Publications by authors named "Yara Khalaila"
Article Synopsis
- SARS-CoV-2 variants Kappa and Delta have quickly become dominant worldwide, but their infectivity and vaccine response were previously unclear.
- Research shows that both variants can be neutralized by convalescent sera and post-vaccination sera, although there is some reduction in sensitivity compared to earlier strains.
- Delta variant demonstrates higher infectivity than Kappa but is still less resistant to vaccines than the Beta variant, while the Delta plus variant shows high resistance similar to Beta, despite having infectivity levels akin to wild-type SARS-CoV-2.
Toward eradicating the COVID-19 pandemic, vaccines that induce high humoral and cellular immune responses are essential. However, SARS-CoV-2 variants have begun to emerge and raise concerns, as they may potentially compromise vaccine efficiency. Here, we monitored neutralization potency of convalescent or Pfizer-BTN162b2 post-vaccination sera against pseudoviruses displaying spike proteins derived from wild-type SARS-CoV-2, or its UK-B.
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