ROS-responsive simvastatin nano-prodrug based on tertiary amine-oxide zwitterionic polymer for atherosclerotic therapy.

Atherosclerosis (AS) is a major cause of cardiovascular disease and is characterized by high levels of reactive oxygen species (ROS) and lipid deposition. This study utilized ROS-responsive oxalate bonds to conjugate simvastatin (SV) and tertiary amine-oxide zwitterionic polymer (OPDH), resulting in the design of a ROS-responsive simvastatin nano-prodrug (OPDH-SV). In vitro experiments have proved that OPDH-SV has excellent stability and low toxicity, can effectively reduce intracellular ROS and lipid levels, and inhibit foam cells formation.

How does light regulate plant regeneration?

Based on the totipotency and pluripotency of cells, plants are endowed with strong regenerative abilities. Light is a critical environmental factor influencing plant growth and development, playing an important role in plant regeneration. In this article, we provide a detailed summary of recent advances in understanding the effects of light on plant regeneration, with a focus on the fundamental processes and mechanisms involved in shoot regeneration, somatic embryogenesis, and adventitious root formation.

Data-driven controller design of discrete-time switched systems using virtual clock approach.

This paper presents a novel data-driven controller design methodology for discrete-time switching systems, emphasizing reduced conservativeness. This approach leverages both lifting and virtual clock approaches to achieve this goal. The paper thoroughly examines different application scenarios, including noise-free state measurable, noise-free state unmeasurable, and the consideration of noise.

GATA2 links stemness to chemotherapy resistance in acute myeloid leukemia.

Stemness-associated cell states are linked to chemotherapy resistance in AML. We uncovered a direct mechanistic link between expression of the stem cell transcription factor GATA2 and drug resistance. The GATA-binding protein 2 (GATA2) plays a central role in blood stem cell generation and maintenance.

Comparative transcriptome and metabolome analysis of sweet potato ( (L.) Lam.) tuber development.

Introduction: Sweet potato is an important food, feed and industrial raw material, and its tubers are rich in starch, carotenoids and anthocyanins.

Methods: To elucidate the gene expression regulation and metabolic characteristics during the development of sweet potato tubers, transcriptomic and metabolomic analyses were performed on the tubers of three different sweet potato varieties at three developmental stages (70, 100, and 130 days (d)).

Results: RNA-seq analysis revealed that 16,303 differentially expressed genes (DEGs) were divided into 12 clusters according to their expression patterns, and the pathways of each cluster were annotated.

Molecular Beam Epitaxial Growth and Optical Properties of InN Nanostructures on Large Lattice-Mismatched Substrates.

Narrow-gap InN is a desirable candidate for near-infrared (NIR) optical communication applications. However, the absence of lattice-matched substrates impedes the fabrication of high-quality InN. In this paper, we employed Molecular Beam Epitaxy (MBE) to grow nanostructured InN with distinct growth mechanisms.

Environmental Impact of Xenobiotic Aromatic Compounds and Their Biodegradation Potential in .

Xenobiotic aromatic compounds are the raw materials of necessities in modern life, such as plastics, pesticides, and antibiotics. To meet the global requirements, their production and consumption have continually increased, and thus, the vast amount of waste generated results in prominent environmental pollution. Fortunately, some microorganisms (e.

Transition metal-catalyzed cascade C-H activation/cyclization with alkynes: an update on sulfur-containing directing groups.

In light of the extensive applications of sulfur-containing heterocyclic compounds in drug discovery, agrochemicals, and advanced materials, the construction of complex sulfur-containing molecular scaffolds has flourished in recent years. There is a profound interest in synthetic methods for forming carbon-sulfur bonds. Regarding this, transition metal (TM)-catalyzed C-H bond activation has emerged as a valuable means for the rapid formation of C-S bonds, although it is comparatively less explored than C-N or C-C bonds.

Designing cobalt-nickel dual-atoms on boron, nitrogen-codoped carbon nanotubes for carbon dioxide electroreduction to syngas.

Developing highly efficient electrocatalysts to produce syngas with a stable hydrogen/carbon monoxide (H/CO) ratio in a wide potential window via electrochemical carbon dioxide (CO) reduction is desperately required but still challenging. Herein, a dual-atomic site on boron, nitrogen-codoped carbon nanotubes (BCN) has been designed, containing both cobalt (CoN) and nickel (NiNB) sites. Benefiting from the structure advantage and the bifunctional Co/Ni sites, such designed catalyst (CoNi-BCN) demonstrates remarkable performance for syngas production, achieving a stable H/CO ratio of 1.

Bioinspired catalytic pocket promotes CO-to-ethanol photoconversion on colloidal quantum wells.

Sluggish surface reaction is a critical factor that strongly governs the efficiency of photocatalytic solar fuel production, particularly in CO-to-ethanol photoconversion. Here, inspired by the principles underlying enzyme catalytic proficiency and specificity, we report a biomimetic photocatalyst that affords superior CO-to-ethanol photoreduction efficiency (5.5 millimoles gram hour in average with 98.

Wild rice GL12 synergistically improves grain length and salt tolerance in cultivated rice.

The abounding variations in wild rice provided potential reservoirs of beneficial genes for rice breeding. Maintaining stable and high yields under environmental stresses is a long-standing goal of rice breeding but is challenging due to internal trade-off mechanisms. Here, we report wild rice GL12 improves grain length and salt tolerance in both indica and japonica genetic backgrounds.

DNA Hypomethylation Activates the RpMYB2-Centred Gene Network to Enhance Regeneration of Adventitious Roots.

Plants, being immobile, are exposed to environmental adversities such as wind, snow and animals that damage their structure, making regeneration essential for their survival. The adventitious roots (ARs) primarily emerge from a detached explant to uptake nutrients; therefore, the molecular network involved in their regeneration needs to be explored. DNA methylation, a key epigenetic mark, influences molecular pathways, and recent studies suggested its role in regeneration.

An End-to-End Knowledge Graph Fused Graph Neural Network for Accurate Protein-Protein Interactions Prediction.

Protein-protein interactions (PPIs) are essential to understanding cellular mechanisms, signaling networks, disease processes, and drug development, as they represent the physical contacts and functional associations between proteins. Recent advances have witnessed the achievements of artificial intelligence (AI) methods aimed at predicting PPIs. However, these approaches often handle the intricate web of relationships and mechanisms among proteins, drugs, diseases, ribonucleic acid (RNA), and protein structures in a fragmented or superficial manner.

207-27 alters the microbiota-gut-brain axis to improve wearable device-measured sleep duration in healthy adults: a randomized, double-blind, placebo-controlled trial.

: Probiotics have been reported to exert beneficial effects on sleep through the gut-brain axis. Therefore, this randomized, double-blind, placebo-controlled trial assessed the effects of 207-27 supplementation on sleep quality and its safety and potential mechanisms. : Healthy adults under mild stress aged 18-35 years consumed low or high doses of 207-27 or a placebo for 28 days.

Ni Cluster-Decorated Single-Atom Catalysts Achieve Near-Unity CO-to-CO Conversion with an Ultrawide Potential Window of ≈1.7 V.

Developing efficient electrocatalysts for CO reduction to CO within a broad potential range is meaningful for cascade application integration. In this work, hydrogen spillover is created and utilized to cultivate a proton-rich environment via the simple thermolysis of a Ni-doped Zn coordination polymer (Zn CPs (Ni)) to create asymmetric Ni single atoms co-located with adjacent Ni nanoclusters on nitrogen-doped carbon, termed as Ni/N-C, which expedites the hydrogenation of adsorbed CO. Therefore, the sample demonstrates near-unity CO-to-CO conversion efficiency under pH-universal conditions in ultra-wide potential windows: -0.

Risk early warning for unmanned aerial vehicle operators' unsafe acts: A prediction model using Human Factors Analysis and Classification System and random forest.

The prediction of unmanned aerial vehicle (UAV) operators' unsafe acts is critical for preventing UAV incidents. However, there is a lack of research specifically focusing on UAV operators' unsafe acts, and existing approaches in related areas often lack precision and effectiveness. To address this, we propose a hybrid approach that combines the Human Factors Analysis and Classification System (HFACS) with random forest (RF) to predict and warn against UAV operators' unsafe acts.

UVaT: Uncertainty Incorporated View-Aware Transformer for Robust Multi-View Classification.

Existing multi-view classification algorithms usually assume that all examples have observations on all views, and the data in different views are clean. However, in real-world applications, we are often provided with data that have missing representations or contain noise on some views (i.e.

Endocytosis: the match point of nanoparticle-based cancer therapy.

Nanomedicine has inspired a ground-breaking strategy for cancer therapy. By intelligently assembling diverse moieties to form nanoparticles, numerous functionalities such as controlled release, synergistic efficiency, and killing can be achieved. The emerging nanoparticles have been designed with elevated targeting efficiency as targeting cancer cells is the primary requirement for nanoparticles.

Copper Atom Pairs Stabilize *OCCO Dipole Toward Highly Selective CO Electroreduction to CH.

Deeply electrolytic reduction of carbon dioxide (CO) to high-value ethylene (CH) is very attractive. However, the sluggish kinetics of C-C coupling seriously results in the low selectivity of CO electroreduction to CH. Herein, we report a copper-based polyhedron (Cu2) that features uniformly distributed and atomically precise bi-Cu units, which can stabilize *OCCO dipole to facilitate the C-C coupling for high selective CH production.

The resistance to anoikis, mediated by Spp1, and the evasion of immune surveillance facilitate the invasion and metastasis of hepatocellular carcinoma.

Anoikis-Related Genes (ARGs) lead to the organism manifesting resistance to anoikis and are associated with unfavorable prognostic outcomes across various malignancies.Therefore, it is crucial to identify the pivotal target genes related to anoikis in HCC .We found that ARGs were significantly correlated with prognosis and immune responses in HCC.

A pH-triggered N-oxide polyzwitterionic nano-drug loaded system for the anti-tumor immunity activation research.

Triple negative breast cancer (TNBC) has the characteristics of low immune cell infiltration, high expression of tumor programmed death ligand 1 (PD-L1), and abundant cancer stem cells. Systemic toxicity of traditional chemotherapy drugs due to poor drug selectivity, and chemotherapy failure due to tumor drug resistance and other problems, so it is particularly important to find new cancer treatment strategies for TNBC with limited treatment options. Both the anti-tumor natural drugs curcumin and ginsenoside Rg3 can exert anti-tumor effects by inducing immunogenic cell death (ICD) of tumor cells, reducing PD-L1 expression, and reducing cancer stem cells.

Dress me an outfit: advanced probiotics hybrid systems for intelligent IBD therapy.

Inflammation bowel disease (IBD) has emerged as a public health challenge worldwide; with high incidence and rapid prevalence, it has troubled billions of people and further induced multitudinous systemic complications. Recent decade has witnessed the vigorous application of food-borne probiotics for IBD therapy; however, the complicated and changeable environments of digestive tract have forced probiotics to face multiple pressures, consequently causing unsatisfied prophylactic or therapeutic efficacy attributed to off-targeted arrival, damaged viability, insufficient colonization efficiency, etc. Fortunately, arisen hybrid technology has provided versatile breakthroughs for the targeted transplantation of probiotics.

Effects of Bifidobacterium breve 207-1 on regulating lifestyle behaviors and mental wellness in healthy adults based on the microbiome-gut-brain axis: a randomized, double-blind, placebo-controlled trial.

Purpose: Our study aimed to explore the efficacy of Bifidobacterium breve 207-1 on specific neurotransmitters and hormones and the ability to regulate lifestyle behaviors in healthy adults.

Methods: In total, 120 healthy adults with high mental stress, overweight, insomnia, and constipation were randomly assigned to receive low-dose B. breve 207-1 (LD, n = 40), high-dose B.