Publications by authors named "Yaoxing Duan"

. Robotic systems can overcome some limitations of laparoscopic total mesorectal excision (L-TME), thus improving the quality of the surgery. So far, many studies have reported the technical feasibility and short-term oncological results of robotic total mesorectal excision (R-TME) in treating rectal cancer (RC); however, only a few evaluated the survival and long-term oncological outcomes.

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Purpose: To compare the clinical efficacy and safety between laparoscopic complete mesocolic excision (CME) and traditional radical operation for colon cancer in the treatment of stage III colon cancer.

Methods: A total of 196 patients with stage III colon cancer treated in out hospital from January 2014 to February 2016 were selected and divided into two groups using a random number table. One group (CME group, n=98) received laparoscopic CME, while another group (Traditional group, n=98) underwent traditional radical operation for colon cancer.

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Amount of studies in cells and animal models have proved vitamin D has multifarious antitumor effects. However, epidemiological studies showed inconsistent result on gastric cancer. The antitumor role is mainly mediated by the vitamin D receptor (VDR).

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Multiple primary malignant neoplasms (MPMN) are two or more malignancies in an individual without any relationship between the tumors. In recent years, increasing number of cases were reported. However, Synchronous double primary gastric and endometrial cancer are relatively rare to be reported.

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Article Synopsis
  • - The study investigates how S-adenosylmethionine (SAM) affects the growth of gastric cancer by altering the methylation of the VEGF-C gene promoter.
  • - Researchers used MTT analyses and a nude mouse model to show that SAM significantly increases the methylation of the VEGF-C promoter, leading to decreased protein levels of VEGF-C, which is linked to cancer growth.
  • - The findings suggest that SAM can reverse DNA hypomethylation of VEGF-C, effectively inhibiting gastric cancer growth both in lab experiments and in live subjects.
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Background: Recent studies have suggested that the metastasis-associated colon cancer1 (MACC1) gene can promote tumor proliferation, invasion and metastasis through an upregulation of c-Met expression. However, its role in gastric cancer is controversial. Our study investigated expression of MACC1 and c-Met in gastric cancer, as well as correlated this with clinicopathological parameters.

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Overexpression of vascular endothelial growth factor-C (VEGF-C) has been implicated as a critical molecular signal in tumor development by promoting intratumoral lymphangiogenesis. The aim of this study was to explore whether small hairpin RNA (shRNA) targeting VEGF-C could inhibit gastric cancer lymphangiogenesis and tumor growth. Plasmid-mediated expression of VEGF-C-shRNA was employed to silence VEGF-C gene expression in human SGC-7901 cell lines.

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