Designing a Novel Ultrashort Cyclic [RWV] Antimicrobial Peptide with Superior Antimicrobial Potential Based on the Transmembrane Structure to Facilitate Pore Formation.

The clinical application of antimicrobial peptides (AMPs) is frequently hindered by the inherent limitations of linear peptides. Previous studies have primarily focused on the physicochemical properties of AMPs, and there is a scarcity of information regarding the transmembrane structure and interactions of AMPs with cell membranes and their antimicrobial activity. The present study is the first to propose that the backbone cyclization of linear RWV (l(RWV)) into the cyclic RWV (c[RWV]) form can enhance the stability of its transmembrane structure and consequently improve its antibacterial activity.

Assessment of Knowledge, Attitude, and Practice Toward COVID-19 in China: An Online Cross-Sectional Survey.

To analyze the level of knowledge, attitude, and practice about COVID-19 among Chinese residents, noninterventional and anonymous survey was carried out with an online questionnaire. Among the survey respondents (n = 619), 59.9% were female, 61.

Large-scale national screening for Coronavirus Disease 2019 in China.

Faced with the new challenges in the pandemic control, imported coronavirus disease (COVID-19) infections and asymptomatic infection, Chinese authorities have implemented new intervention measures-national large-scale nucleic acid testing. This article summarizes the population who needs the nucleic acid testing, analyzes the current data of COVID-19 testing capacity, concludes the timeline of coronavirus testing and suggests what needs to be done to facilitate the government large-scale screening measures.

Transmission dynamics of the COVID-19 outbreak and effectiveness of government interventions: A data-driven analysis.

Using the parameterized susceptible-exposed-infectious-recovered model, we simulated the spread dynamics of coronavirus disease 2019 (COVID-19) outbreak and impact of different control measures, conducted the sensitivity analysis to identify the key factor, plotted the trend curve of effective reproductive number (R), and performed data fitting after the simulation. By simulation and data fitting, the model showed the peak existing confirmed cases of 59 769 arriving on 15 February 2020, with the coefficient of determination close to 1 and the fitting bias 3.02%, suggesting high precision of the data-fitting results.