Publications by authors named "Yaqiu Chen"
RNA silencing, a conserved gene regulatory mechanism, is critical for host resistance to viruses. Liquid-liquid phase separation (LLPS) is an important mechanism in regulating various biological processes. Emerging studies suggest RNA helicases play important roles in microRNA (miRNA) production through LLPS.
View Article and Find Full Text PDFSeed germination is an important phase transitional period of angiosperm plants during which seeds are highly sensitive to different environmental conditions. Although seed germination is under the regulation of salicylic acid (SA) and other hormones, the molecular mechanism underlying these regulations remains mysterious. In this study, we determined the expression of SA methyl esterase () family genes during seed germination.
View Article and Find Full Text PDFArticle Synopsis
- Genetic factors play a major role in nonsyndromic hearing loss, particularly in families with multiple deaf children, indicating a significant hereditary component.
- This study focused on four Chinese families who had two nonsyndromic deaf children but did not have identifiable genetic causes from standard testing methods.
- Through advanced next-generation sequencing of 127 known deafness-related genes, the researchers discovered specific pathogenic variants in three families and provided new insights into the genetic causes of hearing loss in similar cases.
[Current status of newborn deafness gene screeningin parts of China].
Lin Chuang Er Bi Yan Hou Tou Jing Wai Ke Za Zhi
November 2020
Article Synopsis
- - The study analyzed newborn deafness gene screening in China from 2016 to 2017 across 41 institutions, assessing the status, methods, and positive detection rates.
- - Out of the institutions, 15 (36.59%) conducted gene screening, with the highest prevalence in eastern China (72.22%).
- - Among 340,521 neonates screened, there was a positive detection rate of 5.00%, with various mutation rates reported for specific genes.
Current status of universal newborn hearing screening program at 26 institutions in China.
Int J Pediatr Otorhinolaryngol
November 2020
Article Synopsis
- The study assessed the effectiveness of a universal newborn hearing screening (UNHS) program in China by comparing data from 2016 and 2017 across different regions.
- Results showed improvements in initial screening coverage and rescreening rates in 2017, with a decrease in referral rates compared to 2016.
- The majority of institutions employed a combination of otoacoustic emissions (OAE) and automated auditory brainstem response (AABR) tests for screenings, and over half had a digital information management system for UNHS.
Small RNA (sRNA) turnover is a key but poorly understood mechanism that determines the homeostasis of sRNAs. Animal XRN genes contribute the degradation of sRNAs, AtXRN2 and AtXRN3 also contribute the pri-miRNA processing and miRNA loop degradation in plants. However, the possible functions of the plant XRN genes in sRNA degradation are far from known.
View Article and Find Full Text PDFThe aim of this study was to investigate the mechanism by which growth arrest-specific transcript 5 (GAS5) regulates bladder cancer cells. Bladder cancer samples were collected and tested for experiment. Dual-luciferase reporter assay was used to verify the downstream target genes for GAS5 and miR-21.
View Article and Find Full Text PDFWith the wide usage of electronic packaging technologies such as Ball Grid Array in electronic industry, it is necessary to maintain its quality in order to meet the demand of electronic products for function, integration, and size reduction. However, as the size of solder joints in such technology decreases, the solder joints are more and more prone to defects. To solve the life prediction problem of small-size packages having interconnections in the high-density chip, a method based on the eddy current pulsed thermography (ECPT) is put forward to study the remaining life prediction of solder joints.
View Article and Find Full Text PDFPurpose: The benefits of concurrent newborn hearing and genetic screening have not been statistically proven due to limited sample sizes and outcome data. To fill this gap, we analyzed outcomes of newborns with genetic screening results.
Methods: Newborns in China were screened for 20 hearing-loss-related genetic variants from 2012 to 2017.
Detection of small-size solder ball defects through heat conduction analysis.
Rev Sci Instrum
February 2018
Article Synopsis
- The study focuses on using heat conduction analysis through eddy current pulsed thermography to detect small-size solder ball defects in high-density chips.
- A 3D finite element model helps in identifying defects like cracks and voids by observing temperature differences caused by heat conduction.
- Experiments with various solder ball defects confirm the effectiveness of this method, showing it can reliably distinguish small defects, such as cracks of varying lengths on gull-wing pins.
Newborn hearing concurrent genetic screening for hearing impairment-a clinical practice in 58,397 neonates in Tianjin, China.
Int J Pediatr Otorhinolaryngol
December 2013
Objective: Newborn hearing screening (NHS) is used worldwide due to its feasibility and cost-efficiency. However, neonates with late-onset and progressive hearing impairment will be missed by NHS. Genetic factors account for an estimated 60% of congenital profound hearing loss.
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- The paper introduces a new method called combinative neural network (CN) that uses partial least squares (PLS) analysis to enhance the hidden layer in multi-layered feed forward neural networks (NN).
- This approach reorganizes the outputs of hidden nodes to effectively address the correlation of variables, optimize non-linear relationships between input and output data, and reduce the risk of overfitting.
- The proposed CN method demonstrated strong performance in two case studies—a nonlinear approximation problem and a nonlinear pattern classification challenge—showing advantages over conventional multi-layered feed forward neural networks in both effectiveness and efficiency.
[Clinical study on applying brainstem auditory evoked potential to monitor anesthesia depth and awaken in children].
Zhonghua Er Bi Yan Hou Ke Za Zhi
April 2003
Article Synopsis
- The study aims to evaluate how auditory brainstem responses (ABR) can be used to objectively monitor anesthesia depth and awakening in children.
- It involved 45 children receiving different types of anesthesia (propofol, fentanyl, or isoflurane) and measured the latencies of ABR waves in response to sound stimulation.
- The results indicated that the latencies are positively correlated with anesthesia dosage and can help assess the degree of anesthesia, although fentanyl showed less sensitivity in monitoring.