Neonatal lupus erythematosus: an acquired autoimmune disease to be taken seriously.

Aim: This review aims to summarize the epidemiology, pathogenesis, clinical features, management, prognosis and regression of Neonatal lupus erythematosus (NLE) with a view to providing directions for standardized diagnosis, treatment and further research.

Methods: We conducted a comprehensive literature review of NLE. NLE-related peer-reviewed papers were searched through PubMed/Medline were searched up to November 2024.

Electrochromic Pressure-Sensitive Device for In Situ and Instantaneous Pressure Visualization.

High sensitivity and spatial recognition of pressure sensors are important for application of the sensors in electronic skins, and in situ visualization is a practical and effective approach to identifying pressure information. Here, we present a facial strategy to achieve in situ pressure information recognition that is visible to the naked eye in coloring form by designing an HPO/PVA film with hemispheric microstructures in an integrated electrochromic pressure sensor. The device can be applied for different stress scenarios within the range of 0-250 kPa by adjusting the spacing of hemispheric microstructures and can identify the magnitude, position, shape, and duration of the pressure.

Noncontact Detection of Blood Coagulation Dynamics Based on Speckle Deviation Analysis Using Optical Coherence Tomography.

Red blood cells aggregate from individual cells into larger aggregates during blood coagulation. This process causes the light-scattering particles to enlarge and their motion to become restricted. The size and motion of these light-scattering particles during coagulation provide valuable information on the progress of blood coagulation.

In Situ Electrochemical Activation Strategy toward Organic Cation Preintercalated Layered Vanadium-Based Oxide Cathode for High-Performance Aqueous Zinc-Ion Batteries.

Layered vanadium-based oxides with preintercalated metal cations are attracting extensive attention as highly promising candidates for aqueous zinc-ion batteries (AZIBs) due to the increase in structural stability originating from the pillar effect. However, the strong electrostatic interaction between the rigid metal cation pillars and zinc ions results in sluggish ionic transport, thereby limiting the high-rate performance. Herein, a layered vanadium-based oxide with protonated 1,4-diaminobutane organic cation (BDA) pillars is designed as a cathode material for AZIBs.

Patulin Detoxification by Evolutionarily Divergent Reductases of ATCC 621.

The mycotoxin patulin in processed apple juice poses a significant threat to food safety, driving the need for effective detoxification strategies. ATCC 621 can detoxify patulin to ascladiol using either the short-chain dehydrogenases/reductases (SDRs)─GOX0525, GOX1899, and GOX0716─or the aldo-keto reductase (AKR) GOX1462. While GOX0525 and GOX1899 have been previously characterized, this study focuses on GOX0716 and GOX1462, evaluating their optimal pH, thermostability, thermoactivity, and substrate specificity, thereby completing the characterization of all four reductases.

Mesoporous Nanogel Sprays as Universal Evaporation Interface Modifiers for Boosting Water-Cluster Evaporation.

Accelerating water evaporation is vital for processes like photosynthesis, dehydration, and desalination. Optimizing the pore structure and interfacial properties of evaporative materials can reduce evaporation enthalpy and increase efficiency. However, integrating the evaporation interface with water transport channels poses significant design challenges and complicates low-enthalpy evaporation analysis.

A Comprehensive Review of Traditional Chinese Medicine in the Management of Ulcerative Colitis.

Ulcerative colitis (UC) is a chronic, nonspecific inflammatory disorder characterized by symptoms such as abdominal pain, diarrhea, hematochezia, and urgency during defecation. While the primary site of involvement is the colon, UC can extend to encompass the entire rectum and colon. The causes and development mechanisms of UC are still not well understood; nonetheless, it is currently held that factors including environmental influences, genetic predispositions, intestinal mucosal integrity, gut microbiota composition, and immune dysregulation contribute to its development.

Highly Stable, Excellent Foliar Adhesion and Anti-Photodegradation Nucleic Acid-Peptide Coacervates for Broad Agrochemicals Delivery.

Agrochemicals play a pivotal role in the management of pests and diseases and the way agrochemicals are utilized exerts significant impacts on the environment. Ensuring rational application and improving utilization rates of agrochemicals are major demands in developing green delivery systems. Herein, a model of nucleic acid-peptide coacervate (NPC) for agrochemical delivery is presented, which is formed by mixing negatively charged single-stranded DNAs with positively charged poly-L-lysine.

