It takes two to empathize: Interbrain coupling contributes to distress regulation.

While extant research on empathy has made significant progress in uncovering the mechanisms underlying the responses of an observer (empathizer) to the distress of another (target), it remains unclear how the interaction between the empathizer and the target contributes to distress regulation in the target. Here, we propose that behavioral and neural coupling during empathic interactions contribute to diminished distress. From November 2020 to November 2022, we recruited 37 pairs of previously unacquainted participants ( = 74) from multicultural backgrounds.

Diverse serotonin actions of vilazodone reduce l-3,4-dihidroxyphenylalanine-induced dyskinesia in hemi-parkinsonian rats.

Background: The serotonergic system is a well-established modulator of l-dopa-induced dyskinesia. To date, targeting serotonin transporters or serotonin receptor subtype 1A (5-HT ) reduces l-dopa-induced dyskinesia in animal models; however, these strategies have failed to translate clinically. Ideally, a compound acting at both known antidyskinetic sites could optimize serotonin-mediated approaches.