Publications by authors named "Yarden Ziv"
Cocaine use disorder (CUD) is a chronic neuropsychiatric disorder estimated to effect 1-3% of the population. Activity-dependent neuroprotective protein (ADNP) is essential for brain development and functioning, shown to be protective in fetal alcohol syndrome and to regulate alcohol consumption in adult mice. The goal of this study was to characterize the role of ADNP, and its active peptide NAP (NAPVSIPQ), which is also known as davunetide (investigational drug) in mediating cocaine-induced neuroadaptations.
View Article and Find Full Text PDFActivity-dependent neuroprotective protein (ADNP), discovered and first characterized in our laboratory (IG), is vital for mammalian brain formation and presents one of the leading genes mutated de novo causing an autistic syndrome, namely the ADNP syndrome. Furthermore, a unique mouse model of Adnp-haploinsufficiency was developed in the laboratory (IG), with mice exhibiting cognitive and social deficiencies. ADNP is regulated by vasoactive intestinal peptide (VIP), and pituitary adenylate cyclase-activating peptide (PACAP).
View Article and Find Full Text PDFArticle Synopsis
- - Excessive alcohol intake causes changes in the brain's reward system, leading to increased drinking and potentially alcohol use disorder, with the activity-dependent neuroprotective protein (ADNP) playing a role in moderating these effects in a sex-dependent manner.
- - Short-term and long-term alcohol exposure was found to increase Adnp mRNA levels in specific brain areas, but the effects varied by sex: males showed temporary increases whereas females had a long-term decrease in Adnp levels.
- - In experiments with mice, female mice lacking ADNP showed higher alcohol consumption, but treatment with an ADNP-based drug normalized their drinking, indicating that ADNP could serve as a new marker and regulator of drinking behaviors, particularly in females.