Construction of electrochemical immunosensors based on Au@MXene and Au@CuS nanocomposites for sensitive detection of carcinoembryonic antigen.

Cancer is currently one of the major causes of human mortality and has received widespread attention. In this paper, Au@CuS composite nanomaterial as a sandwich immunosensor tag for carcinoembryonic antigen (CEA) detection strategy was studied. Herein, Au@CuS composite nanomaterials were obtained by Au nanoparticles modified with CuS, which were combined with secondary antibody (Ab) to construct an immunosensor that interacted with HO to produce a current response.

Effectiveness and safety of B cell-targeting biologics in the treatment of lupus nephritis: a systematic review and network meta‑analysis.

Objectives: To evaluate the effectiveness and safety of different B cell-targeting biological agents combining with standard of care in patients with lupus nephritis (LN).

Methods: Comprehensive literature searches were conducted using PubMed, Embase, Web of Science, and Central in the Cochran Library, spanning from inception to May 20th, 2024. Randomized control trials (RCTs) comparing rituximab (RTX), belimumab, ocrelizumab, obinutuzumab, and anifrolumab in LN were selected.

Single-atom nanozymes: Emerging talent for sensitive detection of heavy metals.

In recent years, the increasingly severe pollution of heavy metals has posed a significant threat to the environment and human safety. Heavy metal ions are highly non-biodegradable, with a tendency to accumulate through biomagnification. Consequently, accurate detection of heavy metal ions is of paramount importance.

Comparative efficacy and safety of SGLT2is and ns-MRAs in patients with diabetic kidney disease: a systematic review and network meta-analysis.

Objectives: To evaluate the efficacy and safety of non-steroid mineralocorticoid receptor antagonists (ns-MRAs) and sodium-glucose cotransporter 2 inhibitors (SGLT2is) in patients with diabetic kidney disease (DKD).

Methods: Systematic literature searches were performed using PubMed, Embase and Web of Science encompassing inception until January 20, 2024. Randomized control trials (RCTs) comparing ns-MRAs and SGLT2is in DKD were selected.

Multiple signal-enhanced electrochemiluminescence aptamer sensors based on carboxylated ruthenium (II) complexes for acetamiprid detection.

Background: Rapid and sensitive detection for acetamiprid, a kind of widely used neonicotinoid insecticide, is very meaningful for the development of modern agriculture and the protection of human health. Highly stable electrochemiluminescence (ECL) materials are one of the key factors in ECL sensing technology. ECL materials prepared by porous materials (e.

Ferroptosis in renal fibrosis: a mini-review.

Ferroptosis is a novel form of programmed cell death that is iron-dependent and distinct from autophagy, apoptosis, and necroptosis. It is primarily characterised by a decrease in glutathione peroxidase 4 (GPX4) activity, or by the accumulation of lipid peroxidation and reactive oxygen species (ROS). Renal fibrosis is a common pathological change in the progression of various primary and secondary renal diseases to end-stage renal disease and poses a serious threat to human health with high morbidity and mortality.

Magnetic photoelectrochemical sensor array utilizing addressing sensing strategy for simultaneous detection of amyloid-β 42 and microtubule-associated protein tau.

The accurate diagnosis of diseases can be improved by detecting multiple biomarkers simultaneously. This study presents the development of a magnetic photoelectrochemical (PEC) immunosensor array for the simultaneous detection of amyloid-β 42 (Aβ) and microtubule-associated protein (Tau), which are markers for neurodegenerative disorders. A metal-organic framework (MOF) derivative, FeO@FeS magnetic composites with exceptional photoelectric and ferromagnetic properties was synthesized while preserving the original structure and advantages.

Mental health and lower urinary tract symptoms: Results from the NHANES and Mendelian randomization study.

Background: The clinical observations suggest a correlation between lower urinary tract symptoms (LUTSs) and mental health problems. Nonetheless, establishing a direct causal relationship between them remains challenging.

Methods: We initially conducted a cross-sectional study using 2005-2018 the National Health and Nutrition Examination Survey (NHANES) data.

A novel nanoprobe for visually investigating the controversial role of miRNA-34a as an oncogene or tumor suppressor in cancer cells.

MiRNA-targeted therapy has become a hot topic in current cancer research. The key to this treatment strategy is to clarify the specific role of miRNA in cancer. However, the roles of some miRNAs acting as oncogenic or tumor suppressors are still controversial, which are influenced by different tumor types, even in the same cancer type.

The Electrochemical Actuation Performances of Nanoporous Ternary AlCoCu Alloy with a Unique Nanosheet Structure.

Compared to traditional actuators (such as piezoelectric ceramics), metal actuators possess the advantages of a low energy consumption, large strain amplitude, and high strain energy density. However, most of the existing metal actuators with an excellent comprehensive performance are composed of precious metals, which are limited by high costs and have almost no possibility for large-scale production in the future. This study focuses on non-precious metal materials and exploits a one-step chemical dealloying method to prepare bulk nanoporous (NP) CoCuAl actuators (NP-CCA) from AlCoCu alloy.

Ultrasensitive Photoelectrochemical Immunoassay Strategy Based on BiS/AgS for the Detection of the Inflammation Marker Procalcitonin.

As an inflammatory marker, procalcitonin (PCT) is more representative than other traditional inflammatory markers. In this work, a highly efficient photoelectrochemical (PEC) immunosensor was constructed based on the photoactive material BiS/AgS to realize the sensitive detection of PCT. BiS was prepared by a hydrothermal method, and AgS quantum dots were deposited on the ITO/BiS surface via in situ reduction.

Comparing efficacy and safety of first-line treatment of metastatic renal cell carcinoma: A Bayesian network meta-regression analysis.

