An integrative analysis of ASCL1 in breast cancer and inhibition of ASCL1 increases paclitaxel sensitivity by activating ferroptosis via the CREB1/GPX4 axis.

Objective: Our previous study found that Achaete-scute complex homolog 1 (ASCL1) is involved in classifying BC subtypes with different prognostic and pathological characteristics. However, the biological role of ASCL1 in BC still remains largely unexplored. This study aims to elucidate the function of ASCL1 in BC using bioinformatics analyses, as well as and experimental approaches.

Degradation of dioxins in chelated municipal solid waste incineration fly ash by low-temperature pyrolysis.

In this study, low-temperature pyrolysis is applied to raw and chelated municipal solid waste incinerator fly ash to degrade and remove PCDD/F (polychlorinated dibenzo-p-dioxins, and dibenzofurans) and corresponding I-TEQs (international toxic equivalents), respectively. Additionally, PCDD/F degradation pathways are identified based on PCDD/F signatures. From the analysis of the average signal intensity of dioxin isomers in thermally treated fly ashes, the PCDD/F degradation rate was between 89.

Correction: Characterization of two constitutive promoters and for studying soybean growth, development, and symbiotic nodule development.

[This corrects the article DOI: 10.1007/s42994-022-00073-6.].

[Effect of endoscopic surgery combined with chemotherapy and radiotherapy on prognosis of early nasopharyngeal carcinoma patients in high incidence area].

To investigate the differences in the therapeutic effects of endoscopic surgery combined with chemotherapy and endoscopic surgery combined with radiotherapy in the treatment of early nasopharyngeal carcinoma, and to select individualized treatment strategy for early nasopharyngeal carcinoma. The clinical data of 68 patients with early nasopharyngeal carcinoma（T1-2N₀M₀） who received surgical treatment in a high-incidence area were retrospectively analyzed. According to different treatment methods, they were divided into the surgery + chemotherapy group（=34, treated with endoscopic surgery combined with chemotherapy） and the surgery + radiotherapy group（=34, treated with endoscopic surgery combined with radiotherapy）.

Nitrogen deficiency modulates carbon allocation to promote nodule nitrogen fixation capacity in soybean.

Previously, the effect of soil mineral N deficiency on nodule nitrogen fixation capacity (NFC) is unclear. In this study, we found that N deficiency would enhance sucrose allocation to nodules and PEP allocation to bacteroid to promote nodule NFC. Our findings provide new insights into the design of leguminous crops with improved adaptation to fluctuating N levels in the soil.

Biomarkers and Tourette syndrome: a systematic review and meta-analysis.

Objective: This research aims to investigate whether peripheral biomarkers might differentiate individuals with Tourette syndrome (TS) from those without the condition.

Methods: A broad range of databases was searched through November 2022. This study employed a systematic literature review and subsequent meta-analysis of case-control studies that assessed the aberration of biomarkers of patients with TS and controls.

New mechanistic insight into catalytic decomposition of dioxins over MnO-CeO/TiO catalysts: A combined experimental and density functional theory study.

Elucidation of the catalytic decomposition mechanism of dioxins is pivotal in developing highly efficient dioxin degradation catalysts. In order to accurately simulate the whole molecular structure of dioxins, two model compounds, o-dichlorobenzene (o-DCB) and furan, were employed to represent the chlorinated benzene ring and oxygenated central ring within a dioxin molecule, respectively. Experiments and Density Functional Theory (DFT) calculations were combined to investigate the adsorption as well as oxidation of o-DCB and furan over MnO-CeO/TiO catalyst (denoted as MnCe/Ti).

Soluble humic acid suppresses plant immunity and ethylene to promote soybean nodulation.

Symbiotic nitrogen fixation (SNF) is a crucial process for nitrogen geochemical cycling and plant-microbe interactions. Water-soluble humic acid (WSHM), an active component of soil humus, has been shown to promote SNF in the legume-rhizobial symbiosis, but its molecular mechanism remains largely unknown. To reveal the SNF-promoting mechanism, we conducted transcriptomic analysis on soybean treated with WSHM.

Synthesis of layered double hydroxides from municipal solid waste incineration fly ash for heavy metal adsorption.

The process of urbanization has resulted in a continuous growth of the production of municipal solid waste, consequently leading to the increase of municipal solid waste incineration fly ash (MSWI FA) over time. This has prompted the need for effective disposal and value-added utilization strategies for MSWI FA. In this study, a hydrothermal method was employed to synthesize CaAl layered double hydroxides (LDHs) using MSWI FA as the raw material.

Use of municipal solid waste incineration fly ash as a supplementary cementitious material: CO mineralization coupled with mechanochemical pretreatment.

The use of municipal solid waste incineration fly ash, commonly referred to as "fly ash", as a supplementary cementitious material (SCM), has been explored to mitigate the CO emissions resulting from cement production. Nevertheless, the incorporation of fly ash as an SCM in mortar has been shown to weaken its compressive strength and increase the risk of heavy metal leaching. In light of these challenges, this study aims to comprehensively evaluate the influence of CO pressure, temperature, and residual water/binder ratio on the CO uptake and compressive strength of mortar when combined with fly ash.

Mesenchymal stromal cells and their small extracellular vesicles in allergic diseases: From immunomodulation to therapy.

