Mechanism of YJKL Decoction in Treating of PCOS Infertility by Integrative Approach of Network Pharmacology and Experimental Verification.

Purpose: Currently, there is still no clear treatment for polycystic ovary syndrome (PCOS). YJKL has better therapeutic effects and lower toxic side effects for PCOS type infertility. This study aims to clarify the potential mechanism of YJKL Decoction in the treatment of PCOS based on network pharmacology and experiments verification.

Wood Ion Pumps Enabled by Light-Responsive MoS-Decorated Nanocellulosic Channels.

Light-driven active ion transport discovered in nanomaterials (e.g., graphene, metal-organic framework, and MXene) implicates crucial applications in membrane-based technology and energy conversion systems.

Self-Encapsulation of High-Entropy Alloy Nanoparticles inside Carbonized Wood for Highly Durable Electrocatalysis.

High-entropy alloy nanoparticles (HEAs) show great potential in emerging electrocatalysis due to their combination and optimization of multiple elements. However, synthesized HEAs often exhibit a weak interface with the conductive substrate, hindering their applications in long-term catalysis and energy conversion. Herein, a highly active and durable electrocatalyst composed of quinary HEAs (PtNiCoFeCu) encapsulated inside the activated carbonized wood (ACW) is reported.

HeadDiff: Exploring Rotation Uncertainty With Diffusion Models for Head Pose Estimation.

In this paper, we propose a probabilistic regression diffusion model for head pose estimation, dubbed HeadDiff, which typically addresses the rotation uncertainty, especially when faces are captured in wild conditions. Unlike conventional image-to-pose methods which cannot explicitly establish the rotational manifold of head poses, our HeadDiff aims to ensure the pose rotation via the diffusion process and in parallel, refine the mapping process iteratively. Specifically, we initially formulate the head pose estimation problem as a reverse diffusion process, defining a paradigm for progressive denoising on the manifold, which explores the uncertainty by decomposing the large gap into intermediate steps.

Phosphatidylserine decarboxylase downregulation in uric acid‑induced hepatic mitochondrial dysfunction and apoptosis.

The molecular mechanisms underlying uric acid (UA)-induced mitochondrial dysfunction and apoptosis have not yet been elucidated. Herein, we investigated underlying mechanisms of UA in the development of mitochondrial dysfunction and apoptosis. We analyzed blood samples of individuals with normal UA levels and patients with hyperuricemia.

Programmable, Changeable, Origami Cellulose Films for Magnetically Controllable Soft Robots.

Magnetic soft robots composed of stimuli-responsive materials are promising for biomedical engineering applications; however, typical responsive materials are fabricated with nondegradable polymeric substrates. In this study, we report a flexible, biodegradable, and magnetically sensitive cellulose film (M-film) that can be utilized for magnetically controllable soft robots (M-robots) with programmable locomotion, cargo delivery, and remote wireless operation functions. The M-film with good foldability, origami, and magnetic properties is synthesized by a simple paper-making process using cellulose nanofibers, additive sodium alginate, and BaFeO particles.

Magnetic Heating Amorphous NiFe Hydroxide Nanosheets Encapsulated Ni Nanoparticles@Wood Carbon to Boost Oxygen Evolution Reaction Activity.

The oxygen evolution reaction (OER) has significant effects on the water-splitting process and rechargeable metal-air batteries; however, the sluggish reaction kinetics caused by the four-electron transfer process for transition metal catalysts hinder large-scale commercialization in highly efficient electrochemical energy conversion devices. Herein, a magnetic heating-assisted enhancement design for low-cost carbonized wood with high OER activity is proposed, in which Ni nanoparticles are encapsulated in amorphous NiFe hydroxide nanosheets (a-NiFe@Ni-CW) via direct calcination and electroplating. The introduction of amorphous NiFe hydroxide nanosheets optimizes the electronic structure of a-NiFe@Ni-CW, accelerating electron transfer and reducing the energy barrier in the OER.

