Publications by authors named "Yaojin Zhu"
Article Synopsis
- * The study involved creating three types of PEGylated acacetin to improve its solubility and anti-inflammatory properties, with PEG-Acacetin showing the most promise by significantly boosting plasma levels and demonstrating increased anti-inflammatory effects.
- * In tests on mice, PEG-Acacetin effectively reduced bone loss caused by both lipopolysaccharide and ovariectomy, outperforming naked acacetin and suggesting it could be a strong candidate for osteoporosis treatment.
Proteolysis-targeting chimeras (PROTACs) have emerged as a promising strategy for targeted protein degradation and drug discovery. To overcome the inherent limitations of conventional PROTACs, an innovative drugtamer-PROTAC conjugation approach is developed to enhance tumor targeting and antitumor potency. Specifically, a smart prodrug is designed by conjugating "drugtamer" to a nicotinamide phosphoribosyltransferase (NAMPT) PROTAC using a tumor microenvironment responsible linker.
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