Survival benefits of postoperative radiotherapy in esophageal cancer during the immunotherapy era:a retrospective cohort study based on the SEER database and a single-center registry in China.

Purpose: The aim of this study was to investigate the survival benefits of postoperative radiotherapy (PORT) in patients with resectable esophageal cancer (EC) after neoadjuvant therapy in the Immunotherapy era.

Methods: The study was designed as a retrospective cohort study, which included a total of 733 patients with EC from the SEER database and a single-center cohort. We used propensity score matching (PSM) to equilibrate patient characteristics.

Identification and functional characterization of T-cell exhaustion-associated lncRNA AL031775.1 in osteosarcoma: a novel therapeutic target.

Background: Osteosarcoma, an aggressive bone malignancy predominantly affecting children and adolescents, presents significant therapeutic challenges with a 5-year survival rate below 30% in metastatic cases. T-cell exhaustion, characterized by the overexpression of immune checkpoint molecules, contributes to osteosarcoma progression and immune evasion. Although targeting these inhibitory pathways has shown potential in restoring T-cell activity, the molecular regulators of T-cell depletion in osteosarcoma are poorly understood.

Case Report: Complete response to four cycles of camrelizumab in a PD-L1 negative patient with advanced oral squamous cancer.

Immunotherapy has brought better survival benefits in the treatment of recurrent or metastatic head and neck squamous cell carcinoma (R/M HNSCC). However, owing to the lack of relevant biomarkers that could predict the efficacy of this treatment, it often has to be maintained. Here we report on a patient with stage IVA squamous cell carcinoma of the tongue who developed an unresectable lesion in the neck after surgery and radical chemoradiotherapy.

Minocycline-Loaded Titanium Dioxide Nanoparticles for Augmented Synergistic Periodontal Sonodynamic Chemotherapy.

Background: The current clinical treatment of periodontitis usually involves mechanical removal of pathogenic bacteria through ultrasonic scaling and root planing, supplemented with antibacterial medications to inhibit microbial overgrowth. However, the therapeutic efficiency remains unsatisfactory due to complicated periodontal anatomy, limited plaque removal, short retention of antibiotics, and related side effects.

Methods And Results: To address these issues, we successfully synthesized mesoporous titanium dioxide nanoparticles (MTN) via a sol-gel method, which were modified with hemoglobin (Hb) and loaded with minocycline (MINO).

Predictive factors for visual prognosis in neurosyphilis presenting with optic atrophy: a Chinese case series study.

Background: We aimed to explore the clinical features and predictive factors for visual prognosis of neurosyphilis-associated optic atrophy (NSAOA).

Methods: This retrospective observational study included 17 patients (33 eyes) with NSAOA who received standard anti-ocular syphilis treatment. LogMAR (logarithm of the minimum angle of resolution) best-corrected visual acuity (BCVA), visual field, and optical coherence tomography, were recorded at baseline, short-term (within one month after treatment), and long-term (> 6 months) follow-up.

Asiaticoside-nitric oxide synergistically accelerate diabetic wound healing by regulating key metabolites and SRC/STAT3 signaling.

Background: Diabetic wounds pose significant clinical challenges due to impaired healing processes, often resulting in chronic, nonhealing ulcers. Asiaticoside (AC), a natural triterpene derivative from , has demonstrated notable anti-inflammatory and wound-healing properties. However, the synergistic effects of nitric oxide (NO)-a recognized promoter of wound healing-combined with AC in treating diabetic wounds remain inadequately explored.

regulates gut microbiota and increases the effective metabolite luteolin to inhibit MAPK/STAT3 signaling pathway to alleviate allergic rhinitis.

The global prevalence of allergic rhinitis (AR) remains high, posing challenges due to its chronic nature and propensity for recurrence. Gut microbiota dysbiosis contributes to immune dysregulation, impacting AR pathogenesis. () has great potential in regulating immune function to alleviate AR symptoms.

The mediating roles of cognitive emotion regulation and resilience in the association between life events and sleep quality among medical students.

Background: Sleep quality in medical students can be influenced by numerous factors including life events, resilience, and cognitive emotion regulation strategies. Understanding the interplay between these factors is crucial for developing effective interventions to enhance medical students' mental health and well-being.

