Intense Uptake of 68Ga-exendin-4 in a Patient With WHO Grade 3 Insulinoma and Extensive Intrahepatic Metastases.

A 24-year-old woman with hyperinsulinemic hypoglycemia was found with a pancreatic mass and multiple intrahepatic lesions in CT and MRI. 68Ga-exendin-4 PET/CT showed intense radioactivity in the pancreatic mass and all the intrahepatic lesions, suggesting a malignant insulinoma with multiple intrahepatic metastases. Subsequent fine needle biopsy confirmed the diagnosis of WHO grade 3 insulinoma.

Differences in Fibroinflammatory Activity Shown on Ga-FAPI-04 and F-FDG PET/CT in the Two Subtypes of IgG4-Related Disease.

IgG4-related disease (IgG4-RD) is a highly heterogeneous autoimmune disease. Recently, 2 subtypes of IgG4-RD, proliferative and fibrotic, were defined according to patients' clinicopathologic characteristics. The purpose of this study was to determine the difference in fibroinflammatory activity shown on Ga-FAPI-04 and F-FDG PET/CT in the proliferative and fibrotic IgG4-RD subtypes.

Clinical features of inflammatory arthritis in daily practice-China's perspective.

Objective: This study aimed to analyze and compare the proportion of patients with different types of inflammatory arthritis and investigate the clinical characteristics, including symptoms and signs, medication choices, and disease activity, in the daily clinical practice of China.

Methods: Patients with inflammatory arthritis were recruited from 16 Grade-A tertiary hospitals between August 2021 and April 2022. The medical profiles, encompassing sociodemographic characteristics, clinical and laboratory date, were collected.

68Ga-FAPI and 18F-NaF PET/CT in psoriatic arthritis: a comparative study.

Objectives: As fibroblast-like synoviocyte activation and bone formation are associated with psoriatic arthritis (PsA), positron emission tomography (PET) using the tracers of 68Ga-fibroblast activation protein inhibitor (FAPI) and 18F-sodium fluoride (NaF) may sensitively detect the disease. In this prospective study, we aimed to evaluate the performance of 68Ga-FAPI PET/CT in PsA and to compare it with 18F-NaF PET/CT.

Methods: Sixteen participants (female 7/16, age 42.

A preliminary study on the stability of bare footprint linear measurements in four motion states.

In some crime scenes, there may be bare footprints. Analyzing and testing the linear measurements of bare footprints in crime scenes can play an important role in personal analysis and individual identification. However, the linear measurements of bare footprints may be influenced by different motion states, leading to changes in length and width or even significant deviations.

Liver involvement with Langerhans cell histiocytosis in adults.

Background And Aims: Liver involvement portends poor prognosis in adults. We aimed to characterize the clinical features, liver function tests, radiologic findings, molecular profiles, therapeutic approaches and outcomes of adults patients with Langerhans cell histiocytosis (LCH) with liver involvement.

Methods: We conducted a retrospective analysis of all adults with LCH (≥ 18 years) seen at Peking Union Medical College Hospital (Beijing, China) between January 2001 and December 2022.

Baseline F-FDG PET/CT may contribute to the determination of initial treatment strategy for newly diagnosed follicular lymphoma.

Background: "Watch-and-wait" approach is an important management option in asymptomatic follicular lymphoma (FL) patients with low tumor burden. Since most FL lesions are FDG-avid, we wonder if F-FDG PET/CT at baseline can help to better choose the patients who can benefit from early chemotherapy. This study aimed to investigate the prognostic value of baseline F-FDG PET/CT in newly diagnosed FL patients treated with either watch-and-wait approach or chemotherapy.

Different extramedullary disease shown in chemokine receptor 4 targeted PET/CT with [ 68 Ga]Ga-pentixafor in patients with Waldenström macroglobulinemia and smoldering disease.

Introduction: It is important to distinguish Waldenström macroglobulinemia from smoldering Waldenström macroglobulinemia (sWM), because only patients with Waldenström macroglobulinemia require treatment, however the distinction can be clinically complex. The aim of this study is to investigate whether [ 68 Ga]Ga-pentixafor PET/CT shows different characteristics in sWM and Waldenström macroglobulinemia patients and therefore can help to differentiate Waldenström macroglobulinemia and sWM.

Results: Thirty-seven patients with newly diagnosed Waldenström macroglobulinemia and 11 sWM patients were analyzed [35 men and 13 women; 64.

Research on likelihood ratio evaluation method of fingerprint evidence based on parameter estimation method.

Unlabelled: Fingerprints with similar morphological characteristics but from different individuals can lead to errors in individual identification, especially when dealing with large databases containing millions of fingerprints. To address this issue and enhance the accuracy of similar fingerprint identification, the use of the likelihood ratio (LR) model for quantitative evaluation of fingerprint evidence has emerged as an effective research method. In this study, the LR fingerprint evidence evaluation model was established by using mathematical statistical methods, such as parameter estimation and hypothesis testing.

Similarity quantification of bare footprint based on linear measurement and shape context contour combined score-based likelihood ratio evaluation.

Bare footprints are a type of physical evidence that can be crucial for solving difficult cases. To assist with identification, we explored a similarity quantification method using 3062 bare footprints from 1391 volunteers. We used linear similarity to cover seven linear lengths and then calculated the contour similarity of the heel region, anterior margin, and toe region using the shape context.