Phosphoethanolamine cytidylyltransferase ameliorates mitochondrial function and apoptosis in hepatocytes in T2DM in vitro.

Liver function indicators are often impaired in patients with type 2 diabetes mellitus (T2DM), who present higher concentrations of aspartate aminotransferase, alanine aminotransferase, and gamma-glutamyl transferase than individuals without diabetes. However, the mechanism of liver injury in patients with T2DM has not been clearly elucidated. In this study, we performed a lipidomics analysis on the liver of T2DM mice, and we found that phosphatidylethanolamine (PE) levels were low in T2DM, along with an increase in diglyceride, which may be due to a decrease in the levels of phosphoethanolamine cytidylyltransferase (Pcyt2), thus likely affecting the de novo synthesis of PE.

Palmitic Acid Inhibits the Growth and Metastasis of Gastric Cancer by Blocking the STAT3 Signaling Pathway.

Lipidomic analyses have suggested that palmitic acid (PA) is linked to gastric cancer. However, its effects and action mechanisms remain unclear. Therefore, we evaluated the effects of PA on cell proliferation, invasion, and apoptosis in human gastric cancer, as well as the role of p-STAT3 in mediating its effects.

Hyperuricemia induces liver injury by upregulating HIF-1α and inhibiting arginine biosynthesis pathway in mouse liver and human L02 hepatocytes.

The molecular mechanisms of uric acid (UA)-induced liver injury has not been clearly elucidated. In this study, we aimed to investigate the effect and action mechanisms of UA in liver injury. We analyzed the damaging effect of UA on mouse liver and L02 cells and subsequently performed metabolomics studies on L02 cells to identify abnormal metabolic pathways.

Magnetically Driven 3D Cellulose Film for Improved Energy Efficiency in Solar Evaporation.

The architecture of cellulose nanomaterials is definitized by random deposition and cannot change in response to shifting application requirements. Herein, we present a magnetic field-controlled cellulose film derived from wood that exhibits great magnetic properties and reliable tunability enabled by incorporated FeO nanoparticles and cellulose nanofibers (CNF) with a large length-diameter ratio. FeO nanoparticles are dispersed in suspensions of CNF so as to enhance the magnetic response.

Ultra-high rate capability of nanoporous carbon network@VO sub-micron brick composite as a novel cathode material for asymmetric supercapacitors.

A green biomass-derived nanoporous carbon network (NCN) has been prepared and integrated with V2O5 sub-micron bricks (SMBs). The large surface area and high pore volume of the NCN can not only provide abundant sites for electrochemical reactions but also stabilize the structure of the V2O5 SMBs. The NCN@V2O5 SMB composite, acting as a novel cathode material, delivers a high areal capacitance of 786 mF cm-2 at 0.

Multicentre laboratory validation of the nitrate reductase assay using liquid medium for the rapid detection of multidrug-resistant and extensively drug-resistant Mycobacterium tuberculosis.

To perform a multicentre study evaluating the performance of the nitrate reductase assay (NRA) using liquid medium for the detection of multidrug-resistant and extensively drug-resistant Mycobacterium tuberculosis and to establish the MICs and critical concentrations of rifampicin, isoniazid, ofloxacin, amikacin, kanamycin and capreomycin. The study was carried out in three phases. Phase I determined the MIC of each drug.

Evaluation of the microscopic observation drug susceptibility assay for the rapid detection of MDR-TB and XDR-TB in China: a prospective multicentre study.

Objectives: To perform a multicentre study evaluating the performance of the microscopic observation drug susceptibility (MODS) assay for the detection of MDR-TB and XDR-TB in high-burden resource-limited settings.

Methods: We performed a prospective diagnostic accuracy study of drug-resistant TB suspects from outpatient and inpatient settings in five laboratories in China. Sputum was tested by smear microscopy, liquid [mycobacterial growth indicator tube (MGIT)] culture and the MODS assay at each site.