article and Find Full Text PDFIndoles and azaindoles are among the most important heterocycles because of their prevalence in nature and their broad utility in pharmaceutical industry. Reported herein is an unprecedented noble-metal- and oxidant-free electrochemical method for the coupling of (hetero)arylamines with tethered alkynes to synthesize highly functionalized indoles, as well as the more challenging azaindoles.
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