Flexible Patterned Fuel Cell Patches Stimulate Nerve and Myocardium Restoration.

The distribution of electrical potentials and current in exogenous electrostimulation has significant impacts on its effectiveness in promoting tissue repair. However, there is still a lack of a flexible, implantable power source capable of generating customizable patterned electric fields for in situ electrostimulation(electrical stimulation). Herein, this study reports a fuel cell patch (FCP) that can provide in situ electrostimulation and a hypoxic microenvironment to promote tissue repair synergistically.

Effectiveness and Safety of Tenofovir Amibufenamide in the Treatment of Chronic Hepatitis B: A Real-world, Multicenter Study.

Background And Aims: Chronic hepatitis B (CHB) remains a significant global health challenge, and effective antiviral therapies are essential for long-term management. This study aimed to evaluate the real-world effectiveness and safety of tenofovir amibufenamide (TMF) in a cohort of patients with chronic hepatitis B (CHB).

Methods: In this multicenter, prospective, real-world cohort study, 194 CHB patients were recruited from four hospitals between August 2021 and August 2022.

High-Mobility, High-Photostability Tetravalent-Terbium-Doped Indium-Tin-Zinc-Oxide Thin-Film Transistors with a Stacked-Channel Structure.

The trade-off between mobility and stability is the main problem for amorphous oxide semiconductor (AOS) thin-film transistors (TFTs). In this work, a high-mobility and good-photostability Tb-doped indium-tin-zinc oxide (Tb:ITZO) AOS is studied. The ITZO TFT without Tb doping had a mobility of as high as 49.

Formation of electron-deficient Ni in a Nb/NiFe-layered double hydroxide nanoarray electrochemical activation for efficient water oxidation.

The intrinsically sluggish kinetics of the oxygen evolution reaction (OER) at the anode poses a formidable challenge to the industrial application of water electrolysis, although NiFe-based oxides and hydroxides have emerged as promising anodic candidates. Within this framework, we report the synthesis of Nb-doped NiFe-layered double hydroxides (Nb/NiFe-LDH) a straightforward one-step hydrothermal approach. Notably, Nb doping maintained the structural integrity of the NiFe-LDH framework and it enhanced the valence state of the active Ni species during the electrochemical activation process, which accelerated the concomitant reconstruction kinetics of the LDH phase.

Cryo-Shocked Tumor-Reprogrammed Sonosensitive Antigen-Presenting Cells Improving Sonoimmunotherapy via T Cells and NK Cells Immunity.

Ultrasound therapy has turned up as a noninvasive multifunctional tool for cancer immunotherapy. However, the insufficient co-stimulating molecules and loss of peptide-major histocompatibility complex I (MHC-I) expression on tumor cells lead to poor therapy of sonoimmunotherapies. Herein, this work develops a sonosensitive system to augment MHC-I unrestricted natural killer (NK) cell-mediated innate immunity and T cell-mediated adaptive immunity by leveraging antigen presentation cell (APC)-like tumor cells.

High quantum yield AIE covalent organic frameworks for sensitive pH monitoring, and copper toxicosis Diagnosis&Remission.

The luminescence properties of covalent organic frameworks (COFs) have attracted significant attention for biomedical applications. However, conventional fluorescent COFs often suffer from weak fluorescence due to aggregation-caused quenching (ACQ), limiting their utility. Given the critical need for highly efficient and sensitive biosensing tools, herein, we propose an aggregation-induced emission (AIE) COF, named COF-Bpy, with the quantum yield up to 25%.

Organophosphate Esters, Sperm Mitochondrial DNA Copy Number, and Semen Quality: A Longitudinal Study with Repeated Measurements.

Toxicological studies revealed that exposure to organophosphate esters (OPEs) affects semen quality, but human evidence is controversial. Over a 3-month follow-up, 1,385 healthy young men provided 3,550 urine samples and 6,466 semen samples, which were determined for urinary OPE metabolite concentrations, sperm quality parameters, and sperm mitochondrial DNA copy number (mtDNAcn). Linear mixed models revealed inverse associations between diphenyl phosphate (DPHP) concentrations and sperm concentration [-3.

Development and validation of a novel mortality risk stratification simplified scoring scale for severe fever with thrombocytopenia syndrome.

Objectives: The global incidence of severe fever with thrombocytopenia syndrome (SFTS) has markedly increased over the past decade. There is an urgent need to establish a reliable scoring system for predicting the mortality of patients with SFTS.

