Comparative study of different pretreatment methods on peanut oil quality characteristics, anti-oxidation attributes, and phenolic compound compositions.

The peanuts heat pretreatment is a crucial step for the following oil extraction, influencing both efficiency and oil quality. The present study investigated the effects of oven roasting (OR, 150 °C, 25 min), infrared ray roasting (IRR, 150 °C, 25 min), and microwave roasting (MR, 700 W, 5 min) on the quality characteristics, anti-oxidation attributes, and phenolic compound compositions of peanut oil. All pretreatment methods changed the physicochemical properties and bioactive compounds of peanut oil.

Biochanin A Attenuates Psoriasiform Inflammation by Regulating Nrf2/HO-1 Pathway Activation and Attenuating Inflammatory Signalling.

Psoriasis is a long-term inflammatory skin condition marked by an overabundance of keratinocytes and the release of pro-inflammatory cytokines in the outer layer of skin. For the comprehensive management of intermediate to advanced psoriasis, innovative biological treatments have been developed. Products for the superficial therapy of mild to moderate psoriasis are still necessary, though.

Comparison of dual-energy computed tomography (DECT) polychromatic and monochromatic images with and without iterative metal artifact reduction algorithm in patients with dental implants.

Background: Dual-energy computed tomography (DECT) and iterative metal artifact reduction (iMAR) algorithms are valuable tools for reducing metal artifacts. Different parameters of these technologies and their combination can achieve different performance. This study compared various polychromatic and monochromatic images obtained via DECT with and without using iMAR algorithm to reduce artifacts in patients with dental implants.

Radiomics analysis of pancreas based on dual-energy computed tomography for the detection of type 2 diabetes mellitus.

Objective: To utilize radiomics analysis on dual-energy CT images of the pancreas to establish a quantitative imaging biomarker for type 2 diabetes mellitus.

Materials And Methods: In this retrospective study, 78 participants (45 with type 2 diabetes mellitus, 33 without) underwent a dual energy CT exam. Pancreas regions were segmented automatically using a deep learning algorithm.

Synergistic Effect of Small Molecular Organic Matter and Functional Groups in Coal on Methane Adsorption.

Functional groups and small-molecule organic matter are two key parts of coal. To explore the microscopic mechanism underlying the synergistic effect of both parts on methane adsorption, the oxygen-containing (-OH, -COOH, and -C=O) and nitrogen-containing (-NH) functional groups and two common small molecular organic matter methylbenzene and tetrahydrofuran-2-alcohol in coal are selected. The quantum chemical meta-GGA functional method is used to optimize all structures.

Composition analysis and health risk assessment of the hazardous compounds in cooking fumes emitted from heated soybean oils with different refining levels.

The cooking fumes generated from thermal cooking oils contains various of hazardous components and shows deleterious health effects. The edible oil refining is designed to improve the oil quality and safety. While, there remains unknown about the connections between the characteristics and health risks of the cooking fumes and oils with different refining levels.

Influences of Illumination Pretreatment on Soybean Oil Activated Clay Bleaching Effects and Soybean Oil Quality Evaluation.

Visible light has been widely studied for possible applications in food industry as being a kind of clean energy. Presently, the influences of illumination pretreatment on soybean oil quality followed by conventional activated clay bleaching, including the oil color, fatty acid composition, oxidation stability, and micronutrient content, were investigated. Results demonstrated that the illumination pretreatment increased the color differences between the non-illuminated and illuminated soybean oils, which indicated that the light exposure could improve the decoloring effects.

Pancreatic fat fraction in dual-energy computed tomography as a potential quantitative parameter in the detection of type 2 diabetes mellitus.

Purpose: To investigate the clinical value of measuring pancreatic fat fraction using dual-energy computed tomography (DECT) in association with type 2 diabetes mellitus (T2DM).

Materials And Methods: This retrospective study included patients who underwent abdominal DECT between September 2021 and July 2022. The fat fractions in the head, body, and tail of the pancreas were calculated using fat maps generated from unenhanced DECT images, and CT values were measured at the same locations.

ICSDA: a multi-modal deep learning model to predict breast cancer recurrence and metastasis risk by integrating pathological, clinical and gene expression data.