Background: This Bayesian network meta-regression analysis provides a head-to-head comparison of first-line therapeutic immune checkpoint inhibitors (ICI) and tyrosine kinase inhibitors (TKI) combinations for metastatic renal cell carcinoma (mRCC) using median follow-up time as covariate.

Methods: We searched Six databases for a comprehensive analysis of randomised clinical trials (RCTs). Comparing progression free survival (PFS) and overall survival (OS) of different interventions at the same time node by Bayesian network meta-analysis.

Split-Type Photoelectrochemical/Visual Sensing Platform Based on SnO/MgInS/ZnCdS Composites and Au@FeO Nanoparticles for Ultrasensitive Detection of Neuron Specific Enolase.

Herein, a novel dual mode detection system of split-type photoelectrochemical (PEC) and visual immunoassay was developed to detect neuron specific enolase (NSE), which achieved simultaneous and reliable NSE detection due to the completely different signal readouts and transduction mechanism. Specifically, specific reactions of antigens and antibodies were performed in 96-microwell plates. Gold nanoparticle (Au NP)-loaded FeO (Au@FeO) NPs were used as secondary antibody markers and signal regulators, which could produce a blue-colored solution in the presence of 3,3',5,5'-tetramethylbenzidine (TMB) and HO because of its peroxidase-like activity.

Enhancing the mechanical strength and toughness of epoxy resins with linear POSS nano-modifiers.

Glass transition temperature ( ) always deteriorates while improving the strength of epoxy resins which inherently suffer from brittleness. Herein, novel linear polyhedral oligomeric silsesquioxane (POSS)-epoxy nano-modifiers are synthesized with variable contents of POSS. The thermomechanical properties and chemical structure study of the POSS-epoxy indicates significant differences of the rigid POSS content in the linear nano-modifiers.

Signal-enhanced electrochemiluminescence strategy using iron-based metal-organic frameworks modified with carboxylated Ru(II) complexes for neuron-specific enolase detection.

The preparation of highly efficient electrochemiluminescence (ECL) illuminants is an effective method to improve the sensitivity and repeatability of ECL immunoassay. In this study, we prepared an ECL immunoassay for efficient and sensitive detection of neuron-specific enolase (NSE) by linking carboxylated Ru(bpy) to an iron-based metal-organic framework (NH-MIL-88 (Fe)) via an amide bond as an ECL signal probe. NH-MIL-88 (Fe) possesses a large number of amino groups that can catalyze the co-reactant SO, which generates abundant reaction intermediates SO around Ru(dcbpy), reduces the loss of material transport and energy transfer between SO and Ru(dcbpy), and significantly enhances the ECL signal.

A novel molecularly imprinted electrochemiluminescence sensor based on cobalt nitride nanoarray electrode for the sensitive detection of bisphenol S.

A substitute for bisphenol A (BPA), bisphenol S (BPS) has endocrine disruptive and toxic effects and could pose potential risk on human health and the environment. Herein, we fabricated a sensitive molecularly imprinted electrochemiluminescence (MIECL) sensor for the determination of BPS. CoN nanoarray with outstanding electrical conductivity was prepared and it directly served as the sensor platform.

Research Progress of Graphene and Its Derivatives towards Exhaled Breath Analysis.

The metabolic process of the human body produces a large number of gaseous biomarkers. The tracking and monitoring of certain diseases can be achieved through the detection of these markers. Due to the superior specific surface area, large functional groups, good optical transparency, conductivity and interlayer spacing, graphene, and its derivatives are widely used in gas sensing.

Ultrasensitive Photochemical Immunosensor Based on Flowerlike SnO/BiOI/AgS Composites for Detection of Procalcitonin.

Based on the necessity and urgency of detecting infectious disease marker procalcitonin (PCT), a novel unlabeled photoelectrochemical (PEC) immunosensor was prepared for the rapid and sensitive detection of PCT. Firstly, SnO porous nanoflowers with good photocatalytic performance were prepared by combining hydrothermal synthesis and calcining. BiOI nanoflowers were synthesized by facile ultrasonic mixed reaction.

Sandwich-type photoelectrochemical immunosensor for procalcitonin detection based on Mn doped CdS sensitized BiWO and signal amplification of NaYF:Yb, Tm upconversion nanomaterial.

In this paper, we constructed a sandwich-type photoelectrochemical (PEC) immunosensor for the quantitative detection of procalcitonin (PCT) based on the sensitization of Mn doped CdS (CdS:Mn) nanocomposites to BiWO and the signal amplification effect of an upconversion material NaYF:Yb,Tm. BiWO was synthesized with a three-dimensional flowered structure. CdS:Mn reduced the recombination of photogenerated carriers, and significantly improved photocurrent response.

Adsorption Performance of Amino Functionalized Magnetic Molecular Sieve Adsorbent for Effective Removal of Lead Ion from Aqueous Solution.

Lead ion (Pb) has high toxicity and brings great harm to human body. It is very important to find an effective method to address lead ion pollution. In this work, amino functionalized CoFeO/SBA-15 nanocomposite (NH-CoFeO/SBA-15) was prepared for the effective removal of Pb from aqueous solution.

Electrochemical aptasensor based on gold modified thiol graphene as sensing platform and gold-palladium modified zirconium metal-organic frameworks nanozyme as signal enhancer for ultrasensitive detection of mercury ions.

Gold modified thiol graphene (Au@HS-rGO) was prepared and applied as sensing platform for constructing the electrochemical aptasensor. While gold-palladium modified zirconium metal-organic frameworks (AuPd@UiO-67) nanozyme was employed as signal enhancer for detecting mercury ions (Hg) sensitively. Herein, gold nanoparticles (Au NPs) were modified on HS-rGO to form the thin Au@HS-rGO layer.