PUTransGCN: identification of piRNA-disease associations based on attention encoding graph convolutional network and positive unlabelled learning.

Piwi-interacting RNAs (piRNAs) play a crucial role in various biological processes and are implicated in disease. Consequently, there is an escalating demand for computational tools to predict piRNA-disease interactions. Although there have been computational methods proposed for the detection of piRNA-disease associations, the problem of imbalanced and sparse dataset has brought great challenges to capture the complex relationships between piRNAs and diseases.

The role of circular RNA in preeclampsia: From pathophysiological mechanism to clinical application.

Preeclampsia (PE) is a common pregnancy-induced hypertension disorder that poses a significant threat to the health of pregnant women and fetuses, and has become a leading cause of maternal, fetal, and neonatal mortality. Currently, the therapy strategy for PE is mainly prevention management and symptomatic treatment, and only delivery can completely terminate PE. Therefore, a deeper understanding of the pathogenesis of PE is needed to make treatment and prevention more effective and targeted.

Ultrathin MXene nanosheet-based TiO/CdS heterostructure as a photoelectrochemical sensor for detection of CEA in human serum samples.

To develop highly accurate and ultrasensitive strategies is of great importance for the clinical measurement, in particular, the detection of cancer biomarkers. Herein, we synthesized an ultrasensitive TiO/MXene/CdS QDs (TiO/MX/CdS) heterostructure as a photoelectrochemical immunosensor, which favors energy levels matching and fast electron transfer from CdS to TiO in the help of ultrathin MXene nanosheet. Dramatic photocurrent quenching can be observed upon incubation of the TiO/MX/CdS electrode by Cu solution from 96-well microplate, which caused by the formation of CuS and subsequent CuS (x = 1, 2), reducing the absorption of light and boosting the electron-hole recombination upon irradiation.