and Expression is Regulated by C in CRISPR/Cas9-Edited HepG2 Cells.

Functional (G>A, rs2242480) in cytochrome P450 () regulates the drug-metabolizing enzyme expression. The objective of this study was to investigate whether regulates both basal and rifampicin (RIF)-induced expression and enzyme activity of and in gene-edited human HepG2 cells. GG and AA genotype HepG2 cells were established using the clustered regularly interspaced short palindromic repeats/CRISPR-associated protein 9 (CRISPR/Cas9) single nucleotide polymorphism technology and homology-directed repair in the GA HepG2 cell line.