Publications by authors named "Yaokang Chen"
Article Synopsis
- - The study explores the connection between gut microbiota (GM) and depression, highlighting how inflammation might link them and the potential for personalized treatment through early screening of GM.
- - A hypothesis was tested using Mendelian Randomization analysis to examine the relationship between GM, cytokines, and depression, suggesting that immune imbalance can signal early risk for depression.
- - Results identified 15 GM taxa and 4 cytokines related to depression risk, with some acting as protective factors while others were linked to increased risk, setting the stage for a more predictive and preventive approach to treating depression.
Article Synopsis
- - The study investigated how exercise affects depressive-like behaviors in mice on a high-fat diet (HFD), with results showing that exercise improved mood and reversed negative gene expression changes in the hippocampus.
- - Researchers found that the protein Wnt5a is a key mediator for how exercise alleviates depression symptoms linked to a high-fat diet by activating neuronal autophagy in the hippocampus.
- - The findings suggest that enhancing synaptic plasticity via the Wnt5a/CamkII signaling pathway is crucial for the positive effects of exercise on depression related to high-fat diets, with an inhibitor that blocked Wnt5a negating these benefits.
The communication mechanism of the gut-lung axis has received increasing attention in recent years, particularly in acute respiratory infectious diseases such as influenza. The peripheral immune system serves as a crucial bridge between the gut and the lungs, two organs that are not in close proximity to each other. However, the specific communication mechanism involving gut microbiota, immune cells, and their anti-influenza effects in the lung remains to be further elucidated.
View Article and Find Full Text PDFBackground: Dietary intervention is the preferred approach for the prevention and clinical management of gout. Nevertheless, the existing evidence regarding the influence of specific foods on gout is insufficient.
Methods: We used two-sample Mendelian randomization for genetic prediction to analyze the relationship between the intake of more than a dozen daily food items, such as pork, beef, cheese, and poultry, and dietary macronutrient intake (fat, protein, carbohydrates, and sugar) and the risk of developing gout and elevating the serum uric acid level.
Influenza A, the most common subtype, induces 3 to 5 million severe infections and 250,000 to 500,000 deaths each year. Vaccination is traditionally considered to be the best way to prevent influenza A. Yet because the Influenza A virus (IAV) is highly susceptible to antigenic drift and Antigenic shift, and because of the lag in vaccine production, this poses a significant challenge to vaccine effectiveness.
View Article and Find Full Text PDFArticle Synopsis
- The study conducts a bibliometric evaluation of research on mucosal immunity and commensal microbiota over the past 20 years, analyzing 1423 articles from various journals and institutions globally.
- It highlights the important role of commensal microbiota in regulating the immune response and maintaining interaction with the host.
- Key research trends identified include the impact of specific microbiota metabolites on mucosal immunity and the interplay between COVID-19, mucosal immunity, and microbiota.
Testicular and Spermatic Cord Metastases from Gastric Adenocarcinoma: An Unusual Case.
Cancer Manag Res
February 2021
The metastasis of gastric cancer to the testis or spermatic cord is very rare; however, simultaneous testicular and spermatic cord metastases are even rarer. Here, we report an unusual case of a 54-year-old male patient who had undergone radical gastrectomy for gastric adenocarcinoma more than two years before. He complained of palpable painful masses in the right scrotum and inguinal area occurring for more than half a year.
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