Methods: In this ambispective study, 714 patients with SFTS were recruited from 11 sites in China.

Peripheral Blood CD4/CD8 T Cell Ratio Predicts HBsAg Clearance in Inactive HBsAg Carriers Treated with Peginterferon Alpha.

Background And Aims: T lymphocytes play a pivotal role in resolving hepatitis B virus infection. This study aimed to investigate the dynamics of peripheral blood T lymphocyte subsets during peginterferon alpha (peg-IFN-α) therapy and their association with hepatitis B surface antigen (HBsAg) clearance in inactive HBsAg carriers (IHCs).

Methods: This prospective observational study enrolled 197 IHCs treated with peg-IFNα-2a/2b for 48 weeks and followed for 24 weeks (treatment group), and 221 IHCs who were regularly monitored for 72 weeks without treatment (IHC control group).

A microfluidic co-culture platform for lung cancer cells electrotaxis study under the existence of stromal cells.

Tumor metastasis is an important reason for the poor prognosis and high mortality in cancer patients. As major component of stromal cells in tumor microenvironment, cancer-associated fibroblasts (CAFs) secreted various factors to promote tumor metastasis. Studies have indicated that endogenous direct current electric field (dcEF) around tumor tissue induced directional migration of cancer cells.

Innovative diagnostic tool aids screening for minimal hepatic encephalopathy in non-alcoholic cirrhosis patients.

In this editorial we comment on the article by Jiang . We focus on the EncephalApp Stroop test which is an innovative, smartphone-based tool specifically designed for screening minimal hepatic encephalopathy (MHE) in cirrhosis patients. Traditional MHE screening methods, while highly sensitive and specific, are often complex, time-consuming, and require controlled environmental conditions, limiting their widespread clinical use.

Potential mechanisms and therapeutic prospects of the association between infection and metabolic dysfunction-associated steatohepatitis.

() infection is a known inducer of various gastrointestinal diseases, including gastritis, gastric ulcers, and gastric cancer. However, in recent years, research on the potential association between infection and metabolic dysfunction-associated steatohepatitis (MASH) has been scarce. This large-scale multicenter study, covering more than 360 hospitals across 26 medical systems in the United States, systematically evaluated the association between infection and MASH.

Superstrong Lightweight Aerogel with Supercontinuous Layer by Surface Reaction.

Breaking the thermal, mechanical and lightweight performance limit of aerogels has pivotal significance on thermal protection, new energy utilization, high-temperature catalysis, structural engineering, and physics, but is severely limited by the serious discrete characteristics between grain boundary and nano-units interfaces. Herein, a thermodynamically driven surface reaction and confined crystallization process is reported to synthesize a centimeter-scale supercontinuous ZrO nanolayer on ZrO-SiO fiber aerogel surface, which significantly improved its thermal and mechanical properties with density almost unchanged (≈26 mg cm). Systematic structure analysis confirms that the supercontinuous layer achieves a close connection between grains and fibers through Zr─O─Si bonds.

CHMP4C promotes pancreatic cancer progression by inhibiting necroptosis via the RIPK1/RIPK3/MLKL pathway.

Introduction: Pancreatic cancer (PC) cannot currently be completely cured and has a poor prognosis. Necroptosis is a distinct form of regulated cell death that differs from both necrosis and apoptosis. Understanding the role of necroptosis during PC progression would open new avenues for targeted therapy.

Synthesis, structures, and magnetic properties of alkali metal manganese(III) fluorophosphates containing low-dimensional = 2 spin structures.

Five alkali metal manganese(III) fluorophosphates, KMn(POF)F (I), RbMn(POF)F (II), RbMn(POF)(PO)F (III), RbMn(POF)(PO)F (IV), and CsMn(POF)F (V), were successfully synthesized using a hydrothermal method. The monofluorophosphate anion (POF) groups work as "chemical scissors" to promote low-dimensional spin structures with the aid of alkali metal cations. I and II had an = 2 uniform chain structure formed by corner-sharing -MnOF octahedra.

A Tribo/Piezoelectric Nanogenerator Based on Bio-MOFs for Energy Harvesting and Antibacterial Wearable Device.

