Multidrug resistant among Acinetobacter baumannii infection is associated with a high mortality rate and limits the therapeutic options. The aim of this study was to assess the safety and efficacy of colistin monotherapy vs. other single antibiotic therapy AND colistin-based combination therapy (with other antibiotics) vs.
View Article and Find Full Text PDFThe aim of this study was to assess the relationship between urinary Smad1 and glomerular hyperfiltration (GHF) in type 2 diabetes mellitus (T2DM), and to explore the factors related to the urinary Smad1 in T2DM. The reference value of the estimated glomerular filtration rate (eGFR) was determined in 248 healthy individuals. 30 patients with GHF, 58 patients with norm-GFR T2DM, and 24 healthy patients who served as controls were recruited.
View Article and Find Full Text PDFThe purpose of this study was to investigate the prevalence of tubular damage in short-term (less than five years) type 2 diabetes mellitus (T2DM) patients and to explore the correlation between tubular markers and their relationship with renal indices at different stages of diabetic nephropathy. A group of 101 short-term T2DM patients and 28 control subjects were recruited. Tubular markers, such as neutrophil gelatinase-associated lipocalin (NGAL), N-acetyl-β-D: -glucosaminidase (NAG), and kidney injury molecule 1 (KIM-1), as well as urinary albumin excretion were measured in voided urine.
View Article and Find Full Text PDFObjective: To investigate the effects of Rubus suavissimus S. Lee extract (RSE) on mice, and its influence on release of histamine from rat peritoneal mast cells induced by compound 48/80 in vitro.
Methods: To establish murine delayed-type-hypersensitive model induced by 2,4-dinitrofluotobenzene (DNFB) and sheep red blood cell (SRBC); murine type I allergic reaction induced by PCA, and then to observe the anti-allergic effect of RSE.