Diverse anti-inflammatory lindenane sesquiterpenoid hetero- or homo-dimers from Chloranthus holostegius var. shimianensis.

Twenty-seven dimeric lindenane sesquiterpenoid (LS) derivatives, including thirteen new hetero- or homo-dimers (1-13), were discovered from rare Chloranthaceae plant Chloranthus holostegius var. shimianensis. Their structures were elucidated by a combination of HRMS, spectroscopic analysis, single-crystal X-ray diffraction and CD exciton chirality method.

Enhancing RBP4 protein detection in clinical urine samples with solid-state nanopores through optimized sandwich immunoassay techniques.

Nanopore technology is a promising single-molecule sensing platform that can identify substances through the precise monitoring of changes in ion currents. However, protein detection in clinical samples using solid-state nanopores remains challenging due to their heterogeneously charged spherical structure, which results in signals with extremely low signal-to-noise ratios (SNR) and low capture rates that are difficult to analyze. In this study, we employed a double-antibody sandwich technique to specifically capture and amplify the target antigen, which significantly improves the SNR and effectively distinguishes the target signal from background interference.

Heat exposure and respiratory diseases health outcomes: An umbrella review.

Introduction: Heat exposure and heatwaves are becoming more frequent and prolonged due to global warming. Heat exposure poses a significant potential risk for respiratory diseases. However, a comprehensive synthesis of existing evidence on the health impacts of heat exposure on respiratory diseases is lacking.

Copper contamination determined the impact of phages on microbially-driven nitrogen cycling in coastal wetland sediments.

Phages have garnered increasing attention due to their potential roles in biogeochemical cycling. However, their impacts on nitrogen cycling have primarily been inferred from the presence of putative auxiliary metabolic genes (AMGs) and the virus-host linkage, despite of very limited direct experimental evidence. In this study, a series of microcosms were established with the inoculation of either native or non-native phages to simulate coastal wetlands with different phage sources and different levels of copper (Cu) contamination.

Application of Structured Education Management in Standardized Treatment of Cancer Pain.

In China, the drug treatment of many cancer pain patients is obviously affected by people's lack of knowledge and confidence, and cancer pain symptoms fail to be effectively controlled. This retrospective case-control study explored the effect of application of structured education management in standardized treatment of cancer pain. Eligible cancer pain patients from June 2022 to April 2023 were selected as the control group.

SKA3 promotes lung adenocarcinoma progression via the EGFR/E2F1/SKA3/integrin β1 signaling loop.

Spindle and kinetochore-associated complex subunit 3 (SKA3) contributes to tumor growth and metastasis, but its specific roles have not been clearly elucidated. In this study, we found that SKA3 contributed to lung adenocarcinoma (LUAD) progression by interacting with integrin β1. The expression characteristics of SKA3 in LUAD patients were analyzed by The Cancer Genome Atlas (TCGA) and Gene Expression Omnibus (GEO) datasets and validated in 33 paired LUAD tissues by immunohistochemistry.

Defining histamine H2 receptor antagonist response in critically ill patients with heart failure: a machine learning cluster analysis.

Background: Recent studies showed histamine H2 receptor antagonists (H2RAs) exposure was associated with reduced mortality in heart failure (HF) patients. However, specific HF patients who are sensitive to H2RAs exposure or not are yet to be further defined.

Aim: This study aimed to identify HF patient characteristics that may benefit from H2RAs exposure.

Neonatal lupus erythematosus presenting with congenital heart block: clinical characteristics and follow-up.

Objective: Congenital heart block (CHB) in patients with neonatal lupus erythematosus (NLE) is usually irreversible. Our study aimed to investigate the clinical characteristics and prognostic follow-up results of patients with NLE presenting with CHB and to provide a reference for the clinical treatment and management of such patients.

Methods: Six patients with NLE and CHB at the Children's Hospital of Soochow University between January 1, 2011, and December 31, 2023, were retrospectively analyzed.

tRF-Pro-CGG Suppresses Cell Proliferation and Promotes Apoptosis in Pancreatic Cancer.