Breast cancer patients often have recurrence and metastasis after surgery. Predicting the risk of recurrence and metastasis for a breast cancer patient is essential for the development of precision treatment. In this study, we proposed a novel multi-modal deep learning prediction model by integrating hematoxylin & eosin (H&E)-stained histopathological images, clinical information and gene expression data.

polysacharin inhibits hepatocellular carcinoma-like phenotypes in a murine HCC model through repression of M2 polarization of tumour-associated macrophages.

Context: polysaccharin (APS), an extract of Schischk, exerts antitumor effects in hepatocellular carcinoma (HCC).

Objective: This study investigated the mechanism of action of APS in HCC.

Materials And Methods: Tumour-associated macrophages (TAMs) were treated with APS (0, 8, 16 mg/mL) for 24 h.

Predicting LncRNA-Disease Association by a Random Walk With Restart on Multiplex and Heterogeneous Networks.

Studies have found that long non-coding RNAs (lncRNAs) play important roles in many human biological processes, and it is critical to explore potential lncRNA-disease associations, especially cancer-associated lncRNAs. However, traditional biological experiments are costly and time-consuming, so it is of great significance to develop effective computational models. We developed a random walk algorithm with restart on multiplex and heterogeneous networks of lncRNAs and diseases to predict lncRNA-disease associations (MHRWRLDA).

Poor awareness and attitudes to sanitation servicing can impede China's Rural Toilet Revolution: Evidence from Western China.

The ongoing Toilet Revolution in China offers an opportunity to improve sanitation in rural areas by introducing new approaches, such as urine source separation, that can contribute to achieving SDG6. However, few studies have systematically assessed the social acceptability of managing human excreta collected in new sanitation systems. Therefore, in this study we performed face-to-face interviews with 414 local residents from 13 villages across three provinces in western China, to analyze the current situation and attitudes to possible changes in the rural sanitation service chain.

Failure of resting-state frontal-occipital connectivity in linking visual perception with reading fluency in Chinese children with developmental dyslexia.

It is widely accepted that impairment in visual perception impedes children's reading development, and further studies have demonstrated significant enhancement in reading fluency after visual perceptual training. However, the mechanism of the neural linkage between visual perception and reading is unclear. The purpose of this study was to examine the intrinsic functional relationship between visual perception (indexed by the texture discrimination task,TDT) and reading ability (character reading and reading fluency) in Chinese children with developmental dyslexia (DD) and those with typical development (TD).

Clinical and Imaging Analysis of Cerebral Infarction Caused by Spontaneous Cerebral Artery Dissection Based on Augmented Reality Technology.

In recent years, with the progress of population ageing, the incidence of a stroke caused by spontaneous dissection of the cerebral artery also increases with time. In order to address the health damage caused by a stroke caused by spontaneous dissection of the cerebral artery and to study its effect on human health, this article analyzes the incidence, type, electrocardiogram, and cardiovascular biomarker changes of cerebral infarction through statistical analysis and then discusses cerebral infarction. The pathogenesis and prevention measures of the disease are expected to provide better means for the treatment of cerebral infarction.

Attitudes of food consumers at universities towards recycling human urine as crop fertiliser: A multinational survey dataset.

We present here a data set generated from a multinational survey on opinions of university community members on the prospect of consuming food grown with human urine as fertiliser and about their urine recycling perceptions in general. The data set comprises answers from 3,763 university community members (students, faculty/researchers, and staff) from 20 universities in 16 countries and includes demographic variables (age bracket, gender, type of settlement of origin, academic discipline, and role in the university). Questions were designed based on Ajzen's theory of planned behaviour to elicit information about three components of behavioural intention-attitudes, subjective norms, and perceived behavioural control.

Occurrence of typical antibiotics, representative antibiotic-resistant bacteria, and genes in fresh and stored source-separated human urine.

Human urine is a source of fertilizer and, with proper management, it can be reused in agriculture. Determining the contamination issue of antibiotics in source-separated urine is important because the majority of antibiotics are excreted with urine. In this study, source-separated urine samples were randomly collected from a male toilet in a university building and analyzed in terms of 30 typical antibiotics (including 14 sulfonamides, 4 tetracyclines, and 12 fluoroquinolones) and tetracycline-resistant Escherichia coli, as well as its antibiotic-resistant genes to determine the contamination characteristics of antibiotic-related pollution in fresh and stored urine.

Stabilization of source-separated urine by heat-activated peroxydisulfate.

