Association between periodontitis and inflammatory comorbidities: The common role of innate immune cells, underlying mechanisms and therapeutic targets.

Periodontitis, which is related to various systemic diseases, is a chronic inflammatory disease caused by periodontal dysbiosis of the microbiota. Multiple factors can influence the interaction of periodontitis and associated inflammatory disorders, among which host immunity is an important contributor to this interaction. Innate immunity can be activated aberrantly because of the systemic inflammation induced by periodontitis.

Regulatory role of RBM39 in acute myeloid leukemia: Mediation through the PI3K/AKT pathway.

Background: Acute myeloid leukemia (AML) presents ongoing therapeutic challenges due to its intricate molecular pathogenesis. This study aimed to elucidate the role of RNA binding motif protein 39 (RBM39) in AML cell proliferation, apoptosis, and chemosensitivity, and its potential modulation of the PI3K/AKT pathway.

Methods: In vitro and in vivo experiments were conducted using AML cell lines (K562 and U937) and bone marrow mononuclear cells (BM-MNCs) from AML patients and healthy donors.

Predictive value of ACEF II score for adverse prognosis in patients with coronary heart disease after percutaneous coronary intervention.

Objective: To investigate the predictive value of age, creatinine and ejection fraction (ACEF) II score for the incidence of major adverse cardiovascular and cerebrovascular events (MACCEs) in patients with coronary heart disease (CHD) after percutaneous coronary intervention (PCI).

Methods: A total of 445 patients with CHD who underwent PCI were consecutively enrolled. The receiver operating characteristic (ROC) curve was used to analyse the power of the ACEF II score in predicting MACCE.

The epigenetic regulatory mechanism of PIWI/piRNAs in human cancers.

PIWI proteins have a strong correlation with PIWI-interacting RNAs (piRNAs), which are significant in development and reproduction of organisms. Recently, emerging evidences have indicated that apart from the reproductive function, PIWI/piRNAs with abnormal expression, also involve greatly in varieties of human cancers. Moreover, human PIWI proteins are usually expressed only in germ cells and hardly in somatic cells, so the abnormal expression of PIWI proteins in different types of cancer offer a promising opportunity for precision medicine.

Pyroptosis and Its Regulation in Diabetic Cardiomyopathy.

Diabetic cardiomyopathy (DbCM) is a prevalent disease, characterized by contractile dysfunction and left ventricular hypertrophy. Patients with DbCM have high morbidity and mortality worldwide. Recent studies have identified that pyroptosis, a kind of cell death, could be induced by hyperglycemia involved in the formation of DbCM.

Drivers of 2013-2020 ozone trends in the Sichuan Basin, China: Impacts of meteorology and precursor emission changes.

The Sichuan Basin (SCB) of China is known for excessive ozone (O) pollution owing to high anthropogenic emissions combined with terrain-induced poor ventilation and weak wind fields against the surrounding mountains. While O pollution has emerged as a prominent concern in southwestern China yet variations in O levels during 2013-2020 are still unclear and the dominant factor in explaining the long-term O trend throughout the SCB remains elusive due to uncertainties in emission inventory and variability associated with meteorological conditions. Here, we use extensive basin-wide ambient measurements to examine the spatial pattern and trend of O and leverage OMI and TROPOMI satellites in conjunction with MEIC emission inventory to track emission changes.

HNRNPH1 Is a Novel Regulator Of Cellular Proliferation and Disease Progression in Chronic Myeloid Leukemia.

RNA binding proteins act as essential modulators in cancers by regulating biological cellular processes. Heterogeneous nuclear ribonucleoprotein H1 (HNRNPH1), as a key member of the heterogeneous nuclear ribonucleoproteins family, is frequently upregulated in multiple cancer cells and involved in tumorigenesis. However, the function of HNRNPH1 in chronic myeloid leukemia (CML) remains unclear.

Origin of regional springtime ozone episodes in the Sichuan Basin, China: Role of synoptic forcing and regional transport.

The Sichuan Basin (SCB) located in southwestern China has long been considered the most polluted city cluster with exposure to unhealthy levels of ozone (O) at times. However, the features of O regional transport and source contributions in SCB are poorly understood. In this study, ambient measurements, ERA5 reanalysis dataset, IASI O column, and the Weather Research and Forecasting-Community Multiscale Air Quality (WRF-CMAQ) modeling system coupled with the Integrated Source Apportionment Method (ISAM) module were used to investigate the formation mechanism and sources of a severe O episode in spring 2020 over the SCB.

Biological characteristics of exosomes and genetically engineered exosomes for the targeted delivery of therapeutic agents.

A primary focus of pharmacology is the accurate transport of drugs from the peripheral veins and their delivery to specific tissues and organs. Exosomes are nanoscale extracellular vesicles with comparatively enhanced circulation stability, biocompatibility, physicochemical stability and bio-barrier permeation ability, as well as reduced toxicity. Therefore, they are considered a superior drug delivery platform.

miR-140-5p induces cell apoptosis and decreases Warburg effect in chronic myeloid leukemia by targeting SIX1.

microRNAs (miRNA), as tumor suppressors or oncogenes, are involved in modulating cancer cell behavior, including cell proliferation and apoptosis. The miR-140-5p acts as a tumor suppressor in several tumors, but the role of miR-140-5p in chronic myeloid leukemia (CML) remains unclear. Here, we investigated the suppression of miR-140-5p in CML patients and CML cell lines using quantitative PCR (qPCR) and fluorescence hybridization (FISH).

Activin A increases arterial pressure in the hypothalamic paraventricular nucleus in rats by angiotension II.

Activin A, a member of the transforming growth factor β superfamily, plays an important role in the central nervous system as a neurotrophic and neuroprotective factor. The hypothalamic paraventricular nucleus (PVN) in the central nervous system is characterized as an important integrative site to regulate arterial pressure (AP). However, whether activin A in the PVN is involved in the regulation of AP is not well characterized.

Particulate air pollution in Lanzhou China.

Concentrations of total suspended particles (TSP) and PM(10) in Lanzhou China have been kept high for the past two decades. Data collected during the intensive observational period from October 1999 to April 2001 show high TSP and PM(10) concentrations. Starting from November, the PM(10) pollution intensifies, and reaches mid to high alert level of air pollution, continues until April next year, and is at low alert level in the summer.