Publications by authors named "Yaoqiang Du"
Multi-omics technologies and molecular biomarkers in brain tumor-related epilepsy.
CNS Neurosci Ther
April 2024
Article Synopsis
- Brain tumors significantly contribute to intractable epilepsy, particularly brain tumor-related epilepsy (BTRE), which poses a heavy burden on patients and healthcare costs.
- Multi-omics technologies have advanced research into the complex factors influencing BTRE, including genetic and molecular biomarkers, providing insights into its pathophysiological mechanisms.
- Key findings highlight the role of specific genes like BRAF and IDH in the development of BTRE, as well as potential biomarkers for diagnosis and treatment, indicating the necessity for novel approaches in managing this condition.
Unraveling the role of CD24 in Hepatocellular carcinoma: Involvement of inactivated Hippo signaling and SOX4-mediated regulation.
Biochim Biophys Acta Mol Basis Dis
April 2024
Article Synopsis
- Hepatocellular carcinoma (HCC) is a common liver cancer, and the CD24 gene is linked to its progression but its regulatory mechanisms aren't fully understood.
- In this study, researchers created a primary HCC mouse model and discovered that CD24 levels increased due to the inactivation of the Hippo pathway, revealing a specific pathway (Hippo-YAP1-SOX4) that promotes CD24 upregulation in HCC cells.
- By reducing CD24 expression, they noted a significant decrease in HCC progression driven by YAP1, indicating that CD24 could be a potential target for treating a specific subclass of HCC linked to Hippo pathway inactivation.
Article Synopsis
- Infertility impacts 10-15% of men globally, with genetic factors causing issues in about one-third of cases, particularly linked to the protein PICK1 and its deficiency affecting Sertoli cell function.
- The study aims to use multi-omics analysis to explore the effects of PICK1 deficiency on Sertoli cells and find biomarkers that distinguish fertile males from those infertile due to this deficiency.
- Results reveal two mutations in PICK1 associated with infertility, decreased serum inhibin B, and impaired Sertoli cell function, alongside significant metabolic and gene expression changes in a PICK1-deficient mouse model, correlating with reduced testis volume and sperm production.
Article Synopsis
- Intrathyroid thymic carcinoma (ITTC) is a rare thyroid cancer thought to arise from ectopic thymus or embryonic remnants, with radical resection being the standard treatment and the role of postoperative radiation in early-stage cases still debated.* -
- A case report details a patient with early-stage ITTC who underwent total thyroidectomy and received postoperative radiation therapy, resulting in no signs of cancer recurrence after four years.* -
- The conclusion suggests considering routine adjuvant radiotherapy for patients with incompletely resected ITTC and those with tumor extension beyond the thyroid, while also providing a broad comparison of ITTC with other types of thyroid cancers.*
Article Synopsis
- Disulfidptosis is a new form of programmed cell death, and this study explores the role of disulfidptosis-related genes (DRGs) in predicting breast cancer outcomes.
- Using data from 1231 patients, researchers identified four specific DRG-related lncRNAs for creating a prognostic risk model, finding that lower risk scores were linked to longer patient survival.
- The study’s model effectively predicted overall survival and drug sensitivity in breast cancer patients, indicating its potential value in clinical decision-making and treatment management.
Article Synopsis
- Researchers have found that SARS-CoV-2 can use various receptors beyond ACE2 and TMPRSS2 to enter host cells, highlighting the need for efficient validation methods for potential receptors.
- The study introduced a DnaE intein-based cell-cell fusion system, which allows for quick simulation of the virus infecting host cells and confirmed that proteins like AXL and NRP1 play significant roles in this process.
- Findings indicate that mutations in the Delta variant's spike protein favor interaction with AXL, raising important considerations for developing therapies and treatments against SARS-CoV-2.
Article Synopsis
- PICK1 is essential for proper vesicle trafficking in sperm cells; its deficiency can disrupt acrosome formation and lead to male infertility.
- Researchers identified a unique variant in the PICK1 gene linked to a patient’s azoospermia and created a PICK1 knockout mouse model to study its effects.
- The findings revealed sperm abnormalities, decreased sperm motility, and mitochondrial dysfunction in the knockout mice, indicating that mutations in PICK1 can cause infertility issues in both mice and humans.
Transfusion support for a patient with alloanti-D and the RHD*DV.1 allele.
Clin Chim Acta
February 2023
Article Synopsis
- Safe blood transfusion is complicated by the Rh blood group's antigen variations and high autoantibody levels, which can affect patient outcomes.
- A male patient with serious liver disease and bleeding had an unexpected immunological response during his D+ red blood cell transfusion due to previously undetected autoantibodies; more advanced testing was needed.
- Genotyping and additional serological tests helped reveal the presence of specific antibodies, emphasizing that combining different methods can enhance blood transfusion safety and efficacy.
Characteristics of gastric cancer gut microbiome according to tumor stage and age segmentation.
Appl Microbiol Biotechnol
October 2022
Article Synopsis
- The study explores how the gut microbiome relates to gastric cancer (GC), focusing on differences between early gastric cancer (EGC) and advanced gastric cancer (AGC).
- Results show that surgery impacts gut microbiota more significantly in EGC patients compared to AGC patients, with specific bacteria differing between the two stages.
- Additionally, the findings indicate that the age of onset for gastric cancer affects the composition of gut microbiota, highlighting differences between early-onset and late-onset gastric cancer patients.
Article Synopsis
- - The study investigates the role of gut microbiota in gastric cancer patients, particularly examining how surgery, chemotherapy, and lymph node metastasis affect these microbiota using 16S rRNA sequencing of 157 fecal samples.
- - Results show that specific gut bacteria can distinguish between patients who have undergone surgery and those who haven't, while no significant differences were found related to chemotherapy or lymph node metastasis.
- - The abundance of certain gut microbiota is linked to key cancer markers (Ki67 and HER2), suggesting potential for these bacteria to serve as prognostic indicators in gastric cancer treatment.
Article Synopsis
- The study aims to discover molecular clusters linked to ferroptosis and create a related gene signature to help improve breast cancer treatment and prognosis.
- Methods involved using advanced statistical techniques to analyze the effectiveness of the ferroptosis-related gene signature in predicting patient outcomes and evaluating its relationship with immune responses and drug sensitivity.
- Results showed that the signature can distinguish high-risk from low-risk breast cancer patients in terms of relapse-free survival and may guide personalized treatment strategies based on individual immune microenvironments.
Article Synopsis
- The study aimed to enhance the accuracy of blood transfusion consent and streamline the verification process, as well as improve temperature control and reduce labor costs in blood transportation.
- An electronic signing process was developed that personalizes consent text, ensures filling accuracy, and communicates with the blood transfusion management system, while a centralized blood transport system with full-time nurses and temperature-controlled delivery was established.
- Results indicated a 100% consent accuracy with the electronic method, saved an average of 26 minutes in verification time, improved temperature control by 7.24 minutes per unit, and reduced transportation costs by $3.67 per unit, demonstrating significant improvements in transfusion management.
Article Synopsis
- The gut microbiota plays a significant role in colon inflammation and is linked to the early development of colorectal cancer (CRC), prompting the need for a new noninvasive screening method.
- A microbiome-based model, which discriminates between CRC and non-CRC cases using fecal samples, showed a high accuracy rate (AUC of 92.2%) and can potentially identify high-risk individuals.
- The study confirmed associations between CRC and specific microbial features, supporting the model’s utility as a reliable screening tool due to its low false-positive rate and stability.
Article Synopsis
- Cell membrane-camouflaged nanoparticles (NPs), which mimic cell membranes, show promise in enhancing drug delivery for various applications.
- The study developed platelet and tumor cell membrane-coated β-mangostin-loaded NPs (β-PCNPs) and tested their ability to target glioma cells in lab and animal models.
- Results showed that β-PCNPs significantly improved drug targeting and increased treatment effectiveness, leading to better outcomes in tumor growth inhibition and sustained drug circulation in the bloodstream compared to traditional nanoparticles.
Article Synopsis
- The emergence of novel coronavirus mutants is worsening the epidemic, prompting urgent studies on their pathogenicity and how mutations affect the binding of the virus to the ACE2 receptor.
- Researchers focused on specific non-RBM mutations (N354D, D364Y, and V367F) alongside a control (Q498A) to understand their impact on the RBD-ACE2 interaction through molecular dynamics simulations and experimental verification.
- Results indicated that non-RBM mutations alter the RBD's conformation and hydrogen bonding, with D364Y and V367F showing increased affinity for ACE2, while N354D weakened the binding due to a looser conformation and unexpected changes in binding free energy.
Article Synopsis
- The study analyzes the differences in gut microbiota between healthy individuals and gastric cancer patients, highlighting significant variations in fecal flora.
- Research indicates that the gut microbiota in gastric cancer patients is similar to that of esophageal cancer patients, while comparisons with small intestine cancer were limited due to its lower incidence.
- The review emphasizes the potential of gut microbiota as a tool for early diagnosis of gastric cancer and suggests directions for future research in this area.
Article Synopsis
- The WNASV initiative aimed to improve outpatient clinic services by enhancing the information system, ultimately boosting service quality and patient satisfaction.
- An Internet-based care delivery system was implemented to streamline processes, reduce waiting times, and analyze patient payment methods from May 2017 to September 2019.
- Results showed a significant decrease in waiting and consultation times, an increase in self-service and consultation payments, and a rise in patient satisfaction scores, indicating the success of the initiative.
Article Synopsis
- PICK1 is a protein associated with cancer progression, but its specific role in gastric cancer (GC) has not been well understood.
- Analysis of GC data revealed that PICK1 expression is significantly lower in gastric tumor tissues compared to normal tissues, suggesting its potential importance in the disease.
- Additionally, decreased PICK1 expression is linked to poorer survival rates in patients and is associated with the epithelial-mesenchymal transition (EMT) pathway, indicating it could serve as a key biomarker for GC.
Gut microbiome analysis as a predictive marker for the gastric cancer patients.
Appl Microbiol Biotechnol
January 2021
Article Synopsis
- Gut microbiota alterations are linked to gastric cancer development, with significant shifts in composition and diversity observed in cancer patients compared to healthy individuals.
- The study identified Lactobacillus and Megasphaera as predictive markers for gastric cancer, suggesting their potential role in diagnosis.
- Chemotherapy impacts the gut microbiome by reducing the abundance of certain bacteria, and gastritis exhibits some microbiome characteristics similar to those found in gastric cancer.
Article Synopsis
- C21 steroidal glycosides have been shown to be effective in treating various cancers, and this study focused on a synthesized C21 fraction's effects on gastric cancer cell lines.
- Significant growth inhibition, cell cycle arrest, and increased apoptosis were observed in gastric cancer cells treated with the C21 fraction, particularly when combined with the autophagy inhibitor chloroquine.
- The study highlights a novel mechanism for C21's anti-tumor activity, emphasizing its ability to trigger apoptosis by altering the balance of pro- and anti-apoptotic proteins and increasing reactive oxygen species production.
Article Synopsis
- An amendment to the paper has been published.
- The amendment can be accessed through a link located at the top of the paper.
- This update likely contains important changes or additional information.
Article Synopsis
- The study focuses on uncovering the genetic factors related to autism spectrum disorder (ASD) to improve understanding and diagnosis.
- Researchers analyzed coding de novo variants (DNVs) from over 4,500 ASD patients and 3,000 controls, finding a notable presence of extreme DNVs in ASD individuals, which correlated with lower IQ scores.
- The results support an oligogenic model for ASD, identifying 56 key genes and 23 new potential candidate genes linked to the disorder.
Article Synopsis
- Group B streptococcus (GBS) has emerged as a significant pathogen linked to neonatal infections, affecting critical organs such as the brain, lungs, and eyes.
- GBS is a leading cause of perinatal infection, contributing to high rates of neonatal illness and death in the United States.
- In China, while GBS is mainly associated with adult and perinatal infections, reports of neonatal GBS infections are infrequent, leading to debate about the actual incidence and clinical recognition of the disease compared to western countries.
Article Synopsis
- Recent whole-exome sequencing studies reveal the impact of de novo mutations (DNMs) on epileptic encephalopathies, particularly in West syndrome.
- Three loss-of-function DNMs were identified in the CSNK1E and STXBP1 genes, with one mutation leading to a premature stop codon in CSNK1E.
- The findings suggest a significant link between CSNK1E variants and epilepsy susceptibility, as well as connections to various neuropsychiatric disorders through a network of coexpressed genes, highlighting its role in midbrain development.
Article Synopsis
- This study identifies 63 high-confidence genes associated with intellectual disability (ID) by analyzing de novo mutations (DNMs) across multiple cohorts.
- Bioinformatic analysis reveals these ID genes are significantly involved in FMRP and CHD8 targets, display evolutionary constraints, and are mostly expressed in early to mid-fetal brain regions.
- Two biological modules related to ID risk were found, focusing on chromatin modification and synaptic function, indicating different underlying mechanisms for their effects on brain development.