Publications by authors named "Yara Basler"
Article Synopsis
- Activin and BMP signaling are essential for organ formation, tissue maintenance, and require careful regulation to prevent issues like inflammation and abnormal bone growth.
- A specific mutation in the BMP receptor in humans (R206H on hsACVR1) results in excessive SMAD phosphorylation, leading to FOP, a condition characterized by abnormal bone development.
- Researchers have explored using the Japanese medaka fish as a model for studying FOP, confirming that it expresses relevant receptors and shows similar elevated SMAD signaling when carrying the FOP mutation, laying the groundwork for further investigation into the disease.