New types of metal-organic framework (MOF) materials have great potential in solving the current global dilemma on energy, environment, and medical care. Herein, based on two kinds of biomolecule-MOFs (Bio-MOFs) with favorable biocompatibility and degradation-reconstruction characteristics, we have established a self-powered muti-functional device to achieve an efficient and broad-spectrum environmental energy collection and biomedical applications. Combining Zn(II) and carnosine-based Zn-Car_MOF possessing a high piezoelectric response (d = 11.

An updated review on abnormal epigenetic modifications in the pathogenesis of systemic lupus erythematosus.

Systemic lupus erythematosus (SLE) is a chronic autoimmune disease. The inconsistent prevalence of SLE between monozygotic twins suggests that environmental factors affect the occurrence of this disease. Abnormal epigenetic regulation is strongly associated with the pathogenesis of SLE.

Screening of single-atomic catalysts loaded on two-dimensional transition metal dichalcogenides for electrocatalytic oxygen reduction via high throughput ab initio calculations.

The design and screening of low cost and high efficiency oxygen reduction reaction (ORR) electrocatalysts is vital in the realms of fuel cells and metal-air batteries. Existing studies largely rely on the calculation of absorption free energy, a method established 20 years ago by Jens K. Nørskov.

Computer-Aided Design of Self-Assembled Nanoparticles to Enhance Cancer Chemoimmunotherapy via Dual-Modulation Strategy.

The rational design of self-assembled compounds is crucial for the highly efficient development of carrier-free nanomedicines. Herein, based on computer-aided strategies, important physicochemical properties are identified to guide the rational design of self-assembled compounds. Then, the pharmacophore hybridization strategy is used to design self-assemble nanoparticles by preparing new chemical structures by combining pharmacophore groups of different bioactive compounds.

Injectable supramolecular hydrogel co-loading abemaciclib/NLG919 for neoadjuvant immunotherapy of triple-negative breast cancer.

The efficacy of cancer immunotherapy relies on a sufficient amount of functional immune cells. Triple-negative breast cancer lacks enough immune cell infiltration, and adjuvant therapy is necessary to prime anti-tumor immunity. However, the improvement in efficacy is unsatisfactory with concern about inducing systemic immunotoxicity.

Open frameworks in the NaMn(PO)F fluoro-pyrophosphates system.

Three new sodium manganese fluoro-pyrophosphate compounds, namely, NaMn(PO)F (I), NaMn(PO)F (II), and NaMn(PO)F (III), have been synthesized by heating a mixture of NaPF, NaPOF or NaHPO with different Mn sources in NaNO and KNO fluxes. The structures of the title compounds were characterized single-crystal X-ray diffraction (XRD). II is characteristic of a shell of Na ions that encloses one [Mn(PO)F] unit, whereas I and III reveal three-dimensional (3D) frameworks that consist of MnO, Mn/NaOF octahedra or MnO octahedra and distorted MnO square pyramids with PO units, where Na cations reside in different-membered ring one-dimensional (1D) tunnels.

Targeting hypoxia and angiogenesis in hepatocellular carcinoma: New insights and therapeutic strategies.

In this manuscript we comment on the article by Yang published recently, focusing on how hepatic angiopoietin-2 (Ang-2) transcription promote the progression of hepatocellular carcinoma (HCC). HCC is one of the most common and lethal malignancies worldwide, especially in regions with high hepatitis B virus infection rates. Ang-2 is a key mediator of angiogenesis and plays a significant role in the progression of chronic liver diseases towards HCC, particularly in the hypoxic microenvironment.

OsPIL15-Induced Delay in Rice Heading Date via Direct Binding to the OsLF Promoter is Dependent on Functional Phytochrome B.

Heading date of rice (Oryza sativa) is a key factor determining rice production and regional adaptability. We analysed the molecular mechanism of OsPIL15, encoding phytochrome-interacting factor-like protein, in delaying rice heading date. Overexpression of OsPIL15 delayed rice heading date by upregulating Hd1 and inhibiting Hd3a and RFT1 expression.

A prodrug nanodevice co-delivering docetaxel and ROR1 siRNA for enhanced triple negative breast cancer therapy.

Triple-negative breast cancer (TNBC) has been a clinical challenge due to its high recurrence and metastasis rates. Chemotherapy remains the primary treatment for TNBC after surgery ablation, but it lacks targeted specificity and causes side effects in normal tissues. Receptor tyrosine kinase-like orphan receptor 1 (ROR1) is significantly expressed in TNBC cells, and small interference RNA (siRNA) targeting ROR1 can effectively suppress ROR1 gene expression, thereby inhibiting proliferation and metastasis.