Mesenchymal stromal cells (MSCs) have long been considered a potential tool for treatment of allergic inflammatory diseases, owing to their immunomodulatory characteristics. In recent decades, the medical utility of MSCs has been evaluated both in vitro and in vivo, providing a foundation for therapeutic applications. However, the existing limitations of MSC therapy indicate the necessity for novel therapies.

Insight into the formation of polychlorinated dibenzo-p-dioxins and dibenzofurans in hazardous waste incineration and incinerators: Formation process and reduction strategy.

Incineration technology has been widely adopted to safely dispose of hazardous waste (HW). While the incineration process causes the formation of polychlorinated dibenzo-p-dioxins and dibenzofurans (PCDD/Fs). Due to its extreme toxicity, many scholars have been committed to determining the PCDD/F formation process and reducing emissions in incinerators.

Dendritic cells mediated by small extracellular vesicles derived from MSCs attenuated the ILC2 activity via PGE2 in patients with allergic rhinitis.

Background: Mesenchymal stromal cells-derived small extracellular vesicles (MSC-sEVs) have recently attracted considerable attention because of their therapeutic potential in various immune diseases. We previously reported that MSC-sEVs could exert immunomodulatory roles in allergic airway inflammation by regulating group 2 innate lymphoid cell (ILC2) and dendritic cell (DC) functions. Therefore, this study aimed to investigate the indirect effects of MSC-sEVs on ILC2s from patients with allergic rhinitis (AR) via DCs.

Interaction of High Temperature Stress and Infection on the Biological Characteristic of .

It was reported that temperature affects the distribution of in the host, but only a few papers reported the effect of the interaction between high temperature and on the biological characteristic of the host. Here, we set four treatment groups: -infected flies in 25 °C (WM), -infected flies in 31 °C (WH), -uninfected flies in 25 °C (WM), -uninfected flies in 31 °C (WH), and detected the interaction effect of temperature and infection on the biological characteristic of in F, F and F generations. We found that both temperature and infection had significant effects on the development and survival rate of .

GmBES1-1 dampens the activity of GmNSP1/2 to mediate brassinosteroid inhibition of nodulation in soybean.

Soybean (Glycine max) forms root nodules to house rhizobial bacteria for biological nitrogen fixation. The development of root nodules is intricately regulated by endogenous and exogenous cues. The phytohormones brassinosteroids (BRs) have been shown to negatively regulate nodulation in soybean, but the underlying genetic and molecular mechanisms remain largely unknown.

Communal rearing induces high predatory capacity in a solitary wolf spider and its potential in pest control.

Behavioral plasticity is of great significance because it allows individuals to flexibly respond to variations in the ecological and social environment. To date, there is little published data on the topic of whether the early rearing experience of spiders influences their later foraging behavior. (Araneae: Lycosidae) is a solitary wolf spider, it is a major predator of pests such as in rice fields.

Gut epithelial barrier damage caused by dishwasher detergents and rinse aids.

Background: The increased prevalence of many chronic inflammatory diseases linked to gut epithelial barrier leakiness has prompted us to investigate the role of extensive use of dishwasher detergents, among other factors.

Objective: We sought to investigate the effects of professional and household dishwashers, and rinse agents, on cytotoxicity, barrier function, transcriptome, and protein expression in gastrointestinal epithelial cells.

Methods: Enterocytic liquid-liquid interfaces were established on permeable supports, and direct cellular cytotoxicity, transepithelial electrical resistance, paracellular flux, immunofluorescence staining, RNA-sequencing transcriptome, and targeted proteomics were performed.

Phosphoenolpyruvate reallocation links nitrogen fixation rates to root nodule energy state.

Legume-rhizobium symbiosis in root nodules fixes nitrogen to satisfy the plant's nitrogen demands. The nodules' demand for energy is thought to determine nitrogen fixation rates. How this energy state is sensed to modulate nitrogen fixation is unknown.

Characterization of two constitutive promoters and for studying soybean growth, development, and symbiotic nodule development.

Unlabelled: Native promoters that can drive high and stable transgene expression are important tools for modifying plant traits. Although several such promoters have been reported in soybean (), few of them function at multiple growth and development stages and during nodule development. Here, we report that the promoters of () and () are ideal for high expression of transgene.

Inhibition of PCDD/Fs in a full-scale hazardous waste incinerator by the quench tower coupled with inhibitors injection.

The control of polychlorinated dibenzo-p-dioxins and dibenzofurans (PCDD/Fs) from the flue gas in hazardous waste incinerators (HWIs) is an intractable problem. To figure out the formation mechanism of PCDD/Fs and reduce the emission, a field study was carried out in a full-scale HWI. Ca(OH) & (NH)HPO or CHNS & (NH)HPO were injected into the quench tower, and the detailed inhibition effect on PCDD/Fs formation by the inhibitors coupled with quench tower was studied.

Full-Length Transcriptome Sequencing Reveals Alternative Splicing and lncRNA Regulation during Nodule Development in .

Alternative splicing (AS) is a ubiquitous phenomenon among eukaryotic intron-containing genes, which greatly contributes to transcriptome and proteome diversity. Here we performed the isoform sequencing (Iso-Seq) of soybean underground tissues inoculated and uninoculated with Rhizobium and obtained 200,681 full-length transcripts covering 26,183 gene loci. It was found that 80.