Generation of a 25-line flattened optical frequency comb and its coherent beating properties.

A 25-line flattened optical frequency comb (OFC) is generated by cascading Mach-Zehnder modulators, and its coherent beating properties are investigated. The effect of bias voltages and the power of radio frequency signals on the flatness of the OFC, and the phase relationships between each comb line are theoretically deduced. In the experiment, a 25-line OFC with a flatness of less than 1 dB and an optical sideband suppression ratio of 12 dB is successfully demonstrated, and the agreement between simulation and experimental results supports the validity of the model for analysis of the flatness.

Tailoring a Hybrid Functional Layer for Mg Metal Anodes in Conventional Electrolytes with a Low Overpotential.

The development of high-voltage Mg metal batteries is hampered by the incompatibility between a Mg metal anode and conventional electrolyte, leading to a high overpotential for Mg plating/stripping processes. In this work, we tailored a hybrid functional layer consisting of Bi/MgCl/polytetrahydrofuran (PTHF) by an in situ THF polyreaction during the reaction of the Mg anode with BiCl solution. The introduction of PTHF inhibits the growth of Bi particles and fills the layer interstice with MgCl-containing PTHF, improving the structural integrity of the functional layer and insulation between the electrolyte and Mg anode.

Balancing the Risk-Benefit Ratio of Immune Checkpoint Inhibitor and Anti-VEGF Combination Therapy in Renal Cell Carcinoma: A Systematic Review and Meta-Analysis.

Background: Although immune checkpoint inhibitors (ICIs) combined with vascular endothelial growth factor receptor (VEGFR)-targeted therapy and sunitinib monotherapy have been widely applied to metastatic renal cell carcinoma (mRCC), effectiveness and safety data are still lacking. To optimize clinical decision-making, we conducted a systematic review and meta-analysis of published randomized clinical trials to characterize the efficacy and the risk of adverse events (AEs) in patients treated with ICIs plus anti-VEGF therapy.

Materials And Methods: We used PubMed, EMBASE, and the Cochrane Library to retrieve randomized controlled trials (RCTs) published before March 27, 2021.

Anti-yeast activity of a food-grade dilution-stable microemulsion.

The anti-yeast activities of a food-grade dilution-stable microemulsion against Candida albicans and Saccharomyces cerevisiae have been studied. The weight ratio of the formulated microemulsion is glycerol monolaurate (GML)/propionic acid/Tween 80/sodium benzoate (SB)/water = 3:9:14:14:24. Results of anti-yeast activity on solid medium by agar diffusion method showed that the anti-yeast activity of the microemulsion at 4.