Objective: This study examined the association between life events and sleep quality and explored the mediating roles of resilience and cognitive emotion regulation in this relationship.

Efficacy and safety of nanoparticle albumin-bound paclitaxel plus cisplatin or nedaplatin plus tegafur/gimeracil/oteracil as induction chemotherapy regimen for hypopharyngeal cancer.

Background: Treatment of hypopharyngeal carcinoma involves surgery, radiotherapy, and chemotherapy. The combination of docetaxel, cisplatin, and 5-fluorouracil as a standard induction chemotherapy regimen allows enhanced laryngeal preservation after surgery. In this study, our objective was to retrospectively analyze the short-term efficacy and adverse events of nab-paclitaxel plus cisplatin or nedaplatin plus tegafur/gimeracil/oteracil as an induction chemotherapy regimen for hypopharyngeal cancer.

Design of an ultrasound appointment system based on a patient-centered real-time dynamic resource allocation strategy.

Introduction: The existing ultrasound appointment system faces multiple challenges, including a lack of diversity in its operation modes, sluggish efficiency, and limited flexibility. During emergency situations, such as disease outbreaks or severe disaster events, the demand for ultrasound examinations skyrockets, making it imperative to offer patients efficient and user-friendly ultrasound appointment services.

Methods: This study introduces the application of a patient-centered real-time dynamic resource allocation strategy in an ultrasound appointment system.

Comprehensive evaluation of the development of traditional Chinese medicine industry in Shaanxi province based on PMC index model.

Background: The high-quality development of the traditional Chinese medicine (TCM) industry is dependent on supportive policies and requires higher levels of coordination and integration. National and local government policies must coordinate the integrated development of the TCM industry under modern governance principles. However, the policy structure and its impact on the development of the TCM industry have not been thoroughly explored from the perspectives of policy design and empirical evidence.

Association between female cardiometabolic index and infertility: a population-based study.

Background: Visceral fat accumulation and dyslipidaemia are associated with infertility symptoms. The cardiometabolic index (CMI) is a comprehensive quantitative measure of central obesity and dyslipidaemia. However, the link between the female CMI and the couple infertility needs to be explored further.

Biochemical remission, diagnostic delays, and comorbidities of acromegaly in China: a large single-centre retrospective study.

Introduction: Long-term biochemical nonremission and long-delayed diagnosis can increase the incidence of comorbidities of acromegaly and seriously affect patients' quality of life. To identify predictors of biochemical remission and quantify the relationship between delayed diagnosis and comorbidities, we performed a retrospective study of a large, single-centre cohort.

Methods: This retrospective cohort included 1692 hospitalised patients with acromegaly seen in a single referral centre between 2012 and 2020.

Recurrence of Rosacea Induced by Compound Vitamin Tablets: A Case Report.

We present a case of rosacea recurrence in a 37-year-old woman associated with the intake of compound vitamin tablets during the preconception period, with a Naranjo score of 7. These tablets, commonly used for nutritional supplementation to prevent anemia, contain a variety of vitamins, minerals, and trace elements. Despite their widespread use, reports of such supplements causing rosacea recurrence are rare.

Bacteroides fragilis Toxin Suppresses METTL3-Mediated m6A Modification in Macrophage to Promote Inflammatory Bowel Disease.

Background And Aims: Bacteroides fragilis toxin (BFT), produced by enterotoxigenic B. fragilis (ETBF), is crucial for ETBF-induced colitis. This study aims to investigate the impact of BFT-host interactions on N6-methyladenosine (m6A) modification of host mRNA and its underlying mechanisms.

A supramolecular polypseudorotaxane material based on novel pillar[5]arene for ultrasensitive Fe reaction.

In this study, a novel linear supramolecular polypseudorotaxane was synthesized using a pillar[5]arene derivative (CP5) as the host and bis-bromohexyl pillar[5]arene (DP5) as the guest, facilitated by host-guest interactions. Subsequently, these components self-assembled to create an AIE-active material (CPDP-G) through C-H⋯π interactions involving the pillar[5]arene groups. Notably, the CPDP-G fluorescence material exhibits an exceptionally sensitive response to Fe, with a detection limit of 0.