Source-separated urine is an attractive fertilizer due to its high nutrient content, but the rapidly hydrolysis of urea leads to ammonia volatilization and other environmental problems. Urine stabilization, which meanly means preventing enzymatic urea hydrolysis, receives increasing attention. Accordingly, this study developed a technique to stabilize fresh urine by heat-activated peroxydisulfate (PDS).

Protein sequence information extraction and subcellular localization prediction with gapped k-Mer method.

Background: Subcellular localization prediction of protein is an important component of bioinformatics, which has great importance for drug design and other applications. A multitude of computational tools for proteins subcellular location have been developed in the recent decades, however, existing methods differ in the protein sequence representation techniques and classification algorithms adopted.

Results: In this paper, we firstly introduce two kinds of protein sequences encoding schemes: dipeptide information with space and Gapped k-mer information.

Biodiesel Production Catalyzed by a Methanol-Tolerant Lipase A from in the Presence of Excess Water.

In this article, biodiesel was prepared using a novel free liquid lipase A from (CALA) as a catalyst in the presence of excess water. The methanol tolerance of CALA was investigated. The effect of reaction conditions, including the molar ratio of soybean oil to methanol, water load, CALA load, reaction temperature, and reaction time, was evaluated.

Erlotinib overcomes paclitaxel-resistant cancer stem cells by blocking the EGFR-CREB/GRβ-IL-6 axis in MUC1-positive cervical cancer.

Cancer stem cells (CSCs) are often enriched after chemotherapy and contribute to tumor relapse. While epidermal growth factor receptor (EGFR) tyrosine kinase inhibitors (TKIs) are widely used for the treatment of diverse types of cancer, whether EGFR-TKIs are effective against chemoresistant CSCs in cervical cancer is largely unknown. Here, we reveal that EGFR correlates with reduced disease-free survival in cervical cancer patients with chemotherapy.

Influence of ionic liquid on Novozym 435-catalyzed the transesterification of castor oil and ethyl caffeate.

Caffeic acid (CA), one kind of phenolic acids widely occurring in the plant kingdom, can be used as potential UV protective ingredient and antioxidant. However, the application of CA was limited because of its unsatisfactory solubility in hydrophilic and lipophilic media. In this work, BMIMPF, one kind of ionic liquids (ILs), was developed as an environmental friendly reaction media for the enzymatic preparation of CA derivatives by the transesterification of castor oil (CO) and ethyl caffeate (EC).

B(CF)-catalyzed Markovnikov addition of indoles to aryl alkynes: an approach toward bis(indolyl)alkanes.

The first example of the metal- and solvent-free B(C6F5)3-catalyzed Markovnikov addition of indoles to aryl alkynes was disclosed. Both N-H and N-protected indoles were tolerated, leading to a wide spectrum of versatile bis(indolyl)alkanes in moderate to good yields with high regioselectivities.

Development of Ferrocene-Based Diamine-Phosphine-Sulfonamide Ligands for Iridium-Catalyzed Asymmetric Hydrogenation of Ketones.

A series of air-stable, easily accessible tridentate ferrocene-based diamine-phosphine sulfonamide (f-diaphos) ligands were successfully developed for iridium-catalyzed asymmetric hydrogenation of ketones. The f-diaphos ligands exhibited excellent enantioselectivity and superb reactivity in Ir-catalyzed asymmetric hydrogenation of ketones (for arylalkyl ketones, ( S)-selectivity, up to 99.4% ee, and 100 000 TON; for diaryl ketones, ( R)-selectivity, up to 98.

Metal-Oxidant-Free Cobalt-Catalyzed C(sp)-H Carbonylation of ortho-Arylanilines: An Approach toward Free ( NH)-Phenanthridinones.

A traceless directing group assisted Co-catalyzed C(sp)-H carbonylation of ortho-arylanilines for the synthesis of free ( NH)-phenanthridinones in metal-based-oxidant-free fashion was accomplished. This protocol employs diisopropyl azodicarboxylate as the CO source and oxygen as the sole oxidant, and provides good yields with various functional tolerance. The methodology has been applied for the total synthesis of PARP inhibitor PJ-34.

MUC1 induces acquired chemoresistance by upregulating ABCB1 in EGFR-dependent manner.

Chemoresistance contributes to cancer relapse and increased mortality in a variety of cancer types, raising a pressing need to better understand the underlying mechanism. MUC1 is abnormally overexpressed in numerous carcinomas and associated with poor prognosis. However, the functional significance of MUC1 in chemoresistance has not been fully elucidated.