[ Ga]Ga-FAPI-04 PET/CT may be a predictor for early treatment response in rheumatoid arthritis.

Background: The identification of biomarkers predicting the treatment response of rheumatoid arthritis (RA) is important. [ Ga]Ga-FAPI-04 showed markedly increased uptake in the joints of patients with RA. The purpose of this study is to investigate whether [ Ga]Ga-FAPI-04 PET/CT can be a predictor of treatment response in RA.

Cardiac Metastasis of Malignant Melanoma Detected by F-FDG PET/CT.

A 63-year-old man with a history of right plantar malignant melanoma (T3bN0M0, IIb) developed multiple metastases in bilateral lungs 19 months after surgery. Subsequent F-FDG PET/CT revealed multiple pulmonary metastases with intense FDG uptake and detected a hypermetabolic lesion in the lateral wall of the left ventricle, which was considered to be a cardiac metastasis of malignant melanoma. This lesion was later confirmed in the dynamic myocardial perfusion MR.

Renal Involvement of Immunoglobulin G4-Related Disease Presenting as a Solitary Hypermetabolic Mass Mimicking Renal Tumor on 18 F-FDG PET/CT.

A 62-year-old woman with a 5-year history of diabetes insipidus was found with a solitary renal mass in contrast-enhanced CT. 18 F-FDG PET/CT showed a hypermetabolic mass in the right kidney. Besides, there was increased uptake in the pituitary stalk.

Bing-Neel Syndrome and Coexisting Pituitary Macroadenoma in a Patient with Waldenström Macroglobulinemia Revealed by F-FDG and Ga-Pentixafor PET/CT.

A 63-year-old man presenting with peripheral neuropathies was diagnosed of Waldenström's macroglobulinemia, and Bing-Neel syndrome was subsequently confirmed via cerebrospinal fluid examinations. Besides involvement in bone marrow, lymph nodes, as well as the thoracic and sacral nerve root, Ga-Pentixafor PET/CT detected active tracer uptake in bilateral choroid plexus, which was negative in F-FDG PET/CT, possibly suggesting the involvement of Bing-Neel syndrome. The coexisting pituitary macroadenoma was FDG-avid but negative in Ga-Pentixafor PET/CT.

Characterizing Rosai-Dorfman disease with [F]FDG PET/CT: a retrospective analysis of a single-center study.

Objectives: Rosai-Dorfman disease (RDD) is a rare non-Langerhans cell histiocytic proliferative disorder. We performed a retrospective study to characterize the clinical and [F]FDG PET/CT features of RDD.

Methods: We retrospectively recruited 38 RDD patients with [F]FDG PET/CT scan in our center.

Ga-Pentixafor PET/CT May Fail to Detect Recurrent Multiple Myeloma with Extramedullary Disease.

Two patients with a history of multiple myeloma experienced a recurrence of the disease.F-FDG PET/CT revealed prominent extramedullary disease as well as multi-foci in the bone marrow, both with increased FDG uptake. However, on Ga-Pentixafor PET/CT, all the myeloma lesions showed significantly lower tracer uptake in comparison with F-FDG PET.

Prominent 68 Ga-FAPI Uptake in Renal Parenchyma Caused by Immunoglobulin G4-Related Nephropathy.

A 57-year-old man presented with a dry cough and renal insufficiency. Serum immunoglobulin G4 (IgG4) level was markedly elevated, and IgG4-related disease was clinically considered. 18 F-FDG PET/CT revealed mild uptake in salivary glands and also moderately increased activity in renal parenchyma and prostate.

Ga-FAPI PET/CT for Rheumatoid Arthritis: A Prospective Study.

Background In rheumatoid arthritis (RA), fibroblast-like synoviocyte cells, which are involved in inflammation of the articular cartilage and bone, overexpress fibroblast activation protein (FAP). This is a feature that could be leveraged to improve imaging assessment of disease. Purpose To determine the performance of gallium 68 (Ga)-labeled FAP inhibitor (FAPI) in assessing joint disease activity of RA and to compare with fluorine 18 (F) fluorodeoxyglucose (FDG) imaging.

Research on the local regional similarity of automatic fingerprint identification system fingerprints based on close non-matches in a ten million people database-Taking the central region of whorl as an example.

The local regional similarity of fingerprints has always been a hot issue in the field of fingerprint research. With the increasing size of ten-print databases, the appearance of close non-matches (CNMs) in automatic fingerprint identification system (AFIS) candidate lists has attracted increasing attention from forensic science departments worldwide. In this study, three categories (high-, medium-, and low-level) of standards for CNMs were established and 60 whorl samples were marked with different numbers of minutiae to explore the occurrence and influencing factors of CNMs in AFIS candidate lists based on a ten million people database.

New advances in Nrf2-mediated analgesic drugs.

Background: Oxidative stress is an inevitable process that occurs during life activities, and it can participate in the development of inflammation. Although great progress has been made according to research examining analgesic drugs and therapies, there remains a need to develop new analgesic drugs to fill certain gaps in both the experimental and clinical space.

Purpose: This review reports the research and preclinical progress of this class of analgesics by summarizing known nuclear factor E-2-related factor-2 (Nrf2) pathway-modulating substances.