Objective: This study aimed to investigate the role of tRNA-derived RNA fragment tRF-Pro-CGG in pancreatic cancer (PC), focusing on its expression levels in PC tissues and cell lines, and its effects on cell proliferation, clonality, migration, invasion, and apoptosis. Additionally, the study explored the potential of tRF-Pro-CGG as a diagnostic biomarker and therapeutic target in PC.

Methods: The expression levels of tRF-Pro-CGG in PC tissues and cell lines were analyzed using next-generation sequencing and quantitative real-time PCR (qRT-PCR).

Association between leukocyte telomere length and renal cell carcinoma: insight from Mendelian randomization study.

Background: To investigate whether leukocyte telomere length (LTL) causally influences renal cell carcinoma (RCC) risk, this study applied Mendelian randomization (MR) analysis. Prior research examining LTL as a potential biomarker for RCC risk has yielded inconsistent findings.

Methods: We obtained summary-level LTL data from the UK Biobank genome-wide association study (n = 472,174) and gathered RCC data from both the FinnGen Consortium (n = 289,360) and the International Agency for Research on Cancer (IARC) (n = 13,230).

Gut metabolites and functional recovery after ischemic stroke: a genetic perspective.

The current study explores the relationship between genetically predicted gut metabolites and functional outcomes following ischemic stroke, utilizing the Mendelian Randomization (MR) framework. Genetic information regarding gut microbiota-derived metabolites was sourced from 2076 participants of European descent participating in the Framingham Heart Study. Data on functional outcomes 90 days post-ischemic stroke were acquired from the Genetics of Ischemic Stroke Functional Outcomes Network (n = 6,021).

Effectiveness, safety, and patterns of use of camrelizumab in advanced esophageal cancer: an individual patient data pooled analysis of 987 patients from three prospective cohort studies.

Background And Aims: This individual patient data pooled analysis aimed to evaluate the effectiveness, safety, and patterns of use of camrelizumab in a large cohort of advanced esophageal cancer (AEC) patients.

Approach And Results: Adult patients (≥ 18 years) who had received camrelizumab as part of AEC treatment were pooled from three independent, prospective observational cohort studies (NCT04616040, ChiCTR1900027275, and ChiCTR2000039499). The main outcomes were patterns of camrelizumab use, progression-free survival (PFS), overall survival (OS), and safety in the overall population and specific subgroups of underrepresented patients.

Olfactomedin 4 promotes gastric cancer cell G2/M progression and serves as a therapeutic target in gastric adenocarcinoma.

Olfactomedin 4 (OLFM4) is a member of the olfactomedin domain-containing olfactomedin glycoprotein family and plays important roles in innate immunity, inflammation, and cancer. It exhibits increased expression in gastric cancer patient tissues and has been shown to regulate proliferation and apoptosis in gastric cancer cells. However, the molecular mechanism(s) underlying OLFM4's role in gastric cancer remain unknown.

A Multiagent-Driven Robotic AI Chemist Enabling Autonomous Chemical Research On Demand.

The successful integration of large language models (LLMs) into laboratory workflows has demonstrated robust capabilities in natural language processing, autonomous task execution, and collaborative problem-solving. This offers an exciting opportunity to realize the dream of autonomous chemical research on demand. Here, we report a robotic AI chemist powered by a hierarchical multiagent system, ChemAgents, based on an on-board Llama-3.

Enhancement of Proton Conductivity in Water and Aqua-Ammonia Vapor by Incorporating Sulfonic Acid-Functionalized Polymer into MIL-101-SOH.

The design and preparation of super proton conducting metal-organic frameworks (MOFs) are of great significance for the advancement of proton exchange membrane fuel cells (PEMFCs). An effective approach to increase the sulfonic acid density and control the hydrogen bonding networks within MOFs involves incorporating polymer chains that contain sulfonic acid groups into their pore structures. In this work, we report the synthesis of a polyvinyl sulfonic acid (PVS) cross-linked polymer within the nanopores of MIL-101-SOH, resulting in the PVS@MIL-101-SOH composite.

Marine Transport Barrier for Traditional and Emerging Per- and Polyfluoroalkyl Substances in the Southeast Indian Ocean and Antarctic Marginal Seas.

Traditional per- and polyfluoroalkyl substances (PFASs) have been observed in the remote Southern Ocean. In contrast, current knowledge about emerging PFASs, such as perfluoroether carboxylic acids (PFECAs), and their transport mechanisms remains ambiguous. In this study, the occurrence and transport of both traditional and emerging PFASs in the surface seawater of the Southeast Indian Ocean and Antarctic marginal seas are comprehensively discussed by integrating hydrological data.

Single-Crystalline β-GaO Homoepitaxy on a Near Van der Waals Surface of (100) Substrate.

Gallium oxide (Ga₂O₃) is a promising wide-bandgap semiconductor for power devices, offering high breakdown voltage and low on-resistance. Among its polymorphs, β-Ga₂O₃ stands out due to the availability of high-quality, large-area single-crystalline substrates, particularly on the (100) surface, grown via melt-based bulk crystal growth. However, the low surface energy of β-Ga₂O₃ (100), akin to 2D materials, presents challenges in homoepitaxy, including poor nucleation and twin formation, which hinder its practical application.

Enhanced Photoluminescence Emission and Thermal Stability in Pt1Ag31 nanocluster from Introduced Secondary Phosphine Oxide Functionalized ligand.

Surface ligands significantly influence the optical properties and stability of metal nanoclusters. In this study, we synthesized [Pt1Ag31(S-Adm)16(DPPM)3(DPPMO)Cl3](SbF6)4 (Pt1Ag31-DPPMO). Compared to [Pt1Ag31(S-Adm)16(DPPM)3Cl3](SbF6)4 (Pt1Ag31), the introduction of secondary phosphine oxide ligand, DPPMO, results in Pt1Ag31-DPPMO exhibiting enhanced photoluminescent properties in both solution and solid states, as well as improved stability and electron-withdrawing ability.

Prognostic Value of CD133 and SOX2 Expression After Neoadjuvant Chemotherapy in Patients with Locally Advanced Gastric Cancer.

Background: To investigate the expression and associations of putative stem cell markers with survival in patients with locally advanced gastric cancer (GC) receiving neoadjuvant chemotherapy.

Methods: This study included 180 patients with locally advanced GC who received neoadjuvant chemotherapy and subsequent radical gastrectomy between June 2010 and December 2014. Surgical paraffin samples from the enrolled patients were collected.

Endogenous Bacterial Endophthalmitis Complicating Hemodialysis Catheter-Related Sepsis: A Case Report and Review of the Literature.

Background: Endogenous endophthalmitis is an infrequent yet severe complication of hemodialysis catheter-related sepsis. In this report, we present a case of endogenous bacterial endophthalmitis in a patient with hemodialysis catheter-related sepsis.

Case Presentation: A 65-year-old male had a history of hepatitis B-related glomerulonephritis, end-stage renal disease, hepatitis-B-related decompensated cirrhosis, hypertension, diabetes mellitus, and coronary artery disease.

Pathogenesis and treatment of perioperative hiccups: a narrative review.

Introduction: Hiccups affect 0.05% of general in-patients and up to 10% of patients with gastroesophageal reflux disease. Hiccups are typically self-limited.

Prevalence and Risk Factors of Chemotherapy-Induced Oral Mucositis in 470 Children With Acute Lymphoblastic Leukemia.

Objective: To assess the prevalence and risk factors of chemotherapy-induced oral mucositis in 470 children with acute lymphoblastic leukemia in China, focusing on treatment-related risk factors.

Methods: This cross-sectional study included 470 children diagnosed with acute lymphoblastic leukemia in China from January 2020 to July 2022. Data were collected from electronic medical records, field investigations, and telephone follow-ups, covering sociodemographic characteristics, nutritional status, disease and treatment history, and microbiological factors.

PGK1 enhances productive bovine herpesvirus 1 infection by stimulating β-catenin-dependent transcription.

Bovine herpesvirus 1 (BoHV-1) productive infection stimulates β-catenin-dependent transcription to facilitate virus replication. Phosphoglycerate kinase 1 (PGK1), which catalyses the initial step of ATP production during glycolysis, also has a mitochondrial form that is implicated in tissue injury across various diseases. However, the relationship between BoHV-1 replication and the PGK1 signalling pathway is not yet fully understood.