The Study of Overexpression of Peroxiredoxin-2 Reduces MPP-Induced Toxicity in the Cell Model of Parkinson's Disease.

Parkinson's disease (PD) is a chronic neurodegenerative disorder characterized by dopaminergic neuron loss, which is related to excessive reactive oxygen species (ROS) accumulation. Endogenous peroxiredoxin-2 (Prdx-2) has potent anti-oxidative and anti-apoptotic effects. Proteomics studies revealed plasma levels of Prdx-2 were significantly lower in PD patients than in healthy individuals.

Clinical impact of Fn-induced high expression of KIR2DL1 in CD8 T lymphocytes in oesophageal squamous cell carcinoma.

Background: To analyze the correlation between the inducing effect of (Fn) on the surface expression of the inhibitory receptor KIR2DL1 on CD8 T cells in oesophageal squamous cell carcinoma (ESCC) and the clinicopathological features and survival prognosis and to explore its clinical significance.

Methods: The inducing effect of Fn on CD8 T cell surface inhibitory receptor KIR2DL1 expression was analyzed in a coculture system of human CD8 T cells and ESCC cells infected with Fn. Fn infection and the expression of KIR2DL1 on CD8 T cells were detected by RNAscope and immunohistochemistry in ESCC tissues, and the correlations between the inducing effect of Fn on KIR2DL1 expression on CD8 T cells and clinicopathological